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One for All: A Pooled Approach to Classify Functional Impacts of Multiple Mutations.
Cell Stem Cell. 2020 Jul 02; 27(1):1-3.CS

Abstract

Understanding common biological consequences of heterogenous mutations in complex polygenic conditions is challenging. In this issue of Cell Stem Cell, Cederquist et al. (2020) implement an in vitro pooled assay where 30 high-confidence ASD mutations engineered in subclones of a human pluripotent stem cell line can be investigated in parallel to reveal their effects on prefrontal cortex neurogenesis.

Authors+Show Affiliations

Child Study Center, Yale University, New Haven, CT 06520, USA.Child Study Center, Yale University, New Haven, CT 06520, USA; Department of Neuroscience, Yale University, New Haven, CT 06520, USA. Electronic address: flora.vaccarino@yale.edu.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32619508

Citation

Jourdon, Alexandre, and Flora M. Vaccarino. "One for All: a Pooled Approach to Classify Functional Impacts of Multiple Mutations." Cell Stem Cell, vol. 27, no. 1, 2020, pp. 1-3.
Jourdon A, Vaccarino FM. One for All: A Pooled Approach to Classify Functional Impacts of Multiple Mutations. Cell Stem Cell. 2020;27(1):1-3.
Jourdon, A., & Vaccarino, F. M. (2020). One for All: A Pooled Approach to Classify Functional Impacts of Multiple Mutations. Cell Stem Cell, 27(1), 1-3. https://doi.org/10.1016/j.stem.2020.06.016
Jourdon A, Vaccarino FM. One for All: a Pooled Approach to Classify Functional Impacts of Multiple Mutations. Cell Stem Cell. 2020 Jul 2;27(1):1-3. PubMed PMID: 32619508.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - One for All: A Pooled Approach to Classify Functional Impacts of Multiple Mutations. AU - Jourdon,Alexandre, AU - Vaccarino,Flora M, PY - 2020/7/4/entrez PY - 2020/7/4/pubmed PY - 2020/7/4/medline SP - 1 EP - 3 JF - Cell stem cell JO - Cell Stem Cell VL - 27 IS - 1 N2 - Understanding common biological consequences of heterogenous mutations in complex polygenic conditions is challenging. In this issue of Cell Stem Cell, Cederquist et al. (2020) implement an in vitro pooled assay where 30 high-confidence ASD mutations engineered in subclones of a human pluripotent stem cell line can be investigated in parallel to reveal their effects on prefrontal cortex neurogenesis. SN - 1875-9777 UR - https://www.unboundmedicine.com/medline/citation/32619508/One_for_All:_A_Pooled_Approach_to_Classify_Functional_Impacts_of_Multiple_Mutations L2 - https://linkinghub.elsevier.com/retrieve/pii/S1934-5909(20)30283-6 DB - PRIME DP - Unbound Medicine ER -
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