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Perinatal maternal undernutrition does not result in offspring capillary rarefaction in the middle-aged male baboon at rest.
J Dev Orig Health Dis. 2020 Jun 19 [Online ahead of print]JD

Abstract

Microvascular health is a main determinant of coronary blood flow reserve and myocardial vascular resistance. Extracardiac capillary abnormality has been reported in subjects at increased coronary heart disease risk, such as prehypertension, hypertension, diabetes, hyperlipidemia, and atherosclerosis. We have reported cardiovascular dysfunction in a cohort of maternal nutrient reduction (MNR)-induced intrauterine growth restriction (IUGR) baboon offspring. Here we test the hypothesis that there is oral capillary rarefaction associated with MNR-induced IUGR. Capillary density was quantified using in vivo high-power capillaroscopy on seven middle-aged (~10.7 yr; human equivalent ~40 yr) male IUGR baboons and seven male age-matched controls in the lateral buccal and inferior labial mucosa. While no difference was found between groups in either area by fraction area or optical density for these vascular beds derived from fetal preductal vessels, further studies are needed on post-ductal vascular beds, retina, and function.

Authors+Show Affiliations

Department of Radiology and Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.Department of Animal Science, University of Wyoming, Laramie, WY, USA. Southwest National Primate Research Center, San Antonio, TX, USA.Department of Animal Science, University of Wyoming, Laramie, WY, USA.Department of Animal Science, University of Wyoming, Laramie, WY, USA. Southwest National Primate Research Center, San Antonio, TX, USA.Department of Radiology and Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. Southwest National Primate Research Center, San Antonio, TX, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32618548

Citation

Kuo, Anderson H., et al. "Perinatal Maternal Undernutrition Does Not Result in Offspring Capillary Rarefaction in the Middle-aged Male Baboon at Rest." Journal of Developmental Origins of Health and Disease, 2020, pp. 1-5.
Kuo AH, Li C, Huber HF, et al. Perinatal maternal undernutrition does not result in offspring capillary rarefaction in the middle-aged male baboon at rest. J Dev Orig Health Dis. 2020.
Kuo, A. H., Li, C., Huber, H. F., Nathanielsz, P. W., & Clarke, G. D. (2020). Perinatal maternal undernutrition does not result in offspring capillary rarefaction in the middle-aged male baboon at rest. Journal of Developmental Origins of Health and Disease, 1-5. https://doi.org/10.1017/S2040174420000550
Kuo AH, et al. Perinatal Maternal Undernutrition Does Not Result in Offspring Capillary Rarefaction in the Middle-aged Male Baboon at Rest. J Dev Orig Health Dis. 2020 Jun 19;1-5. PubMed PMID: 32618548.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Perinatal maternal undernutrition does not result in offspring capillary rarefaction in the middle-aged male baboon at rest. AU - Kuo,Anderson H, AU - Li,Cun, AU - Huber,Hillary F, AU - Nathanielsz,Peter W, AU - Clarke,Geoffrey D, Y1 - 2020/06/19/ PY - 2020/7/4/entrez PY - 2020/7/4/pubmed PY - 2020/7/4/medline KW - Maternal nutrient reduction KW - baboons KW - capillary density KW - developmental programming KW - intrauterine growth restriction (IUGR) SP - 1 EP - 5 JF - Journal of developmental origins of health and disease JO - J Dev Orig Health Dis N2 - Microvascular health is a main determinant of coronary blood flow reserve and myocardial vascular resistance. Extracardiac capillary abnormality has been reported in subjects at increased coronary heart disease risk, such as prehypertension, hypertension, diabetes, hyperlipidemia, and atherosclerosis. We have reported cardiovascular dysfunction in a cohort of maternal nutrient reduction (MNR)-induced intrauterine growth restriction (IUGR) baboon offspring. Here we test the hypothesis that there is oral capillary rarefaction associated with MNR-induced IUGR. Capillary density was quantified using in vivo high-power capillaroscopy on seven middle-aged (~10.7 yr; human equivalent ~40 yr) male IUGR baboons and seven male age-matched controls in the lateral buccal and inferior labial mucosa. While no difference was found between groups in either area by fraction area or optical density for these vascular beds derived from fetal preductal vessels, further studies are needed on post-ductal vascular beds, retina, and function. SN - 2040-1752 UR - https://www.unboundmedicine.com/medline/citation/32618548/Perinatal_maternal_undernutrition_does_not_result_in_offspring_capillary_rarefaction_in_the_middle-aged_male_baboon_at_rest L2 - https://www.cambridge.org/core/product/identifier/S2040174420000550/type/journal_article DB - PRIME DP - Unbound Medicine ER -
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