TY - JOUR T1 - Long-term antithrombotic management patterns in Asian patients with acute coronary syndrome: 2-year observations from the EPICOR Asia study. AU - Zheng,Bo, AU - Huo,Yong, AU - Lee,Stephen W-L, AU - Sawhney,Jitendra P S, AU - Kim,Hyo-Soo, AU - Krittayaphong,Rungroj, AU - Pocock,Stuart J, AU - Nhan,Vo T, AU - Alonso Garcia,Angeles, AU - Chin,Chee Tang, AU - Jiang,Jie, AU - Jan,Stephen, AU - Vega,Ana Maria, AU - Hayashi,Nobuya, AU - Ong,Tiong K, Y1 - 2020/07/02/ PY - 2020/04/30/received PY - 2020/05/20/revised PY - 2020/05/21/accepted PY - 2020/7/4/pubmed PY - 2020/7/4/medline PY - 2020/7/4/entrez KW - EPICOR KW - acute coronary care antithrombotic management patterns KW - acute coronary syndrome KW - observational SP - 999 EP - 1008 JF - Clinical cardiology JO - Clin Cardiol VL - 43 IS - 9 N2 - BACKGROUND: Despite guideline recommendations, dual antiplatelet therapy (DAPT) is frequently used for longer than 1 year after an acute coronary syndrome (ACS) event. In Asia, information on antithrombotic management patterns (AMPs), including DAPT post discharge, is sparse. This analysis evaluated real-world AMPs up to 2 years post discharge for ACS. HYPOTHESIS: There is wide variability in AMP use for ACS management in Asia. METHODS: EPICOR Asia (NCT01361386) is a prospective observational study of patients discharged after hospitalization for an ACS in eight countries/regions in Asia, followed up for 2 years. Here, we describe AMPs used and present an exploratory analysis of characteristics and outcomes in patients who received DAPT for ≤12 months post discharge compared with >12 months. RESULTS: Data were available for 12 922 patients; of 11 639 patients discharged on DAPT, 2364 (20.3%) received DAPT for ≤12 months and 9275 (79.7%) for >12 months, with approximately 60% still on DAPT at 2 years. Patients who received DAPT for >12 months were more likely to be younger, obese, lower Killip class, resident in India (vs China), and to have received invasive reperfusion. Clinical event rates during year 2 of follow-up were lower in patients with DAPT >12 vs ≤12 months, but no causal association can be implied in this non-randomized study. CONCLUSIONS: Most ACS patients remained on DAPT up to 1 year, in accordance with current guidelines, and over half remained on DAPT at 2 years post discharge. Patients not on DAPT at 12 months are a higher risk group requiring careful monitoring. SN - 1932-8737 UR - https://www.unboundmedicine.com/medline/citation/32618009/Long_term_antithrombotic_management_patterns_in_Asian_patients_with_acute_coronary_syndrome:_2_year_observations_from_the_EPICOR_Asia_study_ L2 - https://doi.org/10.1002/clc.23400 DB - PRIME DP - Unbound Medicine ER -