Tags

Type your tag names separated by a space and hit enter

DaTSCAN (123I-FP-CIT SPECT) imaging in early versus mid and late onset Parkinson's disease: Longitudinal data from the PPMI study.
Parkinsonism Relat Disord. 2020 Jun 22; 77:36-42.PR

Abstract

INTRODUCTION

It has been reported that early onset Parkinson's Disease (PD) patients have a less profound dopaminergic degeneration. The aim of the current study was to determine whether there are longitudinal differences in dopaminergic denervation [signal reduction in 123I-FP-CIT SPECT] in early versus mid and late onset PD.

METHODS

DaTSCAN (123I-FP-CIT SPECT) imaging was acquired at Parkinson's Progression Markers Initiative (PPMI) imaging centers and sent to the imaging core for calculation of striatal binding ratios. Data from the PPMI database of 58 early de novo PD patients (age ≤ 50 years) were compared to those of 362 mid and late onset PD patients (age > 50 years).

RESULTS

Although raw striatal binding ratios were higher in early onset versus mid/late onset PD, especially on the ipsilateral side, such differences were not observed, and were in fact reversed in the contralateral putamen, after age correction. The rate of signal decline was similar between the two groups. Interestingly, based on both raw and age-adjusted data, caudate nucleus and putamen asymmetry (contralateral/ipsilateral ratio) was more pronounced in early onset PD. Striatal asymmetry also significantly correlated with age at onset as a continuous variable.

CONCLUSION

Early onset PD patients exhibited similar rates of decline of dopaminergic denervation compared to mid/late onset PD. These results are not supportive of a more benign disease in this subgroup. The more pronounced asymmetry in early onset PD may however signify a qualitatively different pattern of neurodegeneration compared to mid/late onset PD.

Authors+Show Affiliations

1st Neurology Clinic, Eginition Hospital, Athens University Medical School, Athens, Greece; 2nd Neurology Clinic, Attikon Hospital, Athens University Medical School, Athens, Greece.1st Neurology Clinic, Eginition Hospital, Athens University Medical School, Athens, Greece.1st Neurology Clinic, Eginition Hospital, Athens University Medical School, Athens, Greece; Nuclear Medicine Unit, Attikon Hospital, Athens, Greece.1st Neurology Clinic, Eginition Hospital, Athens University Medical School, Athens, Greece.1st Neurology Clinic, Eginition Hospital, Athens University Medical School, Athens, Greece.1st Neurology Clinic, Eginition Hospital, Athens University Medical School, Athens, Greece; 2nd Neurology Clinic, Attikon Hospital, Athens University Medical School, Athens, Greece.Neurology Clinic, Henry Dunan Hospital, Athens, Greece.2nd Neurology Clinic, Attikon Hospital, Athens University Medical School, Athens, Greece.2nd Neurology Clinic, Attikon Hospital, Athens University Medical School, Athens, Greece.1st Neurology Clinic, Eginition Hospital, Athens University Medical School, Athens, Greece; Neurology Clinic, Philipps University, Marburg, Germany; Parkinson's Disease and Movement Disorders Dept., HYGEIA Hospital, Athens, Greece.Nuclear Medicine Unit, Attikon Hospital, Athens, Greece.1st Neurology Clinic, Eginition Hospital, Athens University Medical School, Athens, Greece. Electronic address: lstefanis@bioacademy.gr.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32615498

Citation

Koros, Christos, et al. "DaTSCAN (123I-FP-CIT SPECT) Imaging in Early Versus Mid and Late Onset Parkinson's Disease: Longitudinal Data From the PPMI Study." Parkinsonism & Related Disorders, vol. 77, 2020, pp. 36-42.
Koros C, Simitsi AM, Prentakis A, et al. DaTSCAN (123I-FP-CIT SPECT) imaging in early versus mid and late onset Parkinson's disease: Longitudinal data from the PPMI study. Parkinsonism Relat Disord. 2020;77:36-42.
Koros, C., Simitsi, A. M., Prentakis, A., Papagiannakis, N., Bougea, A., Pachi, I., Papadimitriou, D., Beratis, I., Papageorgiou, S. G., Stamelou, M., Trapali, X. G., & Stefanis, L. (2020). DaTSCAN (123I-FP-CIT SPECT) imaging in early versus mid and late onset Parkinson's disease: Longitudinal data from the PPMI study. Parkinsonism & Related Disorders, 77, 36-42. https://doi.org/10.1016/j.parkreldis.2020.06.019
Koros C, et al. DaTSCAN (123I-FP-CIT SPECT) Imaging in Early Versus Mid and Late Onset Parkinson's Disease: Longitudinal Data From the PPMI Study. Parkinsonism Relat Disord. 2020 Jun 22;77:36-42. PubMed PMID: 32615498.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - DaTSCAN (123I-FP-CIT SPECT) imaging in early versus mid and late onset Parkinson's disease: Longitudinal data from the PPMI study. AU - Koros,Christos, AU - Simitsi,Athina-Maria, AU - Prentakis,Andreas, AU - Papagiannakis,Nikolaos, AU - Bougea,Anastasia, AU - Pachi,Ioanna, AU - Papadimitriou,Dimitra, AU - Beratis,Ion, AU - Papageorgiou,Sokratis G, AU - Stamelou,Maria, AU - Trapali,Xenia Geronicola, AU - Stefanis,Leonidas, Y1 - 2020/06/22/ PY - 2019/08/26/received PY - 2020/06/10/revised PY - 2020/06/19/accepted PY - 2020/7/3/pubmed PY - 2020/7/3/medline PY - 2020/7/3/entrez KW - 123I-FP-CIT SPECT KW - Caudate nucleus KW - Parkinson's disease KW - Striatal asymmetry SP - 36 EP - 42 JF - Parkinsonism & related disorders JO - Parkinsonism Relat. Disord. VL - 77 N2 - INTRODUCTION: It has been reported that early onset Parkinson's Disease (PD) patients have a less profound dopaminergic degeneration. The aim of the current study was to determine whether there are longitudinal differences in dopaminergic denervation [signal reduction in 123I-FP-CIT SPECT] in early versus mid and late onset PD. METHODS: DaTSCAN (123I-FP-CIT SPECT) imaging was acquired at Parkinson's Progression Markers Initiative (PPMI) imaging centers and sent to the imaging core for calculation of striatal binding ratios. Data from the PPMI database of 58 early de novo PD patients (age ≤ 50 years) were compared to those of 362 mid and late onset PD patients (age > 50 years). RESULTS: Although raw striatal binding ratios were higher in early onset versus mid/late onset PD, especially on the ipsilateral side, such differences were not observed, and were in fact reversed in the contralateral putamen, after age correction. The rate of signal decline was similar between the two groups. Interestingly, based on both raw and age-adjusted data, caudate nucleus and putamen asymmetry (contralateral/ipsilateral ratio) was more pronounced in early onset PD. Striatal asymmetry also significantly correlated with age at onset as a continuous variable. CONCLUSION: Early onset PD patients exhibited similar rates of decline of dopaminergic denervation compared to mid/late onset PD. These results are not supportive of a more benign disease in this subgroup. The more pronounced asymmetry in early onset PD may however signify a qualitatively different pattern of neurodegeneration compared to mid/late onset PD. SN - 1873-5126 UR - https://www.unboundmedicine.com/medline/citation/32615498/DaTSCAN_(123I-FP-CIT_SPECT)_imaging_in_early_versus_mid_and_late_onset_Parkinson's_disease:_Longitudinal_data_from_the_PPMI_study L2 - https://linkinghub.elsevier.com/retrieve/pii/S1353-8020(20)30196-6 DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.