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The Relationship between Inter-muscular Fat and Physical Performance Is Moderated by Muscle Area in Older Adults.
J Gerontol A Biol Sci Med Sci. 2020 Jul 02 [Online ahead of print]JG

Abstract

BACKGROUND

Age-related deposition of fat in skeletal muscle is associated with functional limitations. Skeletal muscle fat may be present in people with preserved muscle mass or accompanied by muscle wasting. However, it is not clear if the association between muscle fat deposition and physical performance is moderated by muscle mass.

OBJECTIVE

To determine whether the association between mid-thigh inter-muscular fat and physical performance is moderated by muscle area.

METHODS

We performed a cross-sectional analysis of the Health ABC data collected in 2002-03 (n=1897, women:52.2%). Mid-thigh muscle cross-sectional area (by CT) and physical performance measures were compared across quartiles of inter-muscular fat absolute area. Moderation analysis was performed to determine the conditional effect of inter-muscular fat on physical performance as a function of muscle area. Conditional effects were evaluated at three levels of muscle area (mean and plus/minus 1 standard deviation (SD); 213.2±53.2 cm2).

RESULTS

Simple slope analysis showed that the negative association between inter-muscular fat area (cm2) and leg strength (N.m) was of greater magnitude [beta coefficient (b), 95% confidence interval (CI)=-0.288 (-0.427,-0.148)] in participants with greater muscle area (i.e., 1-SD above-the-mean) compared to those with lower muscle area [i.e., at mean (b=-0.12 (-0.248,0.008)) or 1-SD below-the-mean (b=0.048 (-0.122,0.217))]. Similarly, the negative association of inter-muscular fat with 400-m walk speed (meters/second) and chair stand (second) was greater in those with higher muscle areas (P<0.001) compared to those with lower muscle areas.

CONCLUSIONS

The association between higher inter-muscular fat area and impaired physical function in aging is moderated by muscle area.

Authors+Show Affiliations

Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA. Center for Aging and Population Health, University of Pittsburgh.Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA. Center for Aging and Population Health, University of Pittsburgh.Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA. Center for Aging and Population Health, University of Pittsburgh.Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA. Center for Aging and Population Health, University of Pittsburgh.Translational Research Institute for Metabolism and Diabetes, Orlando, FL. Sanford Burnham Presby Medical Discovery Institute, La Jolla, CA.Sticht Center for Healthy Aging and Alzheimer's Prevention, Wake Forest School of Medicine, Winston-Salem, NC.Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA. Center for Aging and Population Health, University of Pittsburgh.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32614950

Citation

Farsijani, Samaneh, et al. "The Relationship Between Inter-muscular Fat and Physical Performance Is Moderated By Muscle Area in Older Adults." The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 2020.
Farsijani S, Santanasto AJ, Miljkovic I, et al. The Relationship between Inter-muscular Fat and Physical Performance Is Moderated by Muscle Area in Older Adults. J Gerontol A Biol Sci Med Sci. 2020.
Farsijani, S., Santanasto, A. J., Miljkovic, I., Boudreau, R. M., Goodpaster, B. H., Kritchevsky, S. B., & Newman, A. B. (2020). The Relationship between Inter-muscular Fat and Physical Performance Is Moderated by Muscle Area in Older Adults. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. https://doi.org/10.1093/gerona/glaa161
Farsijani S, et al. The Relationship Between Inter-muscular Fat and Physical Performance Is Moderated By Muscle Area in Older Adults. J Gerontol A Biol Sci Med Sci. 2020 Jul 2; PubMed PMID: 32614950.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Relationship between Inter-muscular Fat and Physical Performance Is Moderated by Muscle Area in Older Adults. AU - Farsijani,Samaneh, AU - Santanasto,Adam J, AU - Miljkovic,Iva, AU - Boudreau,Robert M, AU - Goodpaster,Bret H, AU - Kritchevsky,Stephen B, AU - Newman,Anne B, Y1 - 2020/07/02/ PY - 2019/12/02/received PY - 2020/7/3/entrez PY - 2020/7/3/pubmed PY - 2020/7/3/medline KW - Myosteatosis KW - aging KW - muscle size and function KW - sarcopenia JF - The journals of gerontology. Series A, Biological sciences and medical sciences JO - J. Gerontol. A Biol. Sci. Med. Sci. N2 - BACKGROUND: Age-related deposition of fat in skeletal muscle is associated with functional limitations. Skeletal muscle fat may be present in people with preserved muscle mass or accompanied by muscle wasting. However, it is not clear if the association between muscle fat deposition and physical performance is moderated by muscle mass. OBJECTIVE: To determine whether the association between mid-thigh inter-muscular fat and physical performance is moderated by muscle area. METHODS: We performed a cross-sectional analysis of the Health ABC data collected in 2002-03 (n=1897, women:52.2%). Mid-thigh muscle cross-sectional area (by CT) and physical performance measures were compared across quartiles of inter-muscular fat absolute area. Moderation analysis was performed to determine the conditional effect of inter-muscular fat on physical performance as a function of muscle area. Conditional effects were evaluated at three levels of muscle area (mean and plus/minus 1 standard deviation (SD); 213.2±53.2 cm2). RESULTS: Simple slope analysis showed that the negative association between inter-muscular fat area (cm2) and leg strength (N.m) was of greater magnitude [beta coefficient (b), 95% confidence interval (CI)=-0.288 (-0.427,-0.148)] in participants with greater muscle area (i.e., 1-SD above-the-mean) compared to those with lower muscle area [i.e., at mean (b=-0.12 (-0.248,0.008)) or 1-SD below-the-mean (b=0.048 (-0.122,0.217))]. Similarly, the negative association of inter-muscular fat with 400-m walk speed (meters/second) and chair stand (second) was greater in those with higher muscle areas (P<0.001) compared to those with lower muscle areas. CONCLUSIONS: The association between higher inter-muscular fat area and impaired physical function in aging is moderated by muscle area. SN - 1758-535X UR - https://www.unboundmedicine.com/medline/citation/32614950/The_Relationship_between_Inter-muscular_Fat_and_Physical_Performance_Is_Moderated_by_Muscle_Area_in_Older_Adults L2 - https://academic.oup.com/biomedgerontology/article-lookup/doi/10.1093/gerona/glaa161 DB - PRIME DP - Unbound Medicine ER -
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