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Unveiling antimicrobial and anticancerous behavior of AuNPs and AgNPs moderated by rhizome extracts of Curcuma longa from diverse altitudes of Himalaya.
Sci Rep. 2020 Jul 02; 10(1):10934.SR

Abstract

Conservative remedies have a gray history worldwide and these provide productive and pertinent tools to tackle ailments. Also, the high altitude areas of Indian Himalayas with their wealthy biodiversity anchorage around 2000 plant species. Ensuing study demonstrates the synthesis of Silver (Ag) and gold (Au) nanoparticles (NPs) and utilizes one of the medicaments Curcuma longa of Indian Himalayas collected from different altitudes. For the same, turmeric rhizome extracts have been prepared from the aforesaid medicament and its anticancer activity and antimicrobial potential have been evaluated. Formation of Ag and Au nanoparticles was realized via UV-Vis spectroscopy and transmission electron microscope (TEM) confirmed size of the NPs. Antibacterial activity has been checked against Bacillus subtilis and Escherichia coli. The anticancer prospective has been observed against A549 and PC3 cell lines of both Au and Ag NPs and the cytotoxicity on PC3 and A549 cell lines was assessed using MTT assay. Results revealed higher amount of biochemicals, antibacterial and anticancer activity in Ag and Au NPs synthesized from rhizome extract collected from highest altitude. For the first time impact of altitudinal variations on phytochemicals and nanoparticles has been reported which have significant effect on its antimicrobial and anticancerous activity.

Authors+Show Affiliations

School of Biological and Environmental Sciences, Shoolini University, Solan, 173212, India. mamta131526@gmail.com.School of Biological and Environmental Sciences, Shoolini University, Solan, 173212, India.School of Chemistry, Shoolini University, Solan, 173212, India. Himalayan Center of Excellence in Nanotechnology, Shoolini University, Solan, 173212, India.School of Biotechnology and Applied Sciences, Shoolini University, Solan, India.School of Physics and Materials Sciences, Shoolini University, Solan, India. rajeshsharma@shooliniuniversity.com.Center for Advanced Biomaterials for Healthcare, Italian Institute of Technology, 80125, Naples, Italy.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32616751

Citation

Sharma, Mamta, et al. "Unveiling Antimicrobial and Anticancerous Behavior of AuNPs and AgNPs Moderated By Rhizome Extracts of Curcuma Longa From Diverse Altitudes of Himalaya." Scientific Reports, vol. 10, no. 1, 2020, p. 10934.
Sharma M, Monika , Thakur P, et al. Unveiling antimicrobial and anticancerous behavior of AuNPs and AgNPs moderated by rhizome extracts of Curcuma longa from diverse altitudes of Himalaya. Sci Rep. 2020;10(1):10934.
Sharma, M., Monika, ., Thakur, P., Saini, R. V., Kumar, R., & Torino, E. (2020). Unveiling antimicrobial and anticancerous behavior of AuNPs and AgNPs moderated by rhizome extracts of Curcuma longa from diverse altitudes of Himalaya. Scientific Reports, 10(1), 10934. https://doi.org/10.1038/s41598-020-67673-4
Sharma M, et al. Unveiling Antimicrobial and Anticancerous Behavior of AuNPs and AgNPs Moderated By Rhizome Extracts of Curcuma Longa From Diverse Altitudes of Himalaya. Sci Rep. 2020 Jul 2;10(1):10934. PubMed PMID: 32616751.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Unveiling antimicrobial and anticancerous behavior of AuNPs and AgNPs moderated by rhizome extracts of Curcuma longa from diverse altitudes of Himalaya. AU - Sharma,Mamta, AU - Monika,, AU - Thakur,Pankaj, AU - Saini,Reena V, AU - Kumar,Rajesh, AU - Torino,Enza, Y1 - 2020/07/02/ PY - 2020/02/26/received PY - 2020/05/18/accepted PY - 2020/7/4/entrez PY - 2020/7/4/pubmed PY - 2020/7/4/medline SP - 10934 EP - 10934 JF - Scientific reports JO - Sci Rep VL - 10 IS - 1 N2 - Conservative remedies have a gray history worldwide and these provide productive and pertinent tools to tackle ailments. Also, the high altitude areas of Indian Himalayas with their wealthy biodiversity anchorage around 2000 plant species. Ensuing study demonstrates the synthesis of Silver (Ag) and gold (Au) nanoparticles (NPs) and utilizes one of the medicaments Curcuma longa of Indian Himalayas collected from different altitudes. For the same, turmeric rhizome extracts have been prepared from the aforesaid medicament and its anticancer activity and antimicrobial potential have been evaluated. Formation of Ag and Au nanoparticles was realized via UV-Vis spectroscopy and transmission electron microscope (TEM) confirmed size of the NPs. Antibacterial activity has been checked against Bacillus subtilis and Escherichia coli. The anticancer prospective has been observed against A549 and PC3 cell lines of both Au and Ag NPs and the cytotoxicity on PC3 and A549 cell lines was assessed using MTT assay. Results revealed higher amount of biochemicals, antibacterial and anticancer activity in Ag and Au NPs synthesized from rhizome extract collected from highest altitude. For the first time impact of altitudinal variations on phytochemicals and nanoparticles has been reported which have significant effect on its antimicrobial and anticancerous activity. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/32616751/Unveiling_antimicrobial_and_anticancerous_behavior_of_AuNPs_and_AgNPs_moderated_by_rhizome_extracts_of_Curcuma_longa_from_diverse_altitudes_of_Himalaya L2 - http://dx.doi.org/10.1038/s41598-020-67673-4 DB - PRIME DP - Unbound Medicine ER -
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