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Effect of plateletpheresis on total platelet count and mean platelet volume: A meta-analysis.
J Evid Based Med. 2020 Aug; 13(3):206-214.JE

Abstract

OBJECTIVE

Currently, there are discrepancies in the reports on the extent of the reduction in platelet count after platelet donation by apheresis, and its impact on mean platelet volume (MPV). This study was conducted to meta-analyze the effect of plateletpheresis on platelet count and on mean platelet volume, based on studies published between 1980 and 2018.

METHODS

Medline-Pubmed, Scielo, ScienceDirect, and Scopus databases were searched from inception to December 31 2019. The PRISMA guidelines, reproducibility, and evaluation of the methodological quality were guaranteed. Heterogeneity was evaluated with DerSimonian-Laird's, publication bias with a Begg's test. Sensitivity analysis and cumulative meta-analysis were also conducted, as well as a forest plot.

RESULTS

Twenty-five studies with 3769 donors were systematized to analyze platelet count, and seven studies with 1176 donors to observe MPV. Most studies were published in India and the United States. There was a postprocedure reduction in both variables. The reduction in platelet count was 14.3 × 103 /μL (95% CI 11.4 to 17.1 × 103 ⁄μL). The reduction in MPV was 1.43 fL (95% CI 0.3 to 2.5 fL). The analysis of subgroups showed that, in the case of platelet count, the reduction is not statistically significant two weeks after donation.

CONCLUSION

Platelet donation by apheresis reduces platelet count and MPV in donors, which is detrimental to the purposes of the procedure; although the decrease is not clinically significant for the donor or the recipient. This demonstrates the need for subsequent studies to evaluate variables, such as donation frequency and donation intervals, should be considered to evaluate if the reported decrease is easily compensated, without adverse consequences for donors, or if modifications in donor selection criteria are required.

Authors+Show Affiliations

Health and Sustainability Research Group, School of Microbiology, University of Antioquia, Medellin, Colombia.Bacteriologist and Clinical Laboratory, General Hospital of Medellín Luz Castro de Gutiérrez, University of Antioquia, Medellin, Colombia.Health and Sustainability Research Group, School of Microbiology, University of Antioquia, Medellin, Colombia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32615026

Citation

Gil-Betancur, Alejandro, et al. "Effect of Plateletpheresis On Total Platelet Count and Mean Platelet Volume: a Meta-analysis." Journal of Evidence-based Medicine, vol. 13, no. 3, 2020, pp. 206-214.
Gil-Betancur A, Mantilla-Gutierrez CY, Cardona-Arias JA. Effect of plateletpheresis on total platelet count and mean platelet volume: A meta-analysis. J Evid Based Med. 2020;13(3):206-214.
Gil-Betancur, A., Mantilla-Gutierrez, C. Y., & Cardona-Arias, J. A. (2020). Effect of plateletpheresis on total platelet count and mean platelet volume: A meta-analysis. Journal of Evidence-based Medicine, 13(3), 206-214. https://doi.org/10.1111/jebm.12403
Gil-Betancur A, Mantilla-Gutierrez CY, Cardona-Arias JA. Effect of Plateletpheresis On Total Platelet Count and Mean Platelet Volume: a Meta-analysis. J Evid Based Med. 2020;13(3):206-214. PubMed PMID: 32615026.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of plateletpheresis on total platelet count and mean platelet volume: A meta-analysis. AU - Gil-Betancur,Alejandro, AU - Mantilla-Gutierrez,Carmen Yulieth, AU - Cardona-Arias,Jaiberth Antonio, Y1 - 2020/07/02/ PY - 2019/05/13/received PY - 2020/01/01/accepted PY - 2020/7/3/pubmed PY - 2020/7/3/medline PY - 2020/7/3/entrez KW - mean platelet volume KW - meta-analysis KW - platelet count KW - plateletpheresis KW - systematic review SP - 206 EP - 214 JF - Journal of evidence-based medicine JO - J Evid Based Med VL - 13 IS - 3 N2 - OBJECTIVE: Currently, there are discrepancies in the reports on the extent of the reduction in platelet count after platelet donation by apheresis, and its impact on mean platelet volume (MPV). This study was conducted to meta-analyze the effect of plateletpheresis on platelet count and on mean platelet volume, based on studies published between 1980 and 2018. METHODS: Medline-Pubmed, Scielo, ScienceDirect, and Scopus databases were searched from inception to December 31 2019. The PRISMA guidelines, reproducibility, and evaluation of the methodological quality were guaranteed. Heterogeneity was evaluated with DerSimonian-Laird's, publication bias with a Begg's test. Sensitivity analysis and cumulative meta-analysis were also conducted, as well as a forest plot. RESULTS: Twenty-five studies with 3769 donors were systematized to analyze platelet count, and seven studies with 1176 donors to observe MPV. Most studies were published in India and the United States. There was a postprocedure reduction in both variables. The reduction in platelet count was 14.3 × 103 /μL (95% CI 11.4 to 17.1 × 103 ⁄μL). The reduction in MPV was 1.43 fL (95% CI 0.3 to 2.5 fL). The analysis of subgroups showed that, in the case of platelet count, the reduction is not statistically significant two weeks after donation. CONCLUSION: Platelet donation by apheresis reduces platelet count and MPV in donors, which is detrimental to the purposes of the procedure; although the decrease is not clinically significant for the donor or the recipient. This demonstrates the need for subsequent studies to evaluate variables, such as donation frequency and donation intervals, should be considered to evaluate if the reported decrease is easily compensated, without adverse consequences for donors, or if modifications in donor selection criteria are required. SN - 1756-5391 UR - https://www.unboundmedicine.com/medline/citation/32615026/Effect_of_plateletpheresis_on_total_platelet_count_and_mean_platelet_volume:_A_meta-analysis L2 - https://doi.org/10.1111/jebm.12403 DB - PRIME DP - Unbound Medicine ER -
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