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Gastrulation in Drosophila melanogaster: Genetic control, cellular basis and biomechanics.
Mech Dev. 2020 Jun 29 [Online ahead of print]MD

Abstract

Gastrulation is generally understood as the morphogenetic processes that result in the spatial organization of the blastomere into the three germ layers, ectoderm, mesoderm and endoderm. This review summarizes our current knowledge of the morphogenetic mechanisms in Drosophila gastrulation. In addition to the events that drive mesoderm invagination and germband elongation, we pay particular attention to other, less well-known mechanisms including midgut invagination, cephalic furrow formation, dorsal fold formation, and mesoderm layer formation. This review covers topics ranging from the identification and functional characterization of developmental and morphogenetic control genes to the analysis of the physical properties of cells and tissues and the control of cell and tissue mechanics of the morphogenetic movements in the gastrula.

Authors+Show Affiliations

Institute for Biology, Dept. Developmental Genetics, University of Kassel, Germany.Institute for Biology, Dept. Developmental Genetics, University of Kassel, Germany.Institute for Biology, Dept. Developmental Genetics, University of Kassel, Germany. Electronic address: h.a.muller@uni-kassel.de.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32615151

Citation

Gheisari, Elham, et al. "Gastrulation in Drosophila Melanogaster: Genetic Control, Cellular Basis and Biomechanics." Mechanisms of Development, 2020, p. 103629.
Gheisari E, Aakhte M, Müller HJ. Gastrulation in Drosophila melanogaster: Genetic control, cellular basis and biomechanics. Mech Dev. 2020.
Gheisari, E., Aakhte, M., & Müller, H. J. (2020). Gastrulation in Drosophila melanogaster: Genetic control, cellular basis and biomechanics. Mechanisms of Development, 103629. https://doi.org/10.1016/j.mod.2020.103629
Gheisari E, Aakhte M, Müller HJ. Gastrulation in Drosophila Melanogaster: Genetic Control, Cellular Basis and Biomechanics. Mech Dev. 2020 Jun 29;103629. PubMed PMID: 32615151.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastrulation in Drosophila melanogaster: Genetic control, cellular basis and biomechanics. AU - Gheisari,Elham, AU - Aakhte,Mostafa, AU - Müller,H-Arno J, Y1 - 2020/06/29/ PY - 2020/01/29/received PY - 2020/06/08/revised PY - 2020/06/24/accepted PY - 2020/7/3/entrez PY - 2020/7/3/pubmed PY - 2020/7/3/medline KW - Drosophila KW - Gastrulation KW - Germ band extension KW - Morphogenetic movements KW - Ventral furrow SP - 103629 EP - 103629 JF - Mechanisms of development JO - Mech. Dev. N2 - Gastrulation is generally understood as the morphogenetic processes that result in the spatial organization of the blastomere into the three germ layers, ectoderm, mesoderm and endoderm. This review summarizes our current knowledge of the morphogenetic mechanisms in Drosophila gastrulation. In addition to the events that drive mesoderm invagination and germband elongation, we pay particular attention to other, less well-known mechanisms including midgut invagination, cephalic furrow formation, dorsal fold formation, and mesoderm layer formation. This review covers topics ranging from the identification and functional characterization of developmental and morphogenetic control genes to the analysis of the physical properties of cells and tissues and the control of cell and tissue mechanics of the morphogenetic movements in the gastrula. SN - 1872-6356 UR - https://www.unboundmedicine.com/medline/citation/32615151/Gastrulation_in_Drosophila_melanogaster:_Genetic_control,_cellular_basis_and_biomechanics L2 - https://linkinghub.elsevier.com/retrieve/pii/S0925-4773(20)30034-4 DB - PRIME DP - Unbound Medicine ER -
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