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Total nucleated cell counts are driving clinician's choice rather than cryopreservation period: Lesson for cord blood banks.
Transfus Apher Sci. 2020 Jun 25 [Online ahead of print]TA

Abstract

According to the increase in both the number of cryopreserved cord blood (CB) units and the cryopreservation period for each CB unit in the largest public CB bank in Korea, we are pursuing greater efficiency in CB bank management. Thus, we analyzed whether the cryopreservation period has a negative impact on the selection of CB units for CB transplantation (CBT). Until December 2019, 468 CB units were used for transplantation. The cryopreservation period, total nucleated cell (TNC), and CD34+ cell counts were analyzed among the CB units according to the CBT-year and the donation year. The results showed that the cryopreservation period was increased in recent CBT-year groups. The transplanted CB units showed similar TNC counts irrespective of the donation year, and the mean TNC count was 13.9 × 108/unit. CB units cryopreserved for a relatively long period were transplanted consistently. The mean TNC count of CB units cryopreserved for over 10 years was 16.4 × 108/unit. The mean CD34+ cell counts were not significantly different among the CB units transplanted after CBT-2013 and among the CB units donated after CBT-2011. Through an analysis of the CB units selected by clinicians for CBT, this study revealed that clinicians placed more weight on the TNC counts than on the cryopreservation period of cryopreserved CB units. Therefore, the minimum TNC count of CB units suitable for cryopreservation should be increased up to 13.0 × 108/unit to balance the satisfaction of clinicians' needs with the efficiency of the CB bank.

Authors+Show Affiliations

Department of Laboratory Medicine, National Medical Center, Seoul, South Korea.Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, South Korea; Department of Laboratory Medicine, SMG-SNU Boramae Medical Center, Seoul, South Korea; Seoul Metropolitan Government Public Cord Blood Bank (Allcord), Seoul, South Korea.Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, South Korea; Department of Laboratory Medicine, SMG-SNU Boramae Medical Center, Seoul, South Korea; Seoul Metropolitan Government Public Cord Blood Bank (Allcord), Seoul, South Korea.Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, South Korea.Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, South Korea; Department of Laboratory Medicine, SMG-SNU Boramae Medical Center, Seoul, South Korea; Seoul Metropolitan Government Public Cord Blood Bank (Allcord), Seoul, South Korea.Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, South Korea; Department of Laboratory Medicine, SMG-SNU Boramae Medical Center, Seoul, South Korea; Seoul Metropolitan Government Public Cord Blood Bank (Allcord), Seoul, South Korea.Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, South Korea; Department of Laboratory Medicine, SMG-SNU Boramae Medical Center, Seoul, South Korea; Seoul Metropolitan Government Public Cord Blood Bank (Allcord), Seoul, South Korea. Electronic address: Jeannie@snu.ac.kr.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32616364

Citation

Lee, Hye Ryun, et al. "Total Nucleated Cell Counts Are Driving Clinician's Choice Rather Than Cryopreservation Period: Lesson for Cord Blood Banks." Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis, 2020, p. 102849.
Lee HR, Roh EY, Kim N, et al. Total nucleated cell counts are driving clinician's choice rather than cryopreservation period: Lesson for cord blood banks. Transfus Apher Sci. 2020.
Lee, H. R., Roh, E. Y., Kim, N., Song, E. Y., Park, H., Yoon, J. H., & Shin, S. (2020). Total nucleated cell counts are driving clinician's choice rather than cryopreservation period: Lesson for cord blood banks. Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis, 102849. https://doi.org/10.1016/j.transci.2020.102849
Lee HR, et al. Total Nucleated Cell Counts Are Driving Clinician's Choice Rather Than Cryopreservation Period: Lesson for Cord Blood Banks. Transfus Apher Sci. 2020 Jun 25;102849. PubMed PMID: 32616364.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Total nucleated cell counts are driving clinician's choice rather than cryopreservation period: Lesson for cord blood banks. AU - Lee,Hye Ryun, AU - Roh,Eun Youn, AU - Kim,Namhee, AU - Song,Eun Young, AU - Park,Hyunwoong, AU - Yoon,Jong Hyun, AU - Shin,Sue, Y1 - 2020/06/25/ PY - 2020/03/02/received PY - 2020/06/02/revised PY - 2020/06/03/accepted PY - 2020/7/4/entrez KW - Cord blood (CB) KW - Cord blood (CB) bank KW - Cord blood transplantation KW - Cryopreservation period KW - Total nucleated cells (TNC) count SP - 102849 EP - 102849 JF - Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis JO - Transfus. Apher. Sci. N2 - According to the increase in both the number of cryopreserved cord blood (CB) units and the cryopreservation period for each CB unit in the largest public CB bank in Korea, we are pursuing greater efficiency in CB bank management. Thus, we analyzed whether the cryopreservation period has a negative impact on the selection of CB units for CB transplantation (CBT). Until December 2019, 468 CB units were used for transplantation. The cryopreservation period, total nucleated cell (TNC), and CD34+ cell counts were analyzed among the CB units according to the CBT-year and the donation year. The results showed that the cryopreservation period was increased in recent CBT-year groups. The transplanted CB units showed similar TNC counts irrespective of the donation year, and the mean TNC count was 13.9 × 108/unit. CB units cryopreserved for a relatively long period were transplanted consistently. The mean TNC count of CB units cryopreserved for over 10 years was 16.4 × 108/unit. The mean CD34+ cell counts were not significantly different among the CB units transplanted after CBT-2013 and among the CB units donated after CBT-2011. Through an analysis of the CB units selected by clinicians for CBT, this study revealed that clinicians placed more weight on the TNC counts than on the cryopreservation period of cryopreserved CB units. Therefore, the minimum TNC count of CB units suitable for cryopreservation should be increased up to 13.0 × 108/unit to balance the satisfaction of clinicians' needs with the efficiency of the CB bank. SN - 1473-0502 UR - https://www.unboundmedicine.com/medline/citation/32616364/Total_nucleated_cell_counts_are_driving_clinician's_choice_rather_than_cryopreservation_period:_Lesson_for_cord_blood_banks L2 - https://linkinghub.elsevier.com/retrieve/pii/S1473-0502(20)30152-X DB - PRIME DP - Unbound Medicine ER -
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