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Operational Strategies for Clinical Trials in Africa.
JCO Glob Oncol. 2020 Jun; 6:973-982.JG

Abstract

PURPOSE

In a dramatic reversal of longstanding trends, cancer now kills more Africans than malaria. Despite Africa's growing cancer burden, individuals of African descent, notably those residing in Africa, remain drastically under-represented in cancer clinical trials. Two recent summits-the 1st All Africa Clinical Trial Summit and the Operational Strategy for Clinical Trials in Nigeria Summit-convened experts from governments, the private sector, universities, and professional societies to define the barriers to Africa's participation in multicenter clinical studies and the strategies to eliminate those impedances.

METHODS

The discussions held during the two clinical trial summits were condensed into a set of 10 recommendations covering five broad categories (funding, regulation, capacity building, Africa-centric approach, and patient engagement). In this article, four programs are presented as examples of how the summits' recommendations can be put into practice to improve Africa's ability to attract clinical trials, in particular, cancer clinical trials.

RESULTS

These example programs all leveraged a multilateral, Africa-driven approach to building Africa's clinical trial capacity, increasing visibility of Africa's current clinical trial capabilities and priorities, improving regulatory infrastructure and enforcement on the continent, and optimizing patient and clinician engagement strategies.

CONCLUSION

The four programs are anticipated to catalyze the involvement of more African health care sites in cancer clinical trials, enroll a greater number of African patients with cancer in those trials, and, ultimately, reverse Africa's growing cancer incidence and mortality rates. Each program acts as a blueprint for organizations-whether government, academic, or industry-seeking to address the summits' recommendations and increase Africa's contributions to and active participation in clinical research.

Authors+Show Affiliations

BIO Ventures for Global Health, Seattle, WA.Department of Radiology, College of Medicine, University of Nigeria, Nsukka, Nigeria. University of Nigeria Centre for Clinical Trials, University of Nigeria Teaching Hospital, Enugu, Ituku Ozalla, Nigeria.National Centre for Radiotherapy and Nuclear Medicine, Korle Bu Teaching Hospital, Accra, Ghana.BIO Ventures for Global Health, Seattle, WA.University of Florida, Orlando, FL. Prostate Cancer Transatlantic Consortium, Orlando, FL.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32614727

Citation

Graef, Katy M., et al. "Operational Strategies for Clinical Trials in Africa." JCO Global Oncology, vol. 6, 2020, pp. 973-982.
Graef KM, Okoye I, Ohene Oti NO, et al. Operational Strategies for Clinical Trials in Africa. JCO Glob Oncol. 2020;6:973-982.
Graef, K. M., Okoye, I., Ohene Oti, N. O., Dent, J., & Odedina, F. T. (2020). Operational Strategies for Clinical Trials in Africa. JCO Global Oncology, 6, 973-982. https://doi.org/10.1200/JGO.19.00204
Graef KM, et al. Operational Strategies for Clinical Trials in Africa. JCO Glob Oncol. 2020;6:973-982. PubMed PMID: 32614727.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Operational Strategies for Clinical Trials in Africa. AU - Graef,Katy M, AU - Okoye,Ifeoma, AU - Ohene Oti,Naomi O, AU - Dent,Jennifer, AU - Odedina,Folakemi T, PY - 2020/7/3/entrez PY - 2020/7/3/pubmed PY - 2020/7/3/medline SP - 973 EP - 982 JF - JCO global oncology JO - JCO Glob Oncol VL - 6 N2 - PURPOSE: In a dramatic reversal of longstanding trends, cancer now kills more Africans than malaria. Despite Africa's growing cancer burden, individuals of African descent, notably those residing in Africa, remain drastically under-represented in cancer clinical trials. Two recent summits-the 1st All Africa Clinical Trial Summit and the Operational Strategy for Clinical Trials in Nigeria Summit-convened experts from governments, the private sector, universities, and professional societies to define the barriers to Africa's participation in multicenter clinical studies and the strategies to eliminate those impedances. METHODS: The discussions held during the two clinical trial summits were condensed into a set of 10 recommendations covering five broad categories (funding, regulation, capacity building, Africa-centric approach, and patient engagement). In this article, four programs are presented as examples of how the summits' recommendations can be put into practice to improve Africa's ability to attract clinical trials, in particular, cancer clinical trials. RESULTS: These example programs all leveraged a multilateral, Africa-driven approach to building Africa's clinical trial capacity, increasing visibility of Africa's current clinical trial capabilities and priorities, improving regulatory infrastructure and enforcement on the continent, and optimizing patient and clinician engagement strategies. CONCLUSION: The four programs are anticipated to catalyze the involvement of more African health care sites in cancer clinical trials, enroll a greater number of African patients with cancer in those trials, and, ultimately, reverse Africa's growing cancer incidence and mortality rates. Each program acts as a blueprint for organizations-whether government, academic, or industry-seeking to address the summits' recommendations and increase Africa's contributions to and active participation in clinical research. SN - 2687-8941 UR - https://www.unboundmedicine.com/medline/citation/32614727/Operational_Strategies_for_Clinical_Trials_in_Africa L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/32614727/ DB - PRIME DP - Unbound Medicine ER -
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