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Simultaneous administration of Haemophilus influenzae type b capsular polysaccharide-diphtheria toxoid conjugate vaccine with routine diphtheria-tetanus-pertussis and inactivated poliovirus vaccinations of childhood.
Pediatr Infect Dis J. 1988 Jul; 7(7):480-4.PI

Abstract

A Haemophilus influenzae type b capsular polysaccharide-diphtheria toxoid conjugate vaccine (PRP-D) is capable of protecting infants against invasive H. influenzae diseases. Therefore it is very likely that it will be incorporated in routine vaccination schedules during the next few years. In order to test the suitability of simultaneous administration of PRP-D and other vaccines we administered it to 25 infants mixed with diphtheria-tetanus-pertussis vaccine at 3, 4 and 6 months and simultaneously, but in a separate syringe, with inactivated polio vaccine at 12 months. A comparison group of equal size received only diphtheria-tetanus-pertussis and inactivated poliovirus vaccines. The concentration of postvaccination antibodies to diphtheria toxoid was 0.411 IU/ml in the group that received PRP-D vs. 0.352 IU/ml in the comparison group, to tetanus toxoid 3.666 vs. 3.668 IU/ml and the neutralization titer to poliovirus type 1 was 370 vs. 320 units in the comparison group, to type 2 titer values were 230 vs. 270 units and to type 3, respectively, 210 vs. 290 units. Thus the seroresponse to antigens in routine vaccines was not affected by the presence of PRP-D in the vaccination schedule, and PRP-D can safely and effectively be included in the vaccination schedule of infancy.

Authors+Show Affiliations

Eskola J
National Public Health Institute, Helsinki, Finland.
Käyhty H
No affiliation info available
Gordon LK
No affiliation info available
Hovi T
No affiliation info available
Stenvik M
No affiliation info available
Rönnberg PR
No affiliation info available
Kela E
No affiliation info available
Peltola H
No affiliation info available

MeSH

Bacterial VaccinesDiphtheria ToxoidDiphtheria-Tetanus-Pertussis VaccineDrug CombinationsFinlandHaemophilus VaccinesHumansImmunization ScheduleInfantPertussis VaccinePoliovirus Vaccine, InactivatedTetanus ToxoidVaccines, Attenuated

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3261414

Citation

Eskola, J, et al. "Simultaneous Administration of Haemophilus Influenzae Type B Capsular Polysaccharide-diphtheria Toxoid Conjugate Vaccine With Routine Diphtheria-tetanus-pertussis and Inactivated Poliovirus Vaccinations of Childhood." The Pediatric Infectious Disease Journal, vol. 7, no. 7, 1988, pp. 480-4.
Eskola J, Käyhty H, Gordon LK, et al. Simultaneous administration of Haemophilus influenzae type b capsular polysaccharide-diphtheria toxoid conjugate vaccine with routine diphtheria-tetanus-pertussis and inactivated poliovirus vaccinations of childhood. Pediatr Infect Dis J. 1988;7(7):480-4.
Eskola, J., Käyhty, H., Gordon, L. K., Hovi, T., Stenvik, M., Rönnberg, P. R., Kela, E., & Peltola, H. (1988). Simultaneous administration of Haemophilus influenzae type b capsular polysaccharide-diphtheria toxoid conjugate vaccine with routine diphtheria-tetanus-pertussis and inactivated poliovirus vaccinations of childhood. The Pediatric Infectious Disease Journal, 7(7), 480-4.
Eskola J, et al. Simultaneous Administration of Haemophilus Influenzae Type B Capsular Polysaccharide-diphtheria Toxoid Conjugate Vaccine With Routine Diphtheria-tetanus-pertussis and Inactivated Poliovirus Vaccinations of Childhood. Pediatr Infect Dis J. 1988;7(7):480-4. PubMed PMID: 3261414.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Simultaneous administration of Haemophilus influenzae type b capsular polysaccharide-diphtheria toxoid conjugate vaccine with routine diphtheria-tetanus-pertussis and inactivated poliovirus vaccinations of childhood. AU - Eskola,J, AU - Käyhty,H, AU - Gordon,L K, AU - Hovi,T, AU - Stenvik,M, AU - Rönnberg,P R, AU - Kela,E, AU - Peltola,H, PY - 1988/7/1/pubmed PY - 1988/7/1/medline PY - 1988/7/1/entrez SP - 480 EP - 4 JF - The Pediatric infectious disease journal JO - Pediatr Infect Dis J VL - 7 IS - 7 N2 - A Haemophilus influenzae type b capsular polysaccharide-diphtheria toxoid conjugate vaccine (PRP-D) is capable of protecting infants against invasive H. influenzae diseases. Therefore it is very likely that it will be incorporated in routine vaccination schedules during the next few years. In order to test the suitability of simultaneous administration of PRP-D and other vaccines we administered it to 25 infants mixed with diphtheria-tetanus-pertussis vaccine at 3, 4 and 6 months and simultaneously, but in a separate syringe, with inactivated polio vaccine at 12 months. A comparison group of equal size received only diphtheria-tetanus-pertussis and inactivated poliovirus vaccines. The concentration of postvaccination antibodies to diphtheria toxoid was 0.411 IU/ml in the group that received PRP-D vs. 0.352 IU/ml in the comparison group, to tetanus toxoid 3.666 vs. 3.668 IU/ml and the neutralization titer to poliovirus type 1 was 370 vs. 320 units in the comparison group, to type 2 titer values were 230 vs. 270 units and to type 3, respectively, 210 vs. 290 units. Thus the seroresponse to antigens in routine vaccines was not affected by the presence of PRP-D in the vaccination schedule, and PRP-D can safely and effectively be included in the vaccination schedule of infancy. SN - 0891-3668 UR - https://www.unboundmedicine.com/medline/citation/3261414/Simultaneous_administration_of_Haemophilus_influenzae_type_b_capsular_polysaccharide_diphtheria_toxoid_conjugate_vaccine_with_routine_diphtheria_tetanus_pertussis_and_inactivated_poliovirus_vaccinations_of_childhood_ DB - PRIME DP - Unbound Medicine ER -
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