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A speckle tracking echocardiographic study on right ventricular function in primary aldosteronism.
J Hypertens. 2020 Jun 25 [Online ahead of print]JH

Abstract

OBJECTIVE

We investigated right ventricular function using speckle tracking echocardiography (STE) in patients with primary aldosteronism.

METHODS

Our study included 51 primary aldosteronism patients and 50 age and sex-matched primary hypertensive patients. We performed two-dimensional echocardiography to measure cardiac structure and function. We performed STE offline analysis on right ventricular four-chamber (RV4CLS) and free wall longitudinal strains (RVFWLS).

RESULTS

Primary aldosteronism patients, compared with primary hypertensive patients, had a significantly (P ≤ 0.045) greater left ventricular mass index (112.0 ± 22.6 vs. 95.8 ± 18.5 g/m) and left atrial volume index (26.9 ± 6.0 vs. 24.7 ± 5.6 ml/m) and higher prevalence of left ventricular concentric hypertrophy (35.3 vs. 12.0%), although they had similarly normal left ventricular ejection fraction (55-77%). Primary aldosteronism patients also had a significantly (P ≤ 0.047) larger right atrium and ventricle, lower tricuspid annular plane systolic excursion, and higher E/E't (the peak early filling velocity of trans-tricuspid flow to the peak early filling velocity of lateral tricuspid annulus ratio), estimated pulmonary arterial systolic pressure and right ventricular index of myocardial performance. On the right ventricular strain analysis, primary aldosteronism patients had a significantly (P < 0.001) lower RV4CLS (-18.1 ± 2.5 vs. -23.3 ± 3.4%) and RVFWLS (-21.7 ± 3.7 vs. -27.9 ± 4.5%) than primary hypertensive patients. Overall, RV4CLS and RVFWLS were significantly (r = -0.58 to -0.41, P < 0.001) correlated with plasma aldosterone concentration and 24-h urinary aldosterone excretion. After adjustment for confounding factors, the associations for RV4CLS and RVFWLS with 24-h urinary aldosterone excretion remained significant (P < 0.001), with a standardized coefficient of -0.48 and -0.55, respectively.

CONCLUSION

In addition to left ventricular abnormalities, primary aldosteronism patients also show impaired right ventricular function, probably because of hyperaldosteronism.

Authors+Show Affiliations

Centre for Cardiovascular Evaluations, The Shanghai Institute of Hypertension, Department of Hypertension, Shanghai Key Lab of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. Yi-Lin Chen and Ting-Yan Xu are cofirst authors.Centre for Cardiovascular Evaluations, The Shanghai Institute of Hypertension, Department of Hypertension, Shanghai Key Lab of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. Yi-Lin Chen and Ting-Yan Xu are cofirst authors.Centre for Cardiovascular Evaluations, The Shanghai Institute of Hypertension, Department of Hypertension, Shanghai Key Lab of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.Centre for Cardiovascular Evaluations, The Shanghai Institute of Hypertension, Department of Hypertension, Shanghai Key Lab of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.Centre for Cardiovascular Evaluations, The Shanghai Institute of Hypertension, Department of Hypertension, Shanghai Key Lab of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.Centre for Cardiovascular Evaluations, The Shanghai Institute of Hypertension, Department of Hypertension, Shanghai Key Lab of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32618893

Citation

Chen, Yi-Lin, et al. "A Speckle Tracking Echocardiographic Study On Right Ventricular Function in Primary Aldosteronism." Journal of Hypertension, 2020.
Chen YL, Xu TY, Xu JZ, et al. A speckle tracking echocardiographic study on right ventricular function in primary aldosteronism. J Hypertens. 2020.
Chen, Y. L., Xu, T. Y., Xu, J. Z., Zhu, L. M., Li, Y., & Wang, J. G. (2020). A speckle tracking echocardiographic study on right ventricular function in primary aldosteronism. Journal of Hypertension. https://doi.org/10.1097/HJH.0000000000002527
Chen YL, et al. A Speckle Tracking Echocardiographic Study On Right Ventricular Function in Primary Aldosteronism. J Hypertens. 2020 Jun 25; PubMed PMID: 32618893.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A speckle tracking echocardiographic study on right ventricular function in primary aldosteronism. AU - Chen,Yi-Lin, AU - Xu,Ting-Yan, AU - Xu,Jian-Zhong, AU - Zhu,Li-Min, AU - Li,Yan, AU - Wang,Ji-Guang, Y1 - 2020/06/25/ PY - 2020/7/4/entrez JF - Journal of hypertension JO - J. Hypertens. N2 - OBJECTIVE: We investigated right ventricular function using speckle tracking echocardiography (STE) in patients with primary aldosteronism. METHODS: Our study included 51 primary aldosteronism patients and 50 age and sex-matched primary hypertensive patients. We performed two-dimensional echocardiography to measure cardiac structure and function. We performed STE offline analysis on right ventricular four-chamber (RV4CLS) and free wall longitudinal strains (RVFWLS). RESULTS: Primary aldosteronism patients, compared with primary hypertensive patients, had a significantly (P ≤ 0.045) greater left ventricular mass index (112.0 ± 22.6 vs. 95.8 ± 18.5 g/m) and left atrial volume index (26.9 ± 6.0 vs. 24.7 ± 5.6 ml/m) and higher prevalence of left ventricular concentric hypertrophy (35.3 vs. 12.0%), although they had similarly normal left ventricular ejection fraction (55-77%). Primary aldosteronism patients also had a significantly (P ≤ 0.047) larger right atrium and ventricle, lower tricuspid annular plane systolic excursion, and higher E/E't (the peak early filling velocity of trans-tricuspid flow to the peak early filling velocity of lateral tricuspid annulus ratio), estimated pulmonary arterial systolic pressure and right ventricular index of myocardial performance. On the right ventricular strain analysis, primary aldosteronism patients had a significantly (P < 0.001) lower RV4CLS (-18.1 ± 2.5 vs. -23.3 ± 3.4%) and RVFWLS (-21.7 ± 3.7 vs. -27.9 ± 4.5%) than primary hypertensive patients. Overall, RV4CLS and RVFWLS were significantly (r = -0.58 to -0.41, P < 0.001) correlated with plasma aldosterone concentration and 24-h urinary aldosterone excretion. After adjustment for confounding factors, the associations for RV4CLS and RVFWLS with 24-h urinary aldosterone excretion remained significant (P < 0.001), with a standardized coefficient of -0.48 and -0.55, respectively. CONCLUSION: In addition to left ventricular abnormalities, primary aldosteronism patients also show impaired right ventricular function, probably because of hyperaldosteronism. SN - 1473-5598 UR - https://www.unboundmedicine.com/medline/citation/32618893/A_speckle_tracking_echocardiographic_study_on_right_ventricular_function_in_primary_aldosteronism L2 - https://doi.org/10.1097/HJH.0000000000002527 DB - PRIME DP - Unbound Medicine ER -
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