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[Diagnostic utility of creatine kinase elevation in the routine biochemical profile in cats].
Schweiz Arch Tierheilkd. 2020 Jul; 162(7):451-462.SA

Abstract

INTRODUCTION

Creatine kinase (CK) is a muscle enzyme that is very sensitive to muscle damage. Therefore, serum CK is measured particularly to confirm suspected myopathy. Since 2013, this enzyme has been included in the routine chemistry profile in our hospital. Soon thereafter, the subjective impression developed that its elevation did not correlate to and was not explainable with the actual clinical problem. Therefore, the aim of this retrospective study was to investigate in which clinical cases the CK elevation was adequate and in which cases without clinical evidence of muscle damage the CK was so markedly elevated that it implied a clinically relevant muscle damage. For this purpose, we evaluated the CK values of 1641 cats presented in the years 2013/2014 at our university animal hospital. The CK was comprehensibly elevated in cats with trauma and various diseases with obvious and traceable muscle damage like thrombo-embolic damage or seizures. In addition, the CK was elevated in diseases where concomitant muscle damage is perceivable like in cats with hypertrophic cardiomyopathy. However, the CK also was commonly and sometimes dramatically elevated in cats of essentially any disease group without any comprehensible skeletal muscular lesion. These results confirm the hypothesis that the diagnostic value of this parameter is most questionable. A CK elevation does not allow any conclusion regarding its original diagnostic purpose, i.e. to confirm the presence of a clinically relevant myopathy.

Authors+Show Affiliations

Abteilung für Kardiologie, Klinik für Kleintiermedizin, Vetsuisse-Fakultät, Universität Zürich.Veterinärmedizinisches Labor, Vetsuisse-Fakultät, Universität Zürich.Veterinärmedizinisches Labor, Vetsuisse-Fakultät, Universität Zürich.Abteilung für Kardiologie, Klinik für Kleintiermedizin, Vetsuisse-Fakultät, Universität Zürich.Abteilung für Kardiologie, Klinik für Kleintiermedizin, Vetsuisse-Fakultät, Universität Zürich.

Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

32618568

Citation

Rusterholz, S, et al. "[Diagnostic Utility of Creatine Kinase Elevation in the Routine Biochemical Profile in Cats]." Schweizer Archiv Fur Tierheilkunde, vol. 162, no. 7, 2020, pp. 451-462.
Rusterholz S, Riond B, Stirn M, et al. [Diagnostic utility of creatine kinase elevation in the routine biochemical profile in cats]. Schweiz Arch Tierheilkd. 2020;162(7):451-462.
Rusterholz, S., Riond, B., Stirn, M., Ivasovic, F., & Glaus, T. (2020). [Diagnostic utility of creatine kinase elevation in the routine biochemical profile in cats]. Schweizer Archiv Fur Tierheilkunde, 162(7), 451-462. https://doi.org/10.17236/sat00266
Rusterholz S, et al. [Diagnostic Utility of Creatine Kinase Elevation in the Routine Biochemical Profile in Cats]. Schweiz Arch Tierheilkd. 2020;162(7):451-462. PubMed PMID: 32618568.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Diagnostic utility of creatine kinase elevation in the routine biochemical profile in cats]. AU - Rusterholz,S, AU - Riond,B, AU - Stirn,M, AU - Ivasovic,F, AU - Glaus,T, PY - 2020/7/4/entrez PY - 2020/7/4/pubmed PY - 2020/7/4/medline KW - Hyper-CK-ämie KW - Myopathie KW - glatte Muskulatur KW - hyper-CK-emia KW - hyper-CK-émie KW - maladie systémique KW - malattie sistemiche KW - miopatia KW - muscle lisse KW - myopathie KW - myopathy KW - smooth muscle KW - systemic disease KW - systemische Erkrankung KW - tessuto muscolare liscio SP - 451 EP - 462 JF - Schweizer Archiv fur Tierheilkunde JO - Schweiz. Arch. Tierheilkd. VL - 162 IS - 7 N2 - INTRODUCTION: Creatine kinase (CK) is a muscle enzyme that is very sensitive to muscle damage. Therefore, serum CK is measured particularly to confirm suspected myopathy. Since 2013, this enzyme has been included in the routine chemistry profile in our hospital. Soon thereafter, the subjective impression developed that its elevation did not correlate to and was not explainable with the actual clinical problem. Therefore, the aim of this retrospective study was to investigate in which clinical cases the CK elevation was adequate and in which cases without clinical evidence of muscle damage the CK was so markedly elevated that it implied a clinically relevant muscle damage. For this purpose, we evaluated the CK values of 1641 cats presented in the years 2013/2014 at our university animal hospital. The CK was comprehensibly elevated in cats with trauma and various diseases with obvious and traceable muscle damage like thrombo-embolic damage or seizures. In addition, the CK was elevated in diseases where concomitant muscle damage is perceivable like in cats with hypertrophic cardiomyopathy. However, the CK also was commonly and sometimes dramatically elevated in cats of essentially any disease group without any comprehensible skeletal muscular lesion. These results confirm the hypothesis that the diagnostic value of this parameter is most questionable. A CK elevation does not allow any conclusion regarding its original diagnostic purpose, i.e. to confirm the presence of a clinically relevant myopathy. SN - 1664-2848 UR - https://www.unboundmedicine.com/medline/citation/32618568/[Diagnostic_utility_of_creatine_kinase_elevation_in_the_routine_biochemical_profile_in_cats] L2 - https://sat.gstsvs.ch/de/pubmed/?doi=10.17236/sat00266 DB - PRIME DP - Unbound Medicine ER -
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