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The AutGO Initiative: A Conceptual Framework for Developing Genetics-Outcomes Research Hypotheses.
Autism Res. 2020 Jul 03 [Online ahead of print]AR

Abstract

The increasing emphasis on translational approaches to complex neuropsychiatric and neurodevelopmental conditions research requires scientists from a broad range of disciplines to build dynamic collaborations when formulating hypotheses and framing study designs. The need to integrate the knowledge and perspectives not only from multiple scientific silos but also from the populations impacted by these conditions presents a significant challenge to researchers, particularly for a heterogeneous condition like autism. As one path toward addressing these challenges, we have previously introduced Autism Genetics Outcomes (AutGO), an initiative to support broad stakeholder partnerships and promote a new integrated concept called GO (i.e., research approaches that draw on both genetics and clinical outcomes perspectives). Herein, we developed a workflow for collecting stakeholders' feedback toward the development of a GO hypothesis. AutGO is an evolving initiative, and here we describe how its three essential components (conceptual framework, applicability, and implementation) have been developed. As a proof-of-concept, the AutGO team sought to demonstrate how a GO hypothesis could be developed using a semi-structured literature review workflow. We also developed a prototype from published reports and formulated a GO hypothesis for autism. Rather than seeking community stakeholder input after a research project is conceptualized and designed, the developed conceptual framework demonstrates the feasibility of formulating scientific hypotheses by engaging stakeholders in retrospective semi-structured literature reviews. The presented workflow, prototype, and discussed recommendations will bring awareness in the autism research community about the benefits of applying the GO approach in order to promote translational aspects in genetics research. LAY

SUMMARY:

We used a community-based engagement approach to develop AutGO (Autism Genetics Outcomes), an initiative to establish stakeholder partnerships and to promote research approaches (we refer to as GO) that draw on both genetics and clinical outcomes perspectives. Specifically, we developed a conceptual framework that includes a literature review process for developing GO hypotheses and stakeholder feedback collection protocol. Our work will bring awareness in the autism research community about the benefits of integrating patient perspectives in genetics research.

Authors+Show Affiliations

Children's Mercy Hospital, Kansas City, MO, USA. University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA.Children's Mercy Hospital, Kansas City, MO, USA.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32618145

Citation

Talebizadeh, Zohreh, et al. "The AutGO Initiative: a Conceptual Framework for Developing Genetics-Outcomes Research Hypotheses." Autism Research : Official Journal of the International Society for Autism Research, 2020.
Talebizadeh Z, Shah A, AutGO Working Group. The AutGO Initiative: A Conceptual Framework for Developing Genetics-Outcomes Research Hypotheses. Autism Res. 2020.
Talebizadeh, Z., & Shah, A. (2020). The AutGO Initiative: A Conceptual Framework for Developing Genetics-Outcomes Research Hypotheses. Autism Research : Official Journal of the International Society for Autism Research. https://doi.org/10.1002/aur.2331
Talebizadeh Z, Shah A, AutGO Working Group. The AutGO Initiative: a Conceptual Framework for Developing Genetics-Outcomes Research Hypotheses. Autism Res. 2020 Jul 3; PubMed PMID: 32618145.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The AutGO Initiative: A Conceptual Framework for Developing Genetics-Outcomes Research Hypotheses. AU - Talebizadeh,Zohreh, AU - Shah,Ayten, AU - ,, Y1 - 2020/07/03/ PY - 2019/12/10/received PY - 2020/04/23/revised PY - 2020/04/27/accepted PY - 2020/7/4/entrez KW - autism KW - conceptual framework; genetics KW - engagement KW - outcomes KW - stakeholders KW - translational research JF - Autism research : official journal of the International Society for Autism Research JO - Autism Res N2 - The increasing emphasis on translational approaches to complex neuropsychiatric and neurodevelopmental conditions research requires scientists from a broad range of disciplines to build dynamic collaborations when formulating hypotheses and framing study designs. The need to integrate the knowledge and perspectives not only from multiple scientific silos but also from the populations impacted by these conditions presents a significant challenge to researchers, particularly for a heterogeneous condition like autism. As one path toward addressing these challenges, we have previously introduced Autism Genetics Outcomes (AutGO), an initiative to support broad stakeholder partnerships and promote a new integrated concept called GO (i.e., research approaches that draw on both genetics and clinical outcomes perspectives). Herein, we developed a workflow for collecting stakeholders' feedback toward the development of a GO hypothesis. AutGO is an evolving initiative, and here we describe how its three essential components (conceptual framework, applicability, and implementation) have been developed. As a proof-of-concept, the AutGO team sought to demonstrate how a GO hypothesis could be developed using a semi-structured literature review workflow. We also developed a prototype from published reports and formulated a GO hypothesis for autism. Rather than seeking community stakeholder input after a research project is conceptualized and designed, the developed conceptual framework demonstrates the feasibility of formulating scientific hypotheses by engaging stakeholders in retrospective semi-structured literature reviews. The presented workflow, prototype, and discussed recommendations will bring awareness in the autism research community about the benefits of applying the GO approach in order to promote translational aspects in genetics research. LAY SUMMARY: We used a community-based engagement approach to develop AutGO (Autism Genetics Outcomes), an initiative to establish stakeholder partnerships and to promote research approaches (we refer to as GO) that draw on both genetics and clinical outcomes perspectives. Specifically, we developed a conceptual framework that includes a literature review process for developing GO hypotheses and stakeholder feedback collection protocol. Our work will bring awareness in the autism research community about the benefits of integrating patient perspectives in genetics research. SN - 1939-3806 UR - https://www.unboundmedicine.com/medline/citation/32618145/The_AutGO_Initiative:_A_Conceptual_Framework_for_Developing_Genetics-Outcomes_Research_Hypotheses L2 - https://doi.org/10.1002/aur.2331 DB - PRIME DP - Unbound Medicine ER -
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