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Efficacy of a vaginal tablet as a Persian medicine product on vulvovaginal candidiasis: a double-blind, randomised, placebo-controlled trial.
Pharm Biol. 2020 Dec; 58(1):574-580.PB

Abstract

Context:

In Persian medicine, topical ingredients such as Rosa damascena Mill. (Rosaceae), are usually recommended for the treatment of uterine diseases. Scientific evaluation of these historical documents can be valuable for finding new potential use in conventional medicine.

Objective:

This clinical trial was performed to determine whether the use of the 'ward' vaginal tablet, which contains Rosa damascena, Punica granatum L. (Punicaceae), Querqus infectoria Oliv. (Fagaceae), Myrtus communis L. (Myrtaceae) and Nardostachys jatamansi (D.Don) DC. (Caprifoliaceae) could alleviate the symptoms of vulvovaginal candidiasis.Materials and methods: A parallel double-blinded placebo-controlled study was done. Eighteen to fifty-year-old women with vulvovaginal candidiasis were divided into the 'ward' and placebo groups, 46 individuals in each group. The 'ward' group received the 'ward' vaginal tablet containing 200 mg of dried extract. Placebo group received a placebo (composed of corn starch and lactose). One tablet was applied through the vagina for 7 consecutive nights.

Results:

Two weeks after medication administration, the vaginal discharge sample of patients was re-cultured; 29 patients (63.045%) in the 'ward' group and 6 (13.04%) patients in the placebo group had negative culture (p < 0.001). All clinical symptoms including itching, irritation, and vaginal discharge were significantly reduced in the 'ward' group compared with the placebo group following the intervention and the follow up (p < 0.05).Discussion and conclusions: The findings suggest the 'ward' vaginal tablet could ameliorate vulvovaginal candidiasis. Future larger studies are recommended due to compare the therapeutic effect of the 'ward' vaginal tablet with common treatments.

Authors+Show Affiliations

Department of Persian Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran.Department of Obstetrics and Gynecology, Tehran University of Medical Sciences, Tehran, Iran.Department of Persian Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran.Department of Persian Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran.Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Department of Pharmacognosy, Faculty of Pharmacy and Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran.Medical Mycology of Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.Razi Hospital Laboratory, Faculty member in medicine, Tehran University of Medical Sciences, Tehran, Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32615837

Citation

Khalilzadeh, Somayyeh, et al. "Efficacy of a Vaginal Tablet as a Persian Medicine Product On Vulvovaginal Candidiasis: a Double-blind, Randomised, Placebo-controlled Trial." Pharmaceutical Biology, vol. 58, no. 1, 2020, pp. 574-580.
Khalilzadeh S, Eftkhar T, Shirbeigi L, et al. Efficacy of a vaginal tablet as a Persian medicine product on vulvovaginal candidiasis: a double-blind, randomised, placebo-controlled trial. Pharm Biol. 2020;58(1):574-580.
Khalilzadeh, S., Eftkhar, T., Shirbeigi, L., Tabarrai, M., Toliyat, T., Fayazmanesh, S., Ghasemi, Z., & Shamohammadi, S. (2020). Efficacy of a vaginal tablet as a Persian medicine product on vulvovaginal candidiasis: a double-blind, randomised, placebo-controlled trial. Pharmaceutical Biology, 58(1), 574-580. https://doi.org/10.1080/13880209.2020.1784236
Khalilzadeh S, et al. Efficacy of a Vaginal Tablet as a Persian Medicine Product On Vulvovaginal Candidiasis: a Double-blind, Randomised, Placebo-controlled Trial. Pharm Biol. 2020;58(1):574-580. PubMed PMID: 32615837.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of a vaginal tablet as a Persian medicine product on vulvovaginal candidiasis: a double-blind, randomised, placebo-controlled trial. AU - Khalilzadeh,Somayyeh, AU - Eftkhar,Tahereh, AU - Shirbeigi,Laila, AU - Tabarrai,Malihe, AU - Toliyat,Tayebeh, AU - Fayazmanesh,Shamim, AU - Ghasemi,Zeinab, AU - Shamohammadi,Safar, PY - 2020/7/4/entrez KW - Vaginitis KW - anti-candida KW - vaginal discharge SP - 574 EP - 580 JF - Pharmaceutical biology JO - Pharm Biol VL - 58 IS - 1 N2 - Context: In Persian medicine, topical ingredients such as Rosa damascena Mill. (Rosaceae), are usually recommended for the treatment of uterine diseases. Scientific evaluation of these historical documents can be valuable for finding new potential use in conventional medicine.Objective: This clinical trial was performed to determine whether the use of the 'ward' vaginal tablet, which contains Rosa damascena, Punica granatum L. (Punicaceae), Querqus infectoria Oliv. (Fagaceae), Myrtus communis L. (Myrtaceae) and Nardostachys jatamansi (D.Don) DC. (Caprifoliaceae) could alleviate the symptoms of vulvovaginal candidiasis.Materials and methods: A parallel double-blinded placebo-controlled study was done. Eighteen to fifty-year-old women with vulvovaginal candidiasis were divided into the 'ward' and placebo groups, 46 individuals in each group. The 'ward' group received the 'ward' vaginal tablet containing 200 mg of dried extract. Placebo group received a placebo (composed of corn starch and lactose). One tablet was applied through the vagina for 7 consecutive nights.Results: Two weeks after medication administration, the vaginal discharge sample of patients was re-cultured; 29 patients (63.045%) in the 'ward' group and 6 (13.04%) patients in the placebo group had negative culture (p < 0.001). All clinical symptoms including itching, irritation, and vaginal discharge were significantly reduced in the 'ward' group compared with the placebo group following the intervention and the follow up (p < 0.05).Discussion and conclusions: The findings suggest the 'ward' vaginal tablet could ameliorate vulvovaginal candidiasis. Future larger studies are recommended due to compare the therapeutic effect of the 'ward' vaginal tablet with common treatments. SN - 1744-5116 UR - https://www.unboundmedicine.com/medline/citation/32615837/Efficacy_of_a_vaginal_tablet_as_a_Persian_medicine_product_on_vulvovaginal_candidiasis:_a_double-blind,_randomised,_placebo-controlled_trial L2 - http://www.tandfonline.com/doi/full/10.1080/13880209.2020.1784236 DB - PRIME DP - Unbound Medicine ER -
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