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Water, lithium and sodium: watch out for dangerous injuries.
Ann Biol Clin (Paris). 2020 Aug 01; 78(4):449-453.AB

Abstract

Nephrogenic diabetes insipidus due to the inability of the kidneys to concentrate urine is frequently observed during lithium therapy. Lithium concentrates into principal cells in collecting ducts in the kidney and downregulates aquaporin 2 expression, which reduces renal reabsorption of water. This disease is characterized by polyuria - polydipsia leading to intracellular dehydration and hypernatremia. Water deprivation test is performed to confirm insipidus diabetes. The desmopressin permits to distinguish nephrogenic from cranial insipidus diabetes. We report the case of a 64 years old women who presented with global dehydration and severe hypernatremia. Four years ago, she was hospitalized for nephrogenic diabetes insipidus related to a self-induced lithium intoxication. Persistent nephrogenic insipidus diabetes after cessation of lithium therapy are described in literature, and this hypothesis may be consistent with this case report.

Authors+Show Affiliations

Laboratoire de biochimie, Hôpital Lapeyronie, CHU Montpellier, France.Laboratoire de biochimie, Hôpital Lapeyronie, CHU Montpellier, France, Phymedexp, Université de Montpellier, Inserm, CNRS, CHU de Montpellier, Montpellier, France.Laboratoire de pharmacologie médicale et toxicologie, Hôpital Lapeyronie, CHU Montpellier, France.Laboratoire de biochimie, Hôpital Lapeyronie, CHU Montpellier, France, Phymedexp, Université de Montpellier, Inserm, CNRS, CHU de Montpellier, Montpellier, France.Laboratoire de biochimie, Hôpital Lapeyronie, CHU Montpellier, France, Phymedexp, Université de Montpellier, Inserm, CNRS, CHU de Montpellier, Montpellier, France.Laboratoire de biochimie, Hôpital Lapeyronie, CHU Montpellier, France, Phymedexp, Université de Montpellier, Inserm, CNRS, CHU de Montpellier, Montpellier, France.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32618565

Citation

Fayolle, Martin, et al. "Water, Lithium and Sodium: Watch Out for Dangerous Injuries." Annales De Biologie Clinique, vol. 78, no. 4, 2020, pp. 449-453.
Fayolle M, Souweine JS, Mathieu O, et al. Water, lithium and sodium: watch out for dangerous injuries. Ann Biol Clin (Paris). 2020;78(4):449-453.
Fayolle, M., Souweine, J. S., Mathieu, O., Bargnoux, A. S., Cristol, J. P., & Badiou, S. (2020). Water, lithium and sodium: watch out for dangerous injuries. Annales De Biologie Clinique, 78(4), 449-453. https://doi.org/10.1684/abc.2020.1570
Fayolle M, et al. Water, Lithium and Sodium: Watch Out for Dangerous Injuries. Ann Biol Clin (Paris). 2020 Aug 1;78(4):449-453. PubMed PMID: 32618565.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Water, lithium and sodium: watch out for dangerous injuries. AU - Fayolle,Martin, AU - Souweine,Jean-Sébastien, AU - Mathieu,Olivier, AU - Bargnoux,Anne-Sophie, AU - Cristol,Jean-Paul, AU - Badiou,Stéphanie, PY - 2020/7/4/pubmed PY - 2020/7/4/medline PY - 2020/7/4/entrez KW - diuretic KW - hypernatremia KW - lithium KW - nephrogenic diabetes insipidus SP - 449 EP - 453 JF - Annales de biologie clinique JO - Ann. Biol. Clin. (Paris) VL - 78 IS - 4 N2 - Nephrogenic diabetes insipidus due to the inability of the kidneys to concentrate urine is frequently observed during lithium therapy. Lithium concentrates into principal cells in collecting ducts in the kidney and downregulates aquaporin 2 expression, which reduces renal reabsorption of water. This disease is characterized by polyuria - polydipsia leading to intracellular dehydration and hypernatremia. Water deprivation test is performed to confirm insipidus diabetes. The desmopressin permits to distinguish nephrogenic from cranial insipidus diabetes. We report the case of a 64 years old women who presented with global dehydration and severe hypernatremia. Four years ago, she was hospitalized for nephrogenic diabetes insipidus related to a self-induced lithium intoxication. Persistent nephrogenic insipidus diabetes after cessation of lithium therapy are described in literature, and this hypothesis may be consistent with this case report. SN - 1950-6112 UR - https://www.unboundmedicine.com/medline/citation/32618565/Water,_lithium_and_sodium:_watch_out_for_dangerous_injuries L2 - http://www.john-libbey-eurotext.fr/medline.md?doi=10.1684/abc.2020.1570 DB - PRIME DP - Unbound Medicine ER -
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