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Molecular mechanisms of human herpes viruses inferring with host immune surveillance.
J Immunother Cancer. 2020 Jul; 8(2)JI

Abstract

Several human herpes viruses (HHVs) exert oncogenic potential leading to malignant transformation of infected cells and/or tissues. The molecular processes induced by viral-encoded molecules including microRNAs, peptides, and proteins contributing to immune evasion of the infected host cells are equal to the molecular processes of immune evasion mediated by tumor cells independently of viral infections. Such major immune evasion strategies include (1) the downregulation of proinflammatory cytokines/chemokines as well as the induction of anti-inflammatory cytokines/chemokines, (2) the downregulation of major histocompatibility complex (MHC) class Ia directly as well as indirectly by downregulation of the components involved in the antigen processing, and (3) the downregulation of stress-induced ligands for activating receptors on immune effector cells with NKG2D leading the way. Furthermore, (4) immune modulatory molecules like MHC class Ib molecules and programmed cell death1 ligand 1 can be upregulated on infections with certain herpes viruses. This review article focuses on the known molecular mechanisms of HHVs modulating the above-mentioned possibilities for immune surveillance and even postulates a temporal order linking regular tumor immunology with basic virology and offering putatively novel insights for targeting HHVs.

Authors+Show Affiliations

Institute for Medical Immunology, Martin-Luther-Universitat Halle-Wittenberg, Halle (Saale), Germany simon.jasinski@uk-halle.de.Immunology & Cancer Research Center, Hebrew University of Jerusalem, Jerusalem, Israel.Institute for Medical Immunology, Martin-Luther-Universitat Halle-Wittenberg, Halle (Saale), Germany.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32616556

Citation

Jasinski-Bergner, Simon, et al. "Molecular Mechanisms of Human Herpes Viruses Inferring With Host Immune Surveillance." Journal for Immunotherapy of Cancer, vol. 8, no. 2, 2020.
Jasinski-Bergner S, Mandelboim O, Seliger B. Molecular mechanisms of human herpes viruses inferring with host immune surveillance. J Immunother Cancer. 2020;8(2).
Jasinski-Bergner, S., Mandelboim, O., & Seliger, B. (2020). Molecular mechanisms of human herpes viruses inferring with host immune surveillance. Journal for Immunotherapy of Cancer, 8(2). https://doi.org/10.1136/jitc-2020-000841
Jasinski-Bergner S, Mandelboim O, Seliger B. Molecular Mechanisms of Human Herpes Viruses Inferring With Host Immune Surveillance. J Immunother Cancer. 2020;8(2) PubMed PMID: 32616556.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Molecular mechanisms of human herpes viruses inferring with host immune surveillance. AU - Jasinski-Bergner,Simon, AU - Mandelboim,Ofer, AU - Seliger,Barbara, PY - 2020/06/03/accepted PY - 2020/7/4/entrez PY - 2020/7/4/pubmed PY - 2020/7/4/medline KW - antigen presentation KW - immune tolerance KW - immunity KW - immunomodulation KW - immunotherapy JF - Journal for immunotherapy of cancer JO - J Immunother Cancer VL - 8 IS - 2 N2 - Several human herpes viruses (HHVs) exert oncogenic potential leading to malignant transformation of infected cells and/or tissues. The molecular processes induced by viral-encoded molecules including microRNAs, peptides, and proteins contributing to immune evasion of the infected host cells are equal to the molecular processes of immune evasion mediated by tumor cells independently of viral infections. Such major immune evasion strategies include (1) the downregulation of proinflammatory cytokines/chemokines as well as the induction of anti-inflammatory cytokines/chemokines, (2) the downregulation of major histocompatibility complex (MHC) class Ia directly as well as indirectly by downregulation of the components involved in the antigen processing, and (3) the downregulation of stress-induced ligands for activating receptors on immune effector cells with NKG2D leading the way. Furthermore, (4) immune modulatory molecules like MHC class Ib molecules and programmed cell death1 ligand 1 can be upregulated on infections with certain herpes viruses. This review article focuses on the known molecular mechanisms of HHVs modulating the above-mentioned possibilities for immune surveillance and even postulates a temporal order linking regular tumor immunology with basic virology and offering putatively novel insights for targeting HHVs. SN - 2051-1426 UR - https://www.unboundmedicine.com/medline/citation/32616556/Molecular_mechanisms_of_human_herpes_viruses_inferring_with_host_immune_surveillance L2 - https://jitc.bmj.com/cgi/pmidlookup?view=long&pmid=32616556 DB - PRIME DP - Unbound Medicine ER -
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