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Association between Common Vaginal Infections and Cervical Non-HPV16/18 Infection in HPV-Vaccinated Women.
J Infect Dis. 2020 Jul 02 [Online ahead of print]JI

Abstract

BACKGROUND

How vaginal infections like bacterial vaginosis (BV), Candida spp., and Trichomonas vaginalis (TV) affect persistence of human papillomavirus (HPV) infection is not well established. Our study aimed to evaluate the association between common vaginal infections and cervical non-HPV16/18 infection, as risk factors associated with persistence of non-vaccine HPV types will become increasingly relevant in the setting of HPV vaccination.

METHODS

We performed an analysis in 2,039 AS04-HPV16/18-vaccinated women enrolled in a phase II/III trial in China, who were HPV DNA-negative at Month 0 and 6 and had at least one subsequent follow-up visit. Vaginal infections were detected in liquid-based cytology according to the diagnostic criteria of The Bethesda System. Associations between vaginal infections and incident and 6-month persistent non-HPV16/18 infections in the cervix were evaluated using generalized estimating equations, adjusting for the age at initial vaccination, as well as HPV types in the persistence analysis.

RESULTS

Study visits with any vaginal infection had a statistically significant increased risk of incident non-HPV16/18 infection compared to those without vaginal infections(OR:1.44,95%CI:1.09-1.92). However, vaginal infections were not associated with 6-month persistent non-HPV16/18 infection (OR:1.02,95%CI:0.62-1.69).

CONCLUSIONS

Our study suggests that common vaginal infections are not associated with persistence of non-HPV16/18 infection among HPV16/18-vaccinated women.

Authors+Show Affiliations

Department of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.Department of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.Department of Gynecologic Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.Department of Obstetrics and Gynecology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.Department of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32614401

Citation

Hu, Shang-Ying, et al. "Association Between Common Vaginal Infections and Cervical Non-HPV16/18 Infection in HPV-Vaccinated Women." The Journal of Infectious Diseases, 2020.
Hu SY, Tsang SH, Chen F, et al. Association between Common Vaginal Infections and Cervical Non-HPV16/18 Infection in HPV-Vaccinated Women. J Infect Dis. 2020.
Hu, S. Y., Tsang, S. H., Chen, F., Pan, Q. J., Zhang, W. H., Hong, Y., Sampson, J. N., Hildesheim, A., Zhao, F. H., & Kreimer, A. R. (2020). Association between Common Vaginal Infections and Cervical Non-HPV16/18 Infection in HPV-Vaccinated Women. The Journal of Infectious Diseases. https://doi.org/10.1093/infdis/jiaa384
Hu SY, et al. Association Between Common Vaginal Infections and Cervical Non-HPV16/18 Infection in HPV-Vaccinated Women. J Infect Dis. 2020 Jul 2; PubMed PMID: 32614401.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between Common Vaginal Infections and Cervical Non-HPV16/18 Infection in HPV-Vaccinated Women. AU - Hu,Shang-Ying, AU - Tsang,Sabrina H, AU - Chen,Feng, AU - Pan,Qin-Jing, AU - Zhang,Wen-Hua, AU - Hong,Ying, AU - Sampson,Joshua N, AU - Hildesheim,Allan, AU - Zhao,Fang-Hui, AU - Kreimer,Aimée R, Y1 - 2020/07/02/ PY - 2020/04/01/received PY - 2020/7/3/entrez KW - Candida spp KW - Trichomonas vaginalis KW - Bacterial vaginosis KW - Human papillomavirus KW - vaccination JF - The Journal of infectious diseases JO - J. Infect. Dis. N2 - BACKGROUND: How vaginal infections like bacterial vaginosis (BV), Candida spp., and Trichomonas vaginalis (TV) affect persistence of human papillomavirus (HPV) infection is not well established. Our study aimed to evaluate the association between common vaginal infections and cervical non-HPV16/18 infection, as risk factors associated with persistence of non-vaccine HPV types will become increasingly relevant in the setting of HPV vaccination. METHODS: We performed an analysis in 2,039 AS04-HPV16/18-vaccinated women enrolled in a phase II/III trial in China, who were HPV DNA-negative at Month 0 and 6 and had at least one subsequent follow-up visit. Vaginal infections were detected in liquid-based cytology according to the diagnostic criteria of The Bethesda System. Associations between vaginal infections and incident and 6-month persistent non-HPV16/18 infections in the cervix were evaluated using generalized estimating equations, adjusting for the age at initial vaccination, as well as HPV types in the persistence analysis. RESULTS: Study visits with any vaginal infection had a statistically significant increased risk of incident non-HPV16/18 infection compared to those without vaginal infections(OR:1.44,95%CI:1.09-1.92). However, vaginal infections were not associated with 6-month persistent non-HPV16/18 infection (OR:1.02,95%CI:0.62-1.69). CONCLUSIONS: Our study suggests that common vaginal infections are not associated with persistence of non-HPV16/18 infection among HPV16/18-vaccinated women. SN - 1537-6613 UR - https://www.unboundmedicine.com/medline/citation/32614401/Association_between_Common_Vaginal_Infections_and_Cervical_Non-HPV16/18_Infection_in_HPV-Vaccinated_Women L2 - https://academic.oup.com/jid/article-lookup/doi/10.1093/infdis/jiaa384 DB - PRIME DP - Unbound Medicine ER -
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