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GABAergic and glutamatergic effects on nigrostriatal and mesolimbic dopamine release in the rat.
Rev Neurosci. 2020 Jul 03 [Online ahead of print]RN

Abstract

In this review, a series of experiments is presented, in which γ-amino butyric acid (GABA)ergic and glutamatergic effects on dopamine function in the rat nigrostriatal and mesolimbic system was systematically assessed after pharmacological challenge with GABAA receptor (R) and and N-methyl d-aspartate (NMDA)R agonists and antagonists. In these studies, [123I]iodobenzamide binding to the D2/3R was mesured in nucleus accumbens (NAC), caudateputamen (CP), substantia nigra/ventral tegmental area (SN/VTA), frontal (FC), motor (MC) and parietal cortex (PC) as well as anterior (aHIPP) and posterior hippocampus (pHIPP) with small animal SPECT in baseline and after injection of either the GABAAR agonist muscimol (1 mg/kg), the GABAAR antagonist bicuculline (1 mg/kg), the NMDAR agonist d-cycloserine (20 mg/kg) or the NMDAR antagonist amantadine (40 mg/kg). Muscimol reduced D2/3R binding in NAC, CP, SN/VTA, THAL and pHIPP, while, after amantadine, decreases were confined to NAC, CP and THAL. In contrast, d-cycloserine elevated D2/3R binding in NAC, SN/VTA, THAL, frontal cortex, motor cortex, PC, aHIPP and pHIPP, while, after bicuculline, increases were confined to CP and THAL. Taken together, similar actions on regional dopamine levels were exterted by the GABAAR agonist and the NMDAR antagonist on the one side and by the GABAAR antagonist and the NMDAR agonist on the other, with agonistic action, however, affecting more brain regions. Thereby, network analysis suggests different roles of GABAARs and NMDARs in the mediation of nigrostriatal, nigrothalamocortical and mesolimbocortical dopamine function.

Authors+Show Affiliations

Clinic of Nuclear Medicine, University Hospital Düsseldorf, Moorenstr. 5, D-40225, Düsseldorf, Germany.Clinic of Nuclear Medicine, University Hospital Düsseldorf, Moorenstr. 5, D-40225, Düsseldorf, Germany.Department of Diagnostic and Interventional Radiology, University Hospital Düsseldorf, Moorenstr. 5, D-40225, Düsseldorf, Germany.Department of Diagnostic and Interventional Radiology, University Hospital Düsseldorf, Moorenstr. 5, D-40225, Düsseldorf, Germany.Clinic of Nuclear Medicine, University Hospital Düsseldorf, Moorenstr. 5, D-40225, Düsseldorf, Germany.Clinic for Nuclear Medicine, University Hospital Essen, Hufelandstraβe 55, D-40225, Essen, Germany.Clinic of Nuclear Medicine, University Hospital Düsseldorf, Moorenstr. 5, D-40225, Düsseldorf, Germany.Clinic of Nuclear Medicine, University Hospital Düsseldorf, Moorenstr. 5, D-40225, Düsseldorf, Germany.Department of Diagnostic and Interventional Radiology, University Hospital Düsseldorf, Moorenstr. 5, D-40225, Düsseldorf, Germany.Clinic of Nuclear Medicine, University Hospital Düsseldorf, Moorenstr. 5, D-40225, Düsseldorf, Germany.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32619197

Citation

Nikolaus, Susanne, et al. "GABAergic and Glutamatergic Effects On Nigrostriatal and Mesolimbic Dopamine Release in the Rat." Reviews in the Neurosciences, 2020.
Nikolaus S, Beu M, Wittsack HJ, et al. GABAergic and glutamatergic effects on nigrostriatal and mesolimbic dopamine release in the rat. Rev Neurosci. 2020.
Nikolaus, S., Beu, M., Wittsack, H. J., Müller-Lutz, A., Antke, C., Hautzel, H., Mori, Y., Mamlins, E., Antoch, G., & Müller, H. W. (2020). GABAergic and glutamatergic effects on nigrostriatal and mesolimbic dopamine release in the rat. Reviews in the Neurosciences. https://doi.org/10.1515/revneuro-2019-0112
Nikolaus S, et al. GABAergic and Glutamatergic Effects On Nigrostriatal and Mesolimbic Dopamine Release in the Rat. Rev Neurosci. 2020 Jul 3; PubMed PMID: 32619197.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - GABAergic and glutamatergic effects on nigrostriatal and mesolimbic dopamine release in the rat. AU - Nikolaus,Susanne, AU - Beu,Markus, AU - Wittsack,Hans-Jörg, AU - Müller-Lutz,Anja, AU - Antke,Christina, AU - Hautzel,Hubertus, AU - Mori,Yuriko, AU - Mamlins,Eduards, AU - Antoch,Gerald, AU - Müller,Hans-Wilhelm, Y1 - 2020/07/03/ PY - 2019/12/02/received PY - 2020/02/01/accepted PY - 2020/7/4/entrez PY - 2020/7/4/pubmed PY - 2020/7/4/medline KW - D-cycloserine KW - D2/3 receptor KW - GABAA receptor KW - NMDA receptor KW - amantadine KW - bicuculline KW - muscimol KW - network analysis JF - Reviews in the neurosciences JO - Rev Neurosci N2 - In this review, a series of experiments is presented, in which γ-amino butyric acid (GABA)ergic and glutamatergic effects on dopamine function in the rat nigrostriatal and mesolimbic system was systematically assessed after pharmacological challenge with GABAA receptor (R) and and N-methyl d-aspartate (NMDA)R agonists and antagonists. In these studies, [123I]iodobenzamide binding to the D2/3R was mesured in nucleus accumbens (NAC), caudateputamen (CP), substantia nigra/ventral tegmental area (SN/VTA), frontal (FC), motor (MC) and parietal cortex (PC) as well as anterior (aHIPP) and posterior hippocampus (pHIPP) with small animal SPECT in baseline and after injection of either the GABAAR agonist muscimol (1 mg/kg), the GABAAR antagonist bicuculline (1 mg/kg), the NMDAR agonist d-cycloserine (20 mg/kg) or the NMDAR antagonist amantadine (40 mg/kg). Muscimol reduced D2/3R binding in NAC, CP, SN/VTA, THAL and pHIPP, while, after amantadine, decreases were confined to NAC, CP and THAL. In contrast, d-cycloserine elevated D2/3R binding in NAC, SN/VTA, THAL, frontal cortex, motor cortex, PC, aHIPP and pHIPP, while, after bicuculline, increases were confined to CP and THAL. Taken together, similar actions on regional dopamine levels were exterted by the GABAAR agonist and the NMDAR antagonist on the one side and by the GABAAR antagonist and the NMDAR agonist on the other, with agonistic action, however, affecting more brain regions. Thereby, network analysis suggests different roles of GABAARs and NMDARs in the mediation of nigrostriatal, nigrothalamocortical and mesolimbocortical dopamine function. SN - 0334-1763 UR - https://www.unboundmedicine.com/medline/citation/32619197/GABAergic_and_glutamatergic_effects_on_nigrostriatal_and_mesolimbic_dopamine_release_in_the_rat L2 - https://www.degruyter.com/doi/10.1515/revneuro-2019-0112 DB - PRIME DP - Unbound Medicine ER -
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