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The Gut-Eye Axis: Lessons Learned from Murine Models.
Ophthalmol Ther. 2020 Sep; 9(3):499-513.OT

Abstract

A healthy gut microbiota is essential in maintaining the human body in a homeostatic state by its functions in digestion and immune tolerance. Under states of aberrant microbial composition or function (dysbiosis), the gut microbiota induces systemic inflammation that can lead to the onset of many diseases. In this review, we describe some evidence, largely from rodent studies, that supports the possible role of a dysbiotic gut microbiota in the onset and exacerbation of ocular diseases, primarily diabetic retinopathy, age-related macular degeneration, choroidal neovascularization, and uveitis. Furthermore, we examine several potential therapeutic measures that show promise in restoring the gut microbiota to a eubiotic state, preventing the aforementioned disease pathologies.

Authors+Show Affiliations

Department of Ophthalmology and Visual Sciences, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.Department of Ophthalmology and Visual Sciences, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. mariagrant@uabmc.edu.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32617914

Citation

Floyd, Jason L., and Maria B. Grant. "The Gut-Eye Axis: Lessons Learned From Murine Models." Ophthalmology and Therapy, vol. 9, no. 3, 2020, pp. 499-513.
Floyd JL, Grant MB. The Gut-Eye Axis: Lessons Learned from Murine Models. Ophthalmol Ther. 2020;9(3):499-513.
Floyd, J. L., & Grant, M. B. (2020). The Gut-Eye Axis: Lessons Learned from Murine Models. Ophthalmology and Therapy, 9(3), 499-513. https://doi.org/10.1007/s40123-020-00278-2
Floyd JL, Grant MB. The Gut-Eye Axis: Lessons Learned From Murine Models. Ophthalmol Ther. 2020;9(3):499-513. PubMed PMID: 32617914.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Gut-Eye Axis: Lessons Learned from Murine Models. AU - Floyd,Jason L, AU - Grant,Maria B, Y1 - 2020/07/02/ PY - 2020/05/13/received PY - 2020/7/4/pubmed PY - 2020/7/4/medline PY - 2020/7/4/entrez KW - Age-related macular degeneration KW - Choroidal neovascularization KW - Diabetic retinopathy KW - Diet KW - Fecal microbiota transplant KW - Glaucoma KW - Gut microbiota KW - Intermittent fasting KW - Probiotic KW - Uveitis SP - 499 EP - 513 JF - Ophthalmology and therapy JO - Ophthalmol Ther VL - 9 IS - 3 N2 - A healthy gut microbiota is essential in maintaining the human body in a homeostatic state by its functions in digestion and immune tolerance. Under states of aberrant microbial composition or function (dysbiosis), the gut microbiota induces systemic inflammation that can lead to the onset of many diseases. In this review, we describe some evidence, largely from rodent studies, that supports the possible role of a dysbiotic gut microbiota in the onset and exacerbation of ocular diseases, primarily diabetic retinopathy, age-related macular degeneration, choroidal neovascularization, and uveitis. Furthermore, we examine several potential therapeutic measures that show promise in restoring the gut microbiota to a eubiotic state, preventing the aforementioned disease pathologies. SN - 2193-8245 UR - https://www.unboundmedicine.com/medline/citation/32617914/The_Gut-Eye_Axis:_Lessons_Learned_from_Murine_Models L2 - https://dx.doi.org/10.1007/s40123-020-00278-2 DB - PRIME DP - Unbound Medicine ER -
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