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Pre-pubertal exposure to ibuprofen impairs sperm parameters in male adult rats and compromises the next generation.
J Toxicol Environ Health A. 2020 Aug 17; 83(15-16):559-572.JT

Abstract

Ibuprofen is one of the most commonly prescribed anti-inflammatory drugs in pediatric practice. This drug inhibits the cyclooxygenase enzyme, reducing the production of prostaglandin, an important mediator on male reproductive function. We examined if pre-pubertal treatment with ibuprofen in male rats can affect the reproductive parameters of these animals in adult life and on their descendants. Male rats (23 days old) received ibuprofen (0; 2.4; 7.2 or 14.3 mg/kg/day), per gavage, from postnatal day (PND) 23 to 53. At sexual maturity, treated males were placed with untreated females for obtaining the next generation (F1). The highest dose of ibuprofen interfered in sexual behavior and reduced the fertility potential of these animals in adulthood. Additionally, the ibuprofen treatment altered the sperm quantity and quality, as evidenced by a decrease in sperm motility and in the daily sperm production in the testis. Testosterone levels were also reduced by pre-pubertal treatment. The paternal treatment with this drug also influenced the reproductive outcomes of progeny. The male offspring from males treated exhibited acceleration in sperm transit time in the epididymis and the number and volume of Leydig cell nuclei were decreased, while the estrous cyclicity was displayed and the fertility potential reduced in the female offspring. The pre-pubertal ibuprofen-treatment caused negative reproductive impacts in adulthood, compromising sperm quality and quantity, as well as interfered in the reproductive outcomes of the next generation.

Authors+Show Affiliations

Department of Structural and Functional Biology, Institute of Biosciences of Botucatu, Univ. Estadual Paulista - Botucatu (UNESP) , São Paulo, Brazil.Department of Structural and Functional Biology, Institute of Biosciences of Botucatu, Univ. Estadual Paulista - Botucatu (UNESP) , São Paulo, Brazil.Department of Structural and Functional Biology, Institute of Biosciences of Botucatu, Univ. Estadual Paulista - Botucatu (UNESP) , São Paulo, Brazil.Department of Structural and Functional Biology, Institute of Biosciences of Botucatu, Univ. Estadual Paulista - Botucatu (UNESP) , São Paulo, Brazil.Department of Structural and Functional Biology, Institute of Biosciences of Botucatu, Univ. Estadual Paulista - Botucatu (UNESP) , São Paulo, Brazil.Department of Structural and Functional Biology, Institute of Biosciences of Botucatu, Univ. Estadual Paulista - Botucatu (UNESP) , São Paulo, Brazil.Department of Structural and Functional Biology, Institute of Biosciences of Botucatu, Univ. Estadual Paulista - Botucatu (UNESP) , São Paulo, Brazil.Department of Structural and Functional Biology, Institute of Biosciences of Botucatu, Univ. Estadual Paulista - Botucatu (UNESP) , São Paulo, Brazil.College of Health Science, Federal University of Grande Dourados - Dourados , Mato grosso do Sul, Brazil.Department of Structural and Functional Biology, Institute of Biosciences of Botucatu, Univ. Estadual Paulista - Botucatu (UNESP) , São Paulo, Brazil. Department of Structural and Functional Biology, Institute of Biosciences of Botucatu, São Paulo State University (UNESP) , Botucatu, Brazil.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32615883

Citation

Barbosa, Mariana Gazoli, et al. "Pre-pubertal Exposure to Ibuprofen Impairs Sperm Parameters in Male Adult Rats and Compromises the Next Generation." Journal of Toxicology and Environmental Health. Part A, vol. 83, no. 15-16, 2020, pp. 559-572.
Barbosa MG, Jorge BC, Stein J, et al. Pre-pubertal exposure to ibuprofen impairs sperm parameters in male adult rats and compromises the next generation. J Toxicol Environ Health Part A. 2020;83(15-16):559-572.
Barbosa, M. G., Jorge, B. C., Stein, J., Santos Ferreira, D. A., Barreto, A. C. D. S., Reis, A. C. C., Moreira, S. D. S., Inocencio, L. C. L., Macorini, L. F. B., & Arena, A. C. (2020). Pre-pubertal exposure to ibuprofen impairs sperm parameters in male adult rats and compromises the next generation. Journal of Toxicology and Environmental Health. Part A, 83(15-16), 559-572. https://doi.org/10.1080/15287394.2020.1786483
Barbosa MG, et al. Pre-pubertal Exposure to Ibuprofen Impairs Sperm Parameters in Male Adult Rats and Compromises the Next Generation. J Toxicol Environ Health Part A. 2020 Aug 17;83(15-16):559-572. PubMed PMID: 32615883.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pre-pubertal exposure to ibuprofen impairs sperm parameters in male adult rats and compromises the next generation. AU - Barbosa,Mariana Gazoli, AU - Jorge,Bárbara Campos, AU - Stein,Julia, AU - Santos Ferreira,Dayana Agnes, AU - Barreto,Ana Carolina da Silva, AU - Reis,Ana Carolina Casali, AU - Moreira,Suyane Da Silva, AU - Inocencio,Leonardo Cesar De Lima, AU - Macorini,Luis Fernando Benitez, AU - Arena,Arielle Cristina, Y1 - 2020/07/02/ PY - 2020/7/4/pubmed PY - 2020/7/4/medline PY - 2020/7/4/entrez KW - Non-steroidal anti-inflammatory KW - multigenerational effects KW - peripuberty KW - prostaglandin KW - sperm SP - 559 EP - 572 JF - Journal of toxicology and environmental health. Part A JO - J. Toxicol. Environ. Health Part A VL - 83 IS - 15-16 N2 - Ibuprofen is one of the most commonly prescribed anti-inflammatory drugs in pediatric practice. This drug inhibits the cyclooxygenase enzyme, reducing the production of prostaglandin, an important mediator on male reproductive function. We examined if pre-pubertal treatment with ibuprofen in male rats can affect the reproductive parameters of these animals in adult life and on their descendants. Male rats (23 days old) received ibuprofen (0; 2.4; 7.2 or 14.3 mg/kg/day), per gavage, from postnatal day (PND) 23 to 53. At sexual maturity, treated males were placed with untreated females for obtaining the next generation (F1). The highest dose of ibuprofen interfered in sexual behavior and reduced the fertility potential of these animals in adulthood. Additionally, the ibuprofen treatment altered the sperm quantity and quality, as evidenced by a decrease in sperm motility and in the daily sperm production in the testis. Testosterone levels were also reduced by pre-pubertal treatment. The paternal treatment with this drug also influenced the reproductive outcomes of progeny. The male offspring from males treated exhibited acceleration in sperm transit time in the epididymis and the number and volume of Leydig cell nuclei were decreased, while the estrous cyclicity was displayed and the fertility potential reduced in the female offspring. The pre-pubertal ibuprofen-treatment caused negative reproductive impacts in adulthood, compromising sperm quality and quantity, as well as interfered in the reproductive outcomes of the next generation. SN - 1528-7394 UR - https://www.unboundmedicine.com/medline/citation/32615883/Pre-pubertal_exposure_to_ibuprofen_impairs_sperm_parameters_in_male_adult_rats_and_compromises_the_next_generation L2 - http://www.tandfonline.com/doi/full/10.1080/15287394.2020.1786483 DB - PRIME DP - Unbound Medicine ER -
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