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Trends in pediatric skin cancer.
Curr Opin Pediatr. 2020 Aug; 32(4):516-523.CO

Abstract

PURPOSE OF REVIEW

To inform pediatric providers of the clinical characteristics, underlying genetic drivers, and therapeutic options for skin cancer arising in childhood and adolescence.

RECENT FINDINGS

The incidence of melanoma in pediatric patients has been declining in the past decades. Pediatric-specific diagnostic criteria should be utilized when assessing lesions concerning for melanoma to better account for the different presentations seen in pediatric disease compared with adults, such as an increased prevalence of amelanotic melanoma or frequent mimic of benign pediatric lesions. Pediatric melanoma often presents with a higher histopathologic stage and a higher Breslow depth as compared with adult melanoma. Pediatric nonmelanoma skin cancer including basal cell carcinoma and squamous cell carcinoma are associated with genetic conditions and immunosuppression, both iatrogenic and inherited.

SUMMARY

Melanoma in pediatric patients often presents differently from conventional adult melanoma, including Spitz melanoma and melanoma associated with congenital melanocytic nevi. Pediatric patients with nonmelanoma skin cancers should be evaluated for predisposing risk factors. More research on therapeutic options for pediatric skin cancer is vital to understanding the tolerance and response of our pediatric patients to therapies that are more frequently utilized in adult disease.

Authors+Show Affiliations

aHarvard Medical School, Boston, Massachusetts, USA bDepartment of Dermatology, Massachusetts General Hospital, Boston, Massachusetts, USA cUniversity of Massachusetts School of Medicine, Worcester, Massachusetts, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32618791

Citation

Moustafa, Danna, et al. "Trends in Pediatric Skin Cancer." Current Opinion in Pediatrics, vol. 32, no. 4, 2020, pp. 516-523.
Moustafa D, Neale H, Hawryluk EB. Trends in pediatric skin cancer. Curr Opin Pediatr. 2020;32(4):516-523.
Moustafa, D., Neale, H., & Hawryluk, E. B. (2020). Trends in pediatric skin cancer. Current Opinion in Pediatrics, 32(4), 516-523. https://doi.org/10.1097/MOP.0000000000000917
Moustafa D, Neale H, Hawryluk EB. Trends in Pediatric Skin Cancer. Curr Opin Pediatr. 2020;32(4):516-523. PubMed PMID: 32618791.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Trends in pediatric skin cancer. AU - Moustafa,Danna, AU - Neale,Holly, AU - Hawryluk,Elena B, PY - 2020/7/4/pubmed PY - 2020/7/4/medline PY - 2020/7/4/entrez SP - 516 EP - 523 JF - Current opinion in pediatrics JO - Curr. Opin. Pediatr. VL - 32 IS - 4 N2 - PURPOSE OF REVIEW: To inform pediatric providers of the clinical characteristics, underlying genetic drivers, and therapeutic options for skin cancer arising in childhood and adolescence. RECENT FINDINGS: The incidence of melanoma in pediatric patients has been declining in the past decades. Pediatric-specific diagnostic criteria should be utilized when assessing lesions concerning for melanoma to better account for the different presentations seen in pediatric disease compared with adults, such as an increased prevalence of amelanotic melanoma or frequent mimic of benign pediatric lesions. Pediatric melanoma often presents with a higher histopathologic stage and a higher Breslow depth as compared with adult melanoma. Pediatric nonmelanoma skin cancer including basal cell carcinoma and squamous cell carcinoma are associated with genetic conditions and immunosuppression, both iatrogenic and inherited. SUMMARY: Melanoma in pediatric patients often presents differently from conventional adult melanoma, including Spitz melanoma and melanoma associated with congenital melanocytic nevi. Pediatric patients with nonmelanoma skin cancers should be evaluated for predisposing risk factors. More research on therapeutic options for pediatric skin cancer is vital to understanding the tolerance and response of our pediatric patients to therapies that are more frequently utilized in adult disease. SN - 1531-698X UR - https://www.unboundmedicine.com/medline/citation/32618791/Trends_in_pediatric_skin_cancer L2 - https://doi.org/10.1097/MOP.0000000000000917 DB - PRIME DP - Unbound Medicine ER -
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