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Pharmacological treatment strategies for patients with monogenic obesity.
J Pediatr Endocrinol Metab. 2020 Jul 03 [Online ahead of print]JP

Abstract

The leptin melanocortin signaling pathway is playing a pivotal role for body weight regulation. Genetic defects within this cascade are leading to severe hyperphagia and early onset obesity. In most cases, due to persistent hyperphagia the affected patients are not able to stabilize body weight for a longer period of time with conservative treatment strategies based on lifestyle interventions. Therefore, it is of importance to implement alternative treatment options for these patients. This review provides an overview about the published pharmacological treatment attempts in respect to monogenic forms of obesity and summarizes recent research progress about the role of MC4R signaling and POMC derivatives for body weight regulation.

Authors+Show Affiliations

Institute for Experimental Pediatric Endocrinology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany. Berlin Institute of Health, Augustenburger Platz 1, 13353 Berlin, Germany.Berlin Institute of Health, Augustenburger Platz 1, 13353 Berlin, Germany. Center for Social-Pediatric Care, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.Institute for Experimental Pediatric Endocrinology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany. Berlin Institute of Health, Augustenburger Platz 1, 13353 Berlin, Germany.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32619193

Citation

Kühnen, Peter, et al. "Pharmacological Treatment Strategies for Patients With Monogenic Obesity." Journal of Pediatric Endocrinology & Metabolism : JPEM, 2020.
Kühnen P, Wiegand S, Biebermann H. Pharmacological treatment strategies for patients with monogenic obesity. J Pediatr Endocrinol Metab. 2020.
Kühnen, P., Wiegand, S., & Biebermann, H. (2020). Pharmacological treatment strategies for patients with monogenic obesity. Journal of Pediatric Endocrinology & Metabolism : JPEM. https://doi.org/10.1515/jpem-2020-0129
Kühnen P, Wiegand S, Biebermann H. Pharmacological Treatment Strategies for Patients With Monogenic Obesity. J Pediatr Endocrinol Metab. 2020 Jul 3; PubMed PMID: 32619193.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacological treatment strategies for patients with monogenic obesity. AU - Kühnen,Peter, AU - Wiegand,Susanna, AU - Biebermann,Heike, Y1 - 2020/07/03/ PY - 2020/03/20/received PY - 2020/04/04/accepted PY - 2020/7/4/entrez PY - 2020/7/4/pubmed PY - 2020/7/4/medline KW - MC4R KW - MC4R agonist KW - POMC KW - biased signaling KW - monogenic obesity JF - Journal of pediatric endocrinology & metabolism : JPEM JO - J. Pediatr. Endocrinol. Metab. N2 - The leptin melanocortin signaling pathway is playing a pivotal role for body weight regulation. Genetic defects within this cascade are leading to severe hyperphagia and early onset obesity. In most cases, due to persistent hyperphagia the affected patients are not able to stabilize body weight for a longer period of time with conservative treatment strategies based on lifestyle interventions. Therefore, it is of importance to implement alternative treatment options for these patients. This review provides an overview about the published pharmacological treatment attempts in respect to monogenic forms of obesity and summarizes recent research progress about the role of MC4R signaling and POMC derivatives for body weight regulation. SN - 2191-0251 UR - https://www.unboundmedicine.com/medline/citation/32619193/Pharmacological_treatment_strategies_for_patients_with_monogenic_obesity L2 - https://www.degruyter.com/doi/10.1515/jpem-2020-0129 DB - PRIME DP - Unbound Medicine ER -
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