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The effect of baclofen on objective and subjective sleep measures in a model of transient insomnia.
Sleep Med. 2020 Apr 04; 72:130-134.SM

Abstract

STUDY OBJECTIVES

Insomnia is a common medical complaint. Current pharmacologic treatments have modest efficacy and numerous side effects. Baclofen is a gamma-aminobutyric acid (GABA)b receptor agonist used to treat spasticity in various medical conditions. Several studies noted that baclofen, when used to treat sleep related disorders, resulted in improvement in sleep parameters. Measures of insomnia, however, were not assessed in those studies. To date, baclofen has not been assessed for efficacy in the treatment of insomnia.

METHODS

We randomized 20 healthy subjects to baclofen or placebo in a cross over design. All subjects underwent two polysomnograms (PSG) assessing sleep parameters. Baclofen or placebo was given 90 min prior to lights out in random order for each subject. Lights out occurred two hours earlier than the subject's median habitual bedtime.

RESULTS

Baclofen resulted in significantly less objective wake after sleep onset and stage 1 sleep, and significantly increased total sleep time (TST), sleep efficiency, and stage 3/4 sleep. There was no effect on sleep onset latency (SOL). Self-report variables indicated significantly less subjective awakenings from sleep and increased subjective sleep quality. There was no effect on subjective TST or subjective SOL.

CONCLUSIONS

This study showed that baclofen was superior to placebo with regard to several objective and subjective measures used to assess sleep quality. These data support the notion that baclofen shows promise as an effective hypnotic drug.

Authors+Show Affiliations

University of Oklahoma Health Sciences Center, Section of Pulmonary Critical Care & Sleep Medicine, Oklahoma City, OK, USA. Electronic address: Samih-Raad@ouhsc.edu.Lynn Health Science Institute, Oklahoma City, OK, USA. Electronic address: Meredith-Wilkerson@ouhsc.edu.University of Oklahoma Health Sciences Center, Section of Pulmonary Critical Care & Sleep Medicine, Oklahoma City, OK, USA. Electronic address: Kellie-Jones@ouhsc.edu.University of Oklahoma Health Sciences Center, Lynn Health Science Institute, Oklahoma City, OK, USA. Electronic address: worr@lhsi.net.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32615462

Citation

Raad, Samih, et al. "The Effect of Baclofen On Objective and Subjective Sleep Measures in a Model of Transient Insomnia." Sleep Medicine, vol. 72, 2020, pp. 130-134.
Raad S, Wilkerson M, Jones KR, et al. The effect of baclofen on objective and subjective sleep measures in a model of transient insomnia. Sleep Med. 2020;72:130-134.
Raad, S., Wilkerson, M., Jones, K. R., & Orr, W. C. (2020). The effect of baclofen on objective and subjective sleep measures in a model of transient insomnia. Sleep Medicine, 72, 130-134. https://doi.org/10.1016/j.sleep.2020.03.028
Raad S, et al. The Effect of Baclofen On Objective and Subjective Sleep Measures in a Model of Transient Insomnia. Sleep Med. 2020 Apr 4;72:130-134. PubMed PMID: 32615462.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of baclofen on objective and subjective sleep measures in a model of transient insomnia. AU - Raad,Samih, AU - Wilkerson,Meredith, AU - Jones,Kellie R, AU - Orr,William C, Y1 - 2020/04/04/ PY - 2019/11/24/received PY - 2020/03/11/revised PY - 2020/03/28/accepted PY - 2020/7/3/pubmed PY - 2020/7/3/medline PY - 2020/7/3/entrez KW - Baclofen KW - Insomnia KW - Polysomnography SP - 130 EP - 134 JF - Sleep medicine JO - Sleep Med. VL - 72 N2 - STUDY OBJECTIVES: Insomnia is a common medical complaint. Current pharmacologic treatments have modest efficacy and numerous side effects. Baclofen is a gamma-aminobutyric acid (GABA)b receptor agonist used to treat spasticity in various medical conditions. Several studies noted that baclofen, when used to treat sleep related disorders, resulted in improvement in sleep parameters. Measures of insomnia, however, were not assessed in those studies. To date, baclofen has not been assessed for efficacy in the treatment of insomnia. METHODS: We randomized 20 healthy subjects to baclofen or placebo in a cross over design. All subjects underwent two polysomnograms (PSG) assessing sleep parameters. Baclofen or placebo was given 90 min prior to lights out in random order for each subject. Lights out occurred two hours earlier than the subject's median habitual bedtime. RESULTS: Baclofen resulted in significantly less objective wake after sleep onset and stage 1 sleep, and significantly increased total sleep time (TST), sleep efficiency, and stage 3/4 sleep. There was no effect on sleep onset latency (SOL). Self-report variables indicated significantly less subjective awakenings from sleep and increased subjective sleep quality. There was no effect on subjective TST or subjective SOL. CONCLUSIONS: This study showed that baclofen was superior to placebo with regard to several objective and subjective measures used to assess sleep quality. These data support the notion that baclofen shows promise as an effective hypnotic drug. SN - 1878-5506 UR - https://www.unboundmedicine.com/medline/citation/32615462/The_effect_of_baclofen_on_objective_and_subjective_sleep_measures_in_a_model_of_transient_insomnia L2 - https://linkinghub.elsevier.com/retrieve/pii/S1389-9457(20)30149-0 DB - PRIME DP - Unbound Medicine ER -
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