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Allocentric coordinate spatial representations are impaired in aMCI and Alzheimer's disease patients.
Behav Brain Res. 2020 Sep 01; 393:112793.BB

Abstract

Research has reported deficits in egocentric (subject-to-object) and mainly allocentric (object-to-object) spatial representations in the early stages of the Alzheimer's disease (eAD). To identify early cognitive signs of neurodegenerative conversion, several studies have shown alterations in both reference frames, especially the allocentric ones in amnestic-Mild Cognitive Impairment (aMCI) and eAD patients. However, egocentric and allocentric spatial frames of reference are intrinsically connected with coordinate (metric/variant) and categorical (non-metric/invariant) spatial relations. This raises the question of whether allocentric deficit found to detect the conversion from aMCI to dementia is differently affected when combined with categorical or coordinate spatial relations. Here, we compared eAD and aMCI patients to Normal Controls (NC) on the Ego-Allo/Cat-Coor spatial memory task. Participants memorized triads of objects and then were asked to provide right/left (i.e. categorical) and distance based (i.e. coordinate) judgments according to an egocentric or allocentric reference frame. Results showed a selective deficit of coordinate, but not categorical, allocentric judgments in both aMCI and eAD patients as compared to NC group. These results suggest that a sign of the departure from normal/healthy aging towards the AD may be traced in elderly people's inability to represent metric distances among elements in the space.

Authors+Show Affiliations

Laboratory of Cognitive Science and Immersive Virtual Reality, CS-IVR, Department of Psychology, University of Campania L. Vanvitelli, Caserta, Italy. Electronic address: gennaro.ruggiero@unicampania.it.Laboratory of Cognitive Science and Immersive Virtual Reality, CS-IVR, Department of Psychology, University of Campania L. Vanvitelli, Caserta, Italy.Laboratory of Clinical Neuropsychology, Neurological Unit of "Ospedali dei Colli", Naples, Italy.Laboratory of Cognitive Science and Immersive Virtual Reality, CS-IVR, Department of Psychology, University of Campania L. Vanvitelli, Caserta, Italy.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32619567

Citation

Ruggiero, Gennaro, et al. "Allocentric Coordinate Spatial Representations Are Impaired in aMCI and Alzheimer's Disease Patients." Behavioural Brain Research, vol. 393, 2020, p. 112793.
Ruggiero G, Ruotolo F, Iavarone A, et al. Allocentric coordinate spatial representations are impaired in aMCI and Alzheimer's disease patients. Behav Brain Res. 2020;393:112793.
Ruggiero, G., Ruotolo, F., Iavarone, A., & Iachini, T. (2020). Allocentric coordinate spatial representations are impaired in aMCI and Alzheimer's disease patients. Behavioural Brain Research, 393, 112793. https://doi.org/10.1016/j.bbr.2020.112793
Ruggiero G, et al. Allocentric Coordinate Spatial Representations Are Impaired in aMCI and Alzheimer's Disease Patients. Behav Brain Res. 2020 Sep 1;393:112793. PubMed PMID: 32619567.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Allocentric coordinate spatial representations are impaired in aMCI and Alzheimer's disease patients. AU - Ruggiero,Gennaro, AU - Ruotolo,Francesco, AU - Iavarone,Alessandro, AU - Iachini,Tina, Y1 - 2020/06/30/ PY - 2020/02/24/received PY - 2020/06/19/revised PY - 2020/06/27/accepted PY - 2020/7/4/pubmed PY - 2020/7/4/medline PY - 2020/7/4/entrez KW - Categorical-coordinate spatial relations KW - Egocentric-allocentric representations KW - Visuo-spatial memory disorders KW - aMCI KW - eAD SP - 112793 EP - 112793 JF - Behavioural brain research JO - Behav. Brain Res. VL - 393 N2 - Research has reported deficits in egocentric (subject-to-object) and mainly allocentric (object-to-object) spatial representations in the early stages of the Alzheimer's disease (eAD). To identify early cognitive signs of neurodegenerative conversion, several studies have shown alterations in both reference frames, especially the allocentric ones in amnestic-Mild Cognitive Impairment (aMCI) and eAD patients. However, egocentric and allocentric spatial frames of reference are intrinsically connected with coordinate (metric/variant) and categorical (non-metric/invariant) spatial relations. This raises the question of whether allocentric deficit found to detect the conversion from aMCI to dementia is differently affected when combined with categorical or coordinate spatial relations. Here, we compared eAD and aMCI patients to Normal Controls (NC) on the Ego-Allo/Cat-Coor spatial memory task. Participants memorized triads of objects and then were asked to provide right/left (i.e. categorical) and distance based (i.e. coordinate) judgments according to an egocentric or allocentric reference frame. Results showed a selective deficit of coordinate, but not categorical, allocentric judgments in both aMCI and eAD patients as compared to NC group. These results suggest that a sign of the departure from normal/healthy aging towards the AD may be traced in elderly people's inability to represent metric distances among elements in the space. SN - 1872-7549 UR - https://www.unboundmedicine.com/medline/citation/32619567/Allocentric_coordinate_spatial_representations_are_impaired_in_aMCI_and_Alzheimer's_disease_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(20)30492-7 DB - PRIME DP - Unbound Medicine ER -
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