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Characterization of holmium(iii)-acetylacetonate complexes derived from therapeutic microspheres by infrared ion spectroscopy.
Phys Chem Chem Phys. 2020 Jul 21; 22(27):15716-15722.PC

Abstract

Microspheres containing radioactive 166holmium-acetylacetonate are employed in emerging radionuclide therapies for the treatment of malignancies. At the molecular level, details on the coordination geometries of the Ho complexes are however elusive. Infrared ion spectroscopy (IRIS) was used to characterize several 165Ho-acetylacetonate complexes derived from non-radioactive microspheres. The coordination geometry of four distinct ionic complexes were fully assigned by comparison of their measured IR spectra with spectra calculated at the density functional theory (DFT) level. The coordination of each acetylacetonate ligand is dependent on the presence of other ligands, revealing an asymmetric chelation motif in some of the complexes. A fifth, previously unknown constituent of the microspheres was identified as a coordination complex containing an acetic acid ligand. These results pave the way for IRIS-based identification of microsphere constituents upon neutron activation of the metal center.

Authors+Show Affiliations

Radboud University, Institute for Molecules and Materials, FELIX Laboratory, Toernooiveld 7, 6525ED Nijmegen, The Netherlands. jonathan.martens@ru.nl j.oomens@science.ru.nl.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32618970

Citation

Houthuijs, Kas J., et al. "Characterization of Holmium(iii)-acetylacetonate Complexes Derived From Therapeutic Microspheres By Infrared Ion Spectroscopy." Physical Chemistry Chemical Physics : PCCP, vol. 22, no. 27, 2020, pp. 15716-15722.
Houthuijs KJ, Martens J, Arranja AG, et al. Characterization of holmium(iii)-acetylacetonate complexes derived from therapeutic microspheres by infrared ion spectroscopy. Phys Chem Chem Phys. 2020;22(27):15716-15722.
Houthuijs, K. J., Martens, J., Arranja, A. G., Berden, G., Nijsen, J. F. W., & Oomens, J. (2020). Characterization of holmium(iii)-acetylacetonate complexes derived from therapeutic microspheres by infrared ion spectroscopy. Physical Chemistry Chemical Physics : PCCP, 22(27), 15716-15722. https://doi.org/10.1039/d0cp01890b
Houthuijs KJ, et al. Characterization of Holmium(iii)-acetylacetonate Complexes Derived From Therapeutic Microspheres By Infrared Ion Spectroscopy. Phys Chem Chem Phys. 2020 Jul 21;22(27):15716-15722. PubMed PMID: 32618970.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characterization of holmium(iii)-acetylacetonate complexes derived from therapeutic microspheres by infrared ion spectroscopy. AU - Houthuijs,Kas J, AU - Martens,Jonathan, AU - Arranja,Alexandra G, AU - Berden,Giel, AU - Nijsen,J Frank W, AU - Oomens,Jos, Y1 - 2020/07/03/ PY - 2020/7/4/pubmed PY - 2020/7/4/medline PY - 2020/7/4/entrez SP - 15716 EP - 15722 JF - Physical chemistry chemical physics : PCCP JO - Phys Chem Chem Phys VL - 22 IS - 27 N2 - Microspheres containing radioactive 166holmium-acetylacetonate are employed in emerging radionuclide therapies for the treatment of malignancies. At the molecular level, details on the coordination geometries of the Ho complexes are however elusive. Infrared ion spectroscopy (IRIS) was used to characterize several 165Ho-acetylacetonate complexes derived from non-radioactive microspheres. The coordination geometry of four distinct ionic complexes were fully assigned by comparison of their measured IR spectra with spectra calculated at the density functional theory (DFT) level. The coordination of each acetylacetonate ligand is dependent on the presence of other ligands, revealing an asymmetric chelation motif in some of the complexes. A fifth, previously unknown constituent of the microspheres was identified as a coordination complex containing an acetic acid ligand. These results pave the way for IRIS-based identification of microsphere constituents upon neutron activation of the metal center. SN - 1463-9084 UR - https://www.unboundmedicine.com/medline/citation/32618970/Characterization_of_holmium(iii)-acetylacetonate_complexes_derived_from_therapeutic_microspheres_by_infrared_ion_spectroscopy L2 - https://doi.org/10.1039/d0cp01890b DB - PRIME DP - Unbound Medicine ER -
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