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Tryptophan Metabolism, Regulatory T Cells, and Inflammatory Bowel Disease: A Mini Review.
Mediators Inflamm. 2020; 2020:9706140.MI

Abstract

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract resulting from the homeostasis imbalance of intestinal microenvironment, immune dysfunction, environmental and genetic factors, and so on. This disease is associated with multiple immune cells including regulatory T cells (Tregs). Tregs are a subset of T cells regulating the function of various immune cells to induce immune tolerance and maintain intestinal immune homeostasis. Tregs are correlated with the initiation and progression of IBD; therefore, strategies that affect the differentiation and function of Tregs may be promising for the prevention of IBD-associated pathology. It is worth noting that tryptophan (Trp) metabolism is effective in inducing the differentiation of Tregs through microbiota-mediated degradation and kynurenine pathway (KP), which is important for maintaining the function of Tregs. Interestingly, patients with IBD show Trp metabolism disorder in the pathological process, including changes in the concentrations of Trp and its metabolites and alteration in the activities of related catalytic enzymes. Thus, manipulation of Treg differentiation through Trp metabolism may provide a potential target for prevention of IBD. The purpose of this review is to highlight the relationship between Trp metabolism and Treg differentiation and the role of this interaction in the pathogenesis of IBD.

Authors+Show Affiliations

College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China. Jiangsu Co-Innovation Center for Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China. Joint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education of China, Yangzhou University, Yangzhou, Jiangsu 225009, China.College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China. Jiangsu Co-Innovation Center for Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China. Joint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education of China, Yangzhou University, Yangzhou, Jiangsu 225009, China.College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China. Jiangsu Co-Innovation Center for Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China. Joint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education of China, Yangzhou University, Yangzhou, Jiangsu 225009, China.College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China. Jiangsu Co-Innovation Center for Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China. Joint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education of China, Yangzhou University, Yangzhou, Jiangsu 225009, China.College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China. Jiangsu Co-Innovation Center for Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China. Joint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education of China, Yangzhou University, Yangzhou, Jiangsu 225009, China.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32617076

Citation

Ding, Xueyan, et al. "Tryptophan Metabolism, Regulatory T Cells, and Inflammatory Bowel Disease: a Mini Review." Mediators of Inflammation, vol. 2020, 2020, p. 9706140.
Ding X, Bin P, Wu W, et al. Tryptophan Metabolism, Regulatory T Cells, and Inflammatory Bowel Disease: A Mini Review. Mediators Inflamm. 2020;2020:9706140.
Ding, X., Bin, P., Wu, W., Chang, Y., & Zhu, G. (2020). Tryptophan Metabolism, Regulatory T Cells, and Inflammatory Bowel Disease: A Mini Review. Mediators of Inflammation, 2020, 9706140. https://doi.org/10.1155/2020/9706140
Ding X, et al. Tryptophan Metabolism, Regulatory T Cells, and Inflammatory Bowel Disease: a Mini Review. Mediators Inflamm. 2020;2020:9706140. PubMed PMID: 32617076.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tryptophan Metabolism, Regulatory T Cells, and Inflammatory Bowel Disease: A Mini Review. AU - Ding,Xueyan, AU - Bin,Peng, AU - Wu,Wenwen, AU - Chang,Yajie, AU - Zhu,Guoqiang, Y1 - 2020/06/12/ PY - 2020/04/08/received PY - 2020/05/26/accepted PY - 2020/7/4/entrez PY - 2020/7/4/pubmed PY - 2020/7/4/medline SP - 9706140 EP - 9706140 JF - Mediators of inflammation JO - Mediators Inflamm. VL - 2020 N2 - Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract resulting from the homeostasis imbalance of intestinal microenvironment, immune dysfunction, environmental and genetic factors, and so on. This disease is associated with multiple immune cells including regulatory T cells (Tregs). Tregs are a subset of T cells regulating the function of various immune cells to induce immune tolerance and maintain intestinal immune homeostasis. Tregs are correlated with the initiation and progression of IBD; therefore, strategies that affect the differentiation and function of Tregs may be promising for the prevention of IBD-associated pathology. It is worth noting that tryptophan (Trp) metabolism is effective in inducing the differentiation of Tregs through microbiota-mediated degradation and kynurenine pathway (KP), which is important for maintaining the function of Tregs. Interestingly, patients with IBD show Trp metabolism disorder in the pathological process, including changes in the concentrations of Trp and its metabolites and alteration in the activities of related catalytic enzymes. Thus, manipulation of Treg differentiation through Trp metabolism may provide a potential target for prevention of IBD. The purpose of this review is to highlight the relationship between Trp metabolism and Treg differentiation and the role of this interaction in the pathogenesis of IBD. SN - 1466-1861 UR - https://www.unboundmedicine.com/medline/citation/32617076/Tryptophan_Metabolism,_Regulatory_T_Cells,_and_Inflammatory_Bowel_Disease:_A_Mini_Review L2 - https://doi.org/10.1155/2020/9706140 DB - PRIME DP - Unbound Medicine ER -
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