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Clinical recurrences of COVID-19 symptoms after recovery: viral relapse, reinfection or inflammatory rebound?
J Infect. 2020 Jun 30 [Online ahead of print]JI

Abstract

For the first 3 months of COVID-19 pandemic, COVID-19 was expected to be an immunizing non-relapsing disease. We report a national case series of 11 virologically-confirmed COVID-19 patients having experienced a second clinically- and virologically-confirmed acute COVID-19 episode. According to the clinical history, we discuss either re-infection or reactivation hypothesis. Larger studies including further virological, immunological and epidemiologic data are needed to understand the mechanisms of these recurrences.

Authors+Show Affiliations

Department of Infectious Diseases and Immunology, Cochin-Hôtel-Dieu Hospital, Publique -Hôpitaux de Paris (APHP), University of Paris. 1, place parvis Notre Dame, 75014 Paris.Service de Maladies Infectieuses et Tropicales, Hôpital de La Croix-Rousse, Hospices Civils, de Lyon, 103, Grande rue de La Croix-Rousse, 69004 Lyon. Electronic address: nicolas.benech@chu-lyon.fr.Infectious Diseases Department, University Hospital of Saint-Etienne, 42055 cedex 02 Saint-Etienne, GIMAP (EA 3064); University of Saint-Etienne, University of Lyon, Faculty of Medicine of Saint-Etienne, 42023 cedex 02 Saint-Etienne. Electronic address: elisabeth.botelho-nevers@chu-st-etienne.fr.Department of infectious disease, University Hospital of Besançon, F-25000 Besançon, France; UMR-CNRS 6249 Chrono-environnement, Université Bourgogne Franche-Comté, 25000 Besançon. Electronic address: kbouiller@chu-besancon.fr.Service des Maladies infectieuses et tropicales, Assistance publique- hôpitaux de Paris, Centre hospitalier universitaire Bicêtre, 78 rue du général Leclerc, 94270 Le Kremlin-Bicêtre. Electronic address: rocco.collarino@aphp.fr.Service de Maladies Infectieuses et Tropicales, Hôpital de La Croix-Rousse, Hospices Civils, de Lyon, 103, Grande rue de La Croix-Rousse, 69004 Lyon. Electronic address: anne.conrad@chu-lyon.fr.Service Médecine Interne, Pr Hot, INMG CNRS UMR5310 INSERM U1217, Place d'arsonvaal, 69003 Lyon. Electronic address: laure.gallay@chu-lyon.fr.Service de Maladies Infectieuses et Tropicales, Centre Régional Universitaire de Nancy, Hôpitaux de Brabois, Rue du Morvan, 54511 Vandoeuvre Lés Nancy. Electronic address: f.goehringer@chru-nancy.fr.Service de Medecine interne, Maladies Infectieuses, hematologie, Centre Hospitalier Bretagne Atlantique, 20, boulevard Maurice Guillaudot, 56000 Vannes. Electronic address: marie.gousseff@ch-bretagne-atlantique.fr.Service des Maladies Infectieuses et Tropicales, CHU Amiens-Picardie, Place Victor Pauchet 80054 Amiens. Electronic address: joseph.cedric@chu-amiens.fr.Service de Médecine Interne et Maladies Infectieuses, CHRU de Tours, Hôpital Bretonneau, Université de Tours, 2, Boulevard Tonnellé, 37000 Tours. Electronic address: adrien.lemaignen@univ-tours.fr.1-AP-HP, Infectious and Tropical Diseases Department, Bichat-Claude Bernard University, Hospital, Paris, France; 2 - University of Paris, French Institute for Health and Medical Research (INSERM), IAME, U1137, Team DesCID, Paris, France. 46 rue Henri Huchard, 75018 paris. Electronic address: xavier.lescure@aphp.fr.Service de Médecine Intensive et Reanimation Brabois, CHRU Nancy, Pôle Cardio-Médico-Chirurgical, Vandoeuvre-les-Nancy, INSERM U1116, Faculté de Médecine, Vandoeuvre-les-Nancy, and Université de Lorraine. Electronic address: blevy5463@gmail.com.Service de Médecine Interne, Centre Hospitalier Universitaire Henri-Mondor, Assistance Publique-Hôpitaux de Paris, Université Paris Est Créteil, Créteil, France. IMRB - U955 - INSERM Equipe n°2 "Transfusion et maladies du globule rouge" EFS Île-de-France, Hôpital Henri-Mondor, AP-HP, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil. Electronic address: matthieu.mahevas@aphp.fr.Hôpital intercommunal André Grégoire, groupement hospitalier Grand Paris Nord Est, 56, boulevard de la Boissière, 93100 Montreuil. Electronic address: pauline.penot@ght-gpne.fr.GIMAP (EA 3064), University of Saint-Etienne, University of Lyon, Faculty of Medicine of Saint-Etienne, 42023 cedex 02 Saint-Etienne. Electronic address: bruno.pozzetto@chu-st-etienne.fr.Department of Infectious Diseases and Immunology, Cochin-Hôtel-Dieu Hospital, Assistance, Publique -Hôpitaux de Paris (APHP), University of Paris. 1, place parvis Notre Dame, 75014 Paris. Electronic address: Dominique.salmon@aphp.fr.Department of Infectious Diseases and Immunology, Cochin-Hôtel-Dieu Hospital, Assistance, Publique -Hôpitaux de Paris (APHP), University of Paris. 1, place parvis Notre Dame, 75014 Paris. Electronic address: dorssaf.slama@gmail.com.Groupe hospitalier Sud Ile de France & INSERM, Institut Pierre Louis d'Épidémiologie et de, Santé Publique (IPLESP), Sorbonne Université, Paris, France, 270 avenue Marc Jacquet, 77 000 Melun. Electronic address: dr.vignier@gmail.com.Service des Maladies infectieuses et tropicales, Assistance publique- hôpitaux de Paris, Centre hospitalier universitaire Bicêtre, 78 rue du général Leclerc, 94270 Le Kremlin-Bicêtre. Electronic address: Benjamin.wyplosz@aphp.fr.

Pub Type(s)

Letter

Language

eng

PubMed ID

32619697

Citation

Batisse, Dominique, et al. "Clinical Recurrences of COVID-19 Symptoms After Recovery: Viral Relapse, Reinfection or Inflammatory Rebound?" The Journal of Infection, 2020.
Batisse D, Benech N, Botelho-Nevers E, et al. Clinical recurrences of COVID-19 symptoms after recovery: viral relapse, reinfection or inflammatory rebound? J Infect. 2020.
Batisse, D., Benech, N., Botelho-Nevers, E., Bouiller, K., Collarino, R., Conrad, A., Gallay, L., Goehringer, F., Gousseff, M., Joseph, D. C., Lemaignen, A., Lescure, F. X., Levy, B., Mahevas, M., Penot, P., Pozzetto, B., Salmon, D., Slama, D., Vignier, N., & Wyplosz, B. (2020). Clinical recurrences of COVID-19 symptoms after recovery: viral relapse, reinfection or inflammatory rebound? The Journal of Infection. https://doi.org/10.1016/j.jinf.2020.06.073
Batisse D, et al. Clinical Recurrences of COVID-19 Symptoms After Recovery: Viral Relapse, Reinfection or Inflammatory Rebound. J Infect. 2020 Jun 30; PubMed PMID: 32619697.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical recurrences of COVID-19 symptoms after recovery: viral relapse, reinfection or inflammatory rebound? AU - Batisse,Dominique, AU - Benech,Nicolas, AU - Botelho-Nevers,Elisabeth, AU - Bouiller,Kevin, AU - Collarino,Rocco, AU - Conrad,Anne, AU - Gallay,Laure, AU - Goehringer,Francois, AU - Gousseff,Marie, AU - Joseph,Dr Cédric, AU - Lemaignen,Adrien, AU - Lescure,François-Xavier, AU - Levy,Bruno, AU - Mahevas,Matthieu, AU - Penot,Pauline, AU - Pozzetto,Bruno, AU - Salmon,Dominique, AU - Slama,Dorsaf, AU - Vignier,Nicolas, AU - Wyplosz,Benjamin, Y1 - 2020/06/30/ PY - 2020/06/26/received PY - 2020/06/28/accepted PY - 2020/7/4/entrez PY - 2020/7/4/pubmed PY - 2020/7/4/medline JF - The Journal of infection JO - J. Infect. N2 - For the first 3 months of COVID-19 pandemic, COVID-19 was expected to be an immunizing non-relapsing disease. We report a national case series of 11 virologically-confirmed COVID-19 patients having experienced a second clinically- and virologically-confirmed acute COVID-19 episode. According to the clinical history, we discuss either re-infection or reactivation hypothesis. Larger studies including further virological, immunological and epidemiologic data are needed to understand the mechanisms of these recurrences. SN - 1532-2742 UR - https://www.unboundmedicine.com/medline/citation/32619697/Clinical_recurrences_of_COVID-19_symptoms_after_recovery:_viral_relapse,_reinfection_or_inflammatory_rebound L2 - https://linkinghub.elsevier.com/retrieve/pii/S0163-4453(20)30454-0 DB - PRIME DP - Unbound Medicine ER -
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