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Gene regulatory networks in Drosophila early embryonic development as a model for the study of the temporal identity of neuroblasts.
Biosystems. 2020 Jun 30 [Online ahead of print]B

Abstract

Genes belonging to the "gap" and "gap-like" family constitute the best-studied gene regulatory networks (GRNs) in Drosophila embryogenesis. Gap genes are a core of two subnetworks controlling embryonic segmentation: (hunchback, hb; Krüppel, Kr; giant, gt; and knirps, kni) and (hb; Kr; pou-domain, pdm; and, probably, castor, cas). Of particular interest is that (hb, Kr, pdm, cas) also specifies the temporal identity of stem cells, neuroblasts, in Drosophila neurogenesis. This GRN controls the sequential differentiation of neuroblasts during the asymmetric cell division. In the last decades, modeling of the patterning of gene ensemble (hb, Kr, gt, kni) in segmentation was in the center of attention. We show that our previously published and extensively studied model at a certain level of external factors is able to reproduce temporal patterns of (hb, Kr, pdm, cas) in neurogenesis with minor evolutionary explicable modifications. This result testifies in favor of a hypothesis that the similarity of two gene ensembles active in segmentation and neurogenesis is a result of co-option of the network architecture in evolution from the common ancestral form. By means of the model dynamical analysis, it is shown that the establishment of the robust patterns in both systems could be explained in terms of the action of attractors in the gap gene dynamical system. We formulate the common principles underlying the robustness of both GRNs in segmentation and neurogenesis due to the similar functional organization of the gene ensembles as having the same evolutionary origin.

Authors+Show Affiliations

Peter the Great Saint-Petersburg Polytechnical University, 29 Politekhnicheskaya str, St. Petersburg, 195251, Russia. Electronic address: ekmyasnikova@yandex.ru.I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry Russian Academy of Sciences, 44 Thorez Pr, St.Petersburg, 194223, Russia; Computer Science and CEWIT, SUNY Stony Brook, Stony Brook, 1500 Stony Brook Road, Stony Brook, 11794, NY, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32619531

Citation

Myasnikova, Ekaterina, and Alexander Spirov. "Gene Regulatory Networks in Drosophila Early Embryonic Development as a Model for the Study of the Temporal Identity of Neuroblasts." Bio Systems, 2020, p. 104192.
Myasnikova E, Spirov A. Gene regulatory networks in Drosophila early embryonic development as a model for the study of the temporal identity of neuroblasts. BioSystems. 2020.
Myasnikova, E., & Spirov, A. (2020). Gene regulatory networks in Drosophila early embryonic development as a model for the study of the temporal identity of neuroblasts. Bio Systems, 104192. https://doi.org/10.1016/j.biosystems.2020.104192
Myasnikova E, Spirov A. Gene Regulatory Networks in Drosophila Early Embryonic Development as a Model for the Study of the Temporal Identity of Neuroblasts. BioSystems. 2020 Jun 30;104192. PubMed PMID: 32619531.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gene regulatory networks in Drosophila early embryonic development as a model for the study of the temporal identity of neuroblasts. AU - Myasnikova,Ekaterina, AU - Spirov,Alexander, Y1 - 2020/06/30/ PY - 2020/01/07/received PY - 2020/04/30/revised PY - 2020/06/21/accepted PY - 2020/7/4/entrez PY - 2020/7/4/pubmed PY - 2020/7/4/medline KW - Drosophila neurogenesis KW - Drosophila segmentation KW - Evolution KW - Gap genes KW - Gene circuit model KW - Robustness KW - Spatiotemporal patterning KW - Temporal identity of neuroblasts SP - 104192 EP - 104192 JF - Bio Systems JO - BioSystems N2 - Genes belonging to the "gap" and "gap-like" family constitute the best-studied gene regulatory networks (GRNs) in Drosophila embryogenesis. Gap genes are a core of two subnetworks controlling embryonic segmentation: (hunchback, hb; Krüppel, Kr; giant, gt; and knirps, kni) and (hb; Kr; pou-domain, pdm; and, probably, castor, cas). Of particular interest is that (hb, Kr, pdm, cas) also specifies the temporal identity of stem cells, neuroblasts, in Drosophila neurogenesis. This GRN controls the sequential differentiation of neuroblasts during the asymmetric cell division. In the last decades, modeling of the patterning of gene ensemble (hb, Kr, gt, kni) in segmentation was in the center of attention. We show that our previously published and extensively studied model at a certain level of external factors is able to reproduce temporal patterns of (hb, Kr, pdm, cas) in neurogenesis with minor evolutionary explicable modifications. This result testifies in favor of a hypothesis that the similarity of two gene ensembles active in segmentation and neurogenesis is a result of co-option of the network architecture in evolution from the common ancestral form. By means of the model dynamical analysis, it is shown that the establishment of the robust patterns in both systems could be explained in terms of the action of attractors in the gap gene dynamical system. We formulate the common principles underlying the robustness of both GRNs in segmentation and neurogenesis due to the similar functional organization of the gene ensembles as having the same evolutionary origin. SN - 1872-8324 UR - https://www.unboundmedicine.com/medline/citation/32619531/Gene_regulatory_networks_in_Drosophila_early_embryonic_development_as_a_model_for_the_study_of_the_temporal_identity_of_neuroblasts L2 - https://linkinghub.elsevier.com/retrieve/pii/S0303-2647(20)30087-3 DB - PRIME DP - Unbound Medicine ER -
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