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Appetite control: hormones or diet strategies?
Curr Opin Clin Nutr Metab Care. 2020 Jun 28 [Online ahead of print]CO

Abstract

PURPOSE OF REVIEW

Appetite control results from metabolic, behavioral, and environmental factors that influence hunger and the desire to eat. We summarize the latest advances in the hormonal and nutritional strategies to control appetite and reduce hunger.

RECENT FINDINGS

The fed-hunger-state is regulated by central and peripheric hormones, which modulate energy balance. Leptin, insulin, ghrelin, peptide YY (PYY), and other gut-derived peptides represent the main appetite controllers. The role of orexins, obestatin, and liver-expressed antimicrobial peptide 2 has been uncovered recently. New insights have demonstrated the role of hippocampal activity as a possible mechanism of action. Glucagon-like peptide 1 (GLP1) receptor agonists are well known agents controlling appetite. Association of GLP1 receptor agonist, PYY, or glucose-dependent insulinotropic polypeptide agonists have been tested as new approaches. Appetite-control hormones have also risen as factors involved in the efficacy of bariatric procedures. High-protein, ketogenic diet, and intermittent fasting have been described as nutritional strategies to reduce appetite, although the physiological mechanism and long-term safety remains unclear.

SUMMARY

Appetite control has been an important target for the treatment of obesity and associated disorders. New studies have demonstrated promising adoption of dietary approaches, hormone-based drugs, and bariatric surgery to control energy intake. Further research will establish a significant association, benefits, and safety of these new therapies.

Authors+Show Affiliations

Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32618724

Citation

Freire, Rachel H., and Jacqueline I. Alvarez-Leite. "Appetite Control: Hormones or Diet Strategies?" Current Opinion in Clinical Nutrition and Metabolic Care, 2020.
Freire RH, Alvarez-Leite JI. Appetite control: hormones or diet strategies? Curr Opin Clin Nutr Metab Care. 2020.
Freire, R. H., & Alvarez-Leite, J. I. (2020). Appetite control: hormones or diet strategies? Current Opinion in Clinical Nutrition and Metabolic Care. https://doi.org/10.1097/MCO.0000000000000675
Freire RH, Alvarez-Leite JI. Appetite Control: Hormones or Diet Strategies. Curr Opin Clin Nutr Metab Care. 2020 Jun 28; PubMed PMID: 32618724.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Appetite control: hormones or diet strategies? AU - Freire,Rachel H, AU - Alvarez-Leite,Jacqueline I, Y1 - 2020/06/28/ PY - 2020/7/4/entrez JF - Current opinion in clinical nutrition and metabolic care JO - Curr Opin Clin Nutr Metab Care N2 - PURPOSE OF REVIEW: Appetite control results from metabolic, behavioral, and environmental factors that influence hunger and the desire to eat. We summarize the latest advances in the hormonal and nutritional strategies to control appetite and reduce hunger. RECENT FINDINGS: The fed-hunger-state is regulated by central and peripheric hormones, which modulate energy balance. Leptin, insulin, ghrelin, peptide YY (PYY), and other gut-derived peptides represent the main appetite controllers. The role of orexins, obestatin, and liver-expressed antimicrobial peptide 2 has been uncovered recently. New insights have demonstrated the role of hippocampal activity as a possible mechanism of action. Glucagon-like peptide 1 (GLP1) receptor agonists are well known agents controlling appetite. Association of GLP1 receptor agonist, PYY, or glucose-dependent insulinotropic polypeptide agonists have been tested as new approaches. Appetite-control hormones have also risen as factors involved in the efficacy of bariatric procedures. High-protein, ketogenic diet, and intermittent fasting have been described as nutritional strategies to reduce appetite, although the physiological mechanism and long-term safety remains unclear. SUMMARY: Appetite control has been an important target for the treatment of obesity and associated disorders. New studies have demonstrated promising adoption of dietary approaches, hormone-based drugs, and bariatric surgery to control energy intake. Further research will establish a significant association, benefits, and safety of these new therapies. SN - 1473-6519 UR - https://www.unboundmedicine.com/medline/citation/32618724/Appetite_control:_hormones_or_diet_strategies L2 - https://doi.org/10.1097/MCO.0000000000000675 DB - PRIME DP - Unbound Medicine ER -
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