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Fungal recognition by mammalian fibrinogen-related proteins.
Scand J Immunol. 2020 Jul 02 [Online ahead of print]SJ

Abstract

Fungi are ubiquitous eukaryotic microorganisms present in virtually all environmental habitats. Although rarely pathogenic to the healthy population, many fungal species are capable of causing human disease in immunocompromised individuals. Thus, fungal infections remain a significant cause of morbidity and mortality, with rising prevalence accompanying the worldwide increase in immunosuppression-based therapies. Therefore, better understanding of the mutual interactions between the protective host mechanisms and the invading fungi remains of critical importance. The innate immune system constitutes the first line of defense against exogenous insults. The innate antifungal immunity is mediated through recognition of specific pathogen-associated molecular patterns (PAMPs) by a broad panel of host pattern recognition receptors (PRRs), responsible for mounting adequate protective responses. In this review, we describe fungal PAMPs as well as a selection of PRRs able to recognize them. We focus on the members of the fibrinogen-related domain (FReD) protein family that have been shown to recognize fungi-derived molecules: ficolins, fibrinogen C domain containing 1 (FIBCD1) and tenascin-C. We describe their structure, their binding targets and their established as well as putative biological functions related to fungal recognition and immunity.

Authors+Show Affiliations

Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32614476

Citation

Pilecki, Bartosz, and Jesper Bonnet Moeller. "Fungal Recognition By Mammalian Fibrinogen-related Proteins." Scandinavian Journal of Immunology, 2020, pp. e12925.
Pilecki B, Moeller JB. Fungal recognition by mammalian fibrinogen-related proteins. Scand J Immunol. 2020.
Pilecki, B., & Moeller, J. B. (2020). Fungal recognition by mammalian fibrinogen-related proteins. Scandinavian Journal of Immunology, e12925. https://doi.org/10.1111/sji.12925
Pilecki B, Moeller JB. Fungal Recognition By Mammalian Fibrinogen-related Proteins. Scand J Immunol. 2020 Jul 2;e12925. PubMed PMID: 32614476.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fungal recognition by mammalian fibrinogen-related proteins. AU - Pilecki,Bartosz, AU - Moeller,Jesper Bonnet, Y1 - 2020/07/02/ PY - 2020/7/3/entrez SP - e12925 EP - e12925 JF - Scandinavian journal of immunology JO - Scand. J. Immunol. N2 - Fungi are ubiquitous eukaryotic microorganisms present in virtually all environmental habitats. Although rarely pathogenic to the healthy population, many fungal species are capable of causing human disease in immunocompromised individuals. Thus, fungal infections remain a significant cause of morbidity and mortality, with rising prevalence accompanying the worldwide increase in immunosuppression-based therapies. Therefore, better understanding of the mutual interactions between the protective host mechanisms and the invading fungi remains of critical importance. The innate immune system constitutes the first line of defense against exogenous insults. The innate antifungal immunity is mediated through recognition of specific pathogen-associated molecular patterns (PAMPs) by a broad panel of host pattern recognition receptors (PRRs), responsible for mounting adequate protective responses. In this review, we describe fungal PAMPs as well as a selection of PRRs able to recognize them. We focus on the members of the fibrinogen-related domain (FReD) protein family that have been shown to recognize fungi-derived molecules: ficolins, fibrinogen C domain containing 1 (FIBCD1) and tenascin-C. We describe their structure, their binding targets and their established as well as putative biological functions related to fungal recognition and immunity. SN - 1365-3083 UR - https://www.unboundmedicine.com/medline/citation/32614476/Fungal_recognition_by_mammalian_fibrinogen-related_proteins L2 - https://doi.org/10.1111/sji.12925 DB - PRIME DP - Unbound Medicine ER -
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