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Increased Risk of Colorectal Cancer Tied to Advanced Colorectal Polyps: An Untapped Opportunity to Screen First-Degree Relatives and Decrease Cancer Burden.
Am J Gastroenterol. 2020 Jul; 115(7):980-988.AJ

Abstract

Advanced adenomas represent a subset of colorectal polyps that are known to confer an increased risk of colorectal neoplasia to the affected individual and their first-degree relatives (FDRs). Accordingly, professional guidelines suggest earlier and more intensive screening for FDRs of those with advanced adenomas similar to FDRs of those with colorectal cancer (CRC). Although the risk to family members is less clear among patients with advanced serrated polyps, they are often considered in the same category. Unfortunately, there is a growing concern that patients, endoscopists, and primary care providers are unaware of the familial risk associated with these polyps, leaving a wide gap in screening these high-risk individuals. Herein, we propose a standardized language around advanced colorectal polyps and present a detailed review of the literature on associated familial risk. We outline the challenges to implementing the current screening recommendations and suggest approaches to overcome these limitations, including a proposed new colonoscopy quality metric to capture communication of familial CRC risk. Improving screening in these high-risk groups has the potential to substantially reduce the burden of CRC.

Authors+Show Affiliations

Division of Gastroenterology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.Department of Occupational, Medicine, Epidemiology, and Prevention, Center for Health Innovations and Outcomes Research, Feinstein Institute for Medical Research, Hofstra/Northwell School of Medicine, Northwell Health, Manhasset, New York, USA.Division of Gastroenterology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. Rocky Mountain Regional Veterans Affairs Medical Center, Aurora, Colorado, USA.Division of Gastroenterology and Hepatology, Oregon Health and Science University, Portland, Oregon, USA. Portland Veterans Affairs Medical Center, Portland, Oregon, USA.Division of Gastroenterology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32618646

Citation

Kolb, Jennifer M., et al. "Increased Risk of Colorectal Cancer Tied to Advanced Colorectal Polyps: an Untapped Opportunity to Screen First-Degree Relatives and Decrease Cancer Burden." The American Journal of Gastroenterology, vol. 115, no. 7, 2020, pp. 980-988.
Kolb JM, Molmenti CL, Patel SG, et al. Increased Risk of Colorectal Cancer Tied to Advanced Colorectal Polyps: An Untapped Opportunity to Screen First-Degree Relatives and Decrease Cancer Burden. Am J Gastroenterol. 2020;115(7):980-988.
Kolb, J. M., Molmenti, C. L., Patel, S. G., Lieberman, D. A., & Ahnen, D. J. (2020). Increased Risk of Colorectal Cancer Tied to Advanced Colorectal Polyps: An Untapped Opportunity to Screen First-Degree Relatives and Decrease Cancer Burden. The American Journal of Gastroenterology, 115(7), 980-988. https://doi.org/10.14309/ajg.0000000000000639
Kolb JM, et al. Increased Risk of Colorectal Cancer Tied to Advanced Colorectal Polyps: an Untapped Opportunity to Screen First-Degree Relatives and Decrease Cancer Burden. Am J Gastroenterol. 2020;115(7):980-988. PubMed PMID: 32618646.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased Risk of Colorectal Cancer Tied to Advanced Colorectal Polyps: An Untapped Opportunity to Screen First-Degree Relatives and Decrease Cancer Burden. AU - Kolb,Jennifer M, AU - Molmenti,Christine L, AU - Patel,Swati G, AU - Lieberman,David A, AU - Ahnen,Dennis J, PY - 2020/7/4/entrez PY - 2020/7/4/pubmed PY - 2020/7/4/medline SP - 980 EP - 988 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 115 IS - 7 N2 - Advanced adenomas represent a subset of colorectal polyps that are known to confer an increased risk of colorectal neoplasia to the affected individual and their first-degree relatives (FDRs). Accordingly, professional guidelines suggest earlier and more intensive screening for FDRs of those with advanced adenomas similar to FDRs of those with colorectal cancer (CRC). Although the risk to family members is less clear among patients with advanced serrated polyps, they are often considered in the same category. Unfortunately, there is a growing concern that patients, endoscopists, and primary care providers are unaware of the familial risk associated with these polyps, leaving a wide gap in screening these high-risk individuals. Herein, we propose a standardized language around advanced colorectal polyps and present a detailed review of the literature on associated familial risk. We outline the challenges to implementing the current screening recommendations and suggest approaches to overcome these limitations, including a proposed new colonoscopy quality metric to capture communication of familial CRC risk. Improving screening in these high-risk groups has the potential to substantially reduce the burden of CRC. SN - 1572-0241 UR - https://www.unboundmedicine.com/medline/citation/32618646/Increased_Risk_of_Colorectal_Cancer_Tied_to_Advanced_Colorectal_Polyps:_An_Untapped_Opportunity_to_Screen_First-Degree_Relatives_and_Decrease_Cancer_Burden L2 - https://Insights.ovid.com/pubmed?pmid=32618646 DB - PRIME DP - Unbound Medicine ER -
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