Tags

Type your tag names separated by a space and hit enter

Risk Factors, Molecular Epidemiology, and Outcomes of Carbapenem-Resistant Klebsiella pneumoniae Infection for Hospital-Acquired Pneumonia: A Matched Case-Control Study in Eastern China During 2015-2017.
Microb Drug Resist. 2020 Jul 02 [Online ahead of print]MD

Abstract

This study was conducted to acknowledge microbiological and clinical characteristics of hospital-acquired pneumonia (HAP) caused by carbapenem-resistant Klebsiella pneumoniae (CRKP). A retrospective, 1:1 matched (age, gender, specimen source, and ward) case-control study was conducted during 2015-2017 in a tertiary teaching hospital in Anhui, China. Multivariate logistic regression analysis demonstrated that prior central venous catheter use, sputum suction, continuous renal replacement therapy, and exposure to fluroquinolones were independent risk factors for the morbidity of CRKP infection for HAP. Treatment failure for infection was an independent risk factor for crude in-hospital mortality, while the use of fluroquinolones may improve the effective treatment for infection (p = 0.040). Among 74 CRKP strains, 85.1% of them were positive for the production of KPC-2, and one of them was detected for co-harboring blaKPC-2 and blaIMP-38-like. Separately, sequence type (ST) 11 (81.1%) was the predominant ST in this study, and ST11 CRKP isolates were related with higher detection rate of blaKPC-2 and lower resistance rate to trimethoprim/sulfamethoxazole when compared with non-ST11 ones. Moreover, resistance to carbapenem was associated with higher mortality (35.1%) and hospitalization costs for HAP patients with K. pneumoniae infection. Invasive procedures may increase the morbidity of CRKP infection for HAP. Prior exposure to fluroquinolones is associated with the development of resistance, but as a targeted treatment it may be effective.

Authors+Show Affiliations

Department of Clinical Laboratory and The First Affiliated Hospital of Anhui Medical University, Hefei, China.Department of Infection Disease, The First Affiliated Hospital of Anhui Medical University, Hefei, China.Department of Clinical Laboratory and The First Affiliated Hospital of Anhui Medical University, Hefei, China.Department of Infection Disease, The First Affiliated Hospital of Anhui Medical University, Hefei, China.Department of Clinical Laboratory and The First Affiliated Hospital of Anhui Medical University, Hefei, China.Department of Clinical Laboratory and The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32614722

Citation

Zuo, Yan, et al. "Risk Factors, Molecular Epidemiology, and Outcomes of Carbapenem-Resistant Klebsiella Pneumoniae Infection for Hospital-Acquired Pneumonia: a Matched Case-Control Study in Eastern China During 2015-2017." Microbial Drug Resistance (Larchmont, N.Y.), 2020.
Zuo Y, Zhao D, Song G, et al. Risk Factors, Molecular Epidemiology, and Outcomes of Carbapenem-Resistant Klebsiella pneumoniae Infection for Hospital-Acquired Pneumonia: A Matched Case-Control Study in Eastern China During 2015-2017. Microb Drug Resist. 2020.
Zuo, Y., Zhao, D., Song, G., Li, J., Xu, Y., & Wang, Z. (2020). Risk Factors, Molecular Epidemiology, and Outcomes of Carbapenem-Resistant Klebsiella pneumoniae Infection for Hospital-Acquired Pneumonia: A Matched Case-Control Study in Eastern China During 2015-2017. Microbial Drug Resistance (Larchmont, N.Y.). https://doi.org/10.1089/mdr.2020.0162
Zuo Y, et al. Risk Factors, Molecular Epidemiology, and Outcomes of Carbapenem-Resistant Klebsiella Pneumoniae Infection for Hospital-Acquired Pneumonia: a Matched Case-Control Study in Eastern China During 2015-2017. Microb Drug Resist. 2020 Jul 2; PubMed PMID: 32614722.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk Factors, Molecular Epidemiology, and Outcomes of Carbapenem-Resistant Klebsiella pneumoniae Infection for Hospital-Acquired Pneumonia: A Matched Case-Control Study in Eastern China During 2015-2017. AU - Zuo,Yan, AU - Zhao,Dongmei, AU - Song,Guobin, AU - Li,Jiabin, AU - Xu,Yuanhong, AU - Wang,Zhongxin, Y1 - 2020/07/02/ PY - 2020/7/3/entrez PY - 2020/7/3/pubmed PY - 2020/7/3/medline KW - carbapenem-resistant Klebsiella pneumoniae KW - hospital-acquired pneumonia KW - molecular epidemiology KW - outcomes KW - risk factors JF - Microbial drug resistance (Larchmont, N.Y.) JO - Microb. Drug Resist. N2 - This study was conducted to acknowledge microbiological and clinical characteristics of hospital-acquired pneumonia (HAP) caused by carbapenem-resistant Klebsiella pneumoniae (CRKP). A retrospective, 1:1 matched (age, gender, specimen source, and ward) case-control study was conducted during 2015-2017 in a tertiary teaching hospital in Anhui, China. Multivariate logistic regression analysis demonstrated that prior central venous catheter use, sputum suction, continuous renal replacement therapy, and exposure to fluroquinolones were independent risk factors for the morbidity of CRKP infection for HAP. Treatment failure for infection was an independent risk factor for crude in-hospital mortality, while the use of fluroquinolones may improve the effective treatment for infection (p = 0.040). Among 74 CRKP strains, 85.1% of them were positive for the production of KPC-2, and one of them was detected for co-harboring blaKPC-2 and blaIMP-38-like. Separately, sequence type (ST) 11 (81.1%) was the predominant ST in this study, and ST11 CRKP isolates were related with higher detection rate of blaKPC-2 and lower resistance rate to trimethoprim/sulfamethoxazole when compared with non-ST11 ones. Moreover, resistance to carbapenem was associated with higher mortality (35.1%) and hospitalization costs for HAP patients with K. pneumoniae infection. Invasive procedures may increase the morbidity of CRKP infection for HAP. Prior exposure to fluroquinolones is associated with the development of resistance, but as a targeted treatment it may be effective. SN - 1931-8448 UR - https://www.unboundmedicine.com/medline/citation/32614722/Risk_Factors,_Molecular_Epidemiology,_and_Outcomes_of_Carbapenem-Resistant_Klebsiella_pneumoniae_Infection_for_Hospital-Acquired_Pneumonia:_A_Matched_Case-Control_Study_in_Eastern_China_During_2015-2017 L2 - https://www.liebertpub.com/doi/10.1089/mdr.2020.0162?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.