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Magnetically-driven implantable pump for on-demand bolus infusion of short-acting glucagon-like peptide-1 receptor agonist.
J Control Release. 2020 Jun 30; 325:111-120.JC

Abstract

For type 2 diabetic patients, short acting glucagon-like peptide-1 receptor agonist (GLP-1 RA) is often prescribed with frequent needled injections. Long-acting GLP-1 RA for less frequent injections do not mimic physiologic secretion of GLP-1. Therefore, an implantable pump is proposed in this work, which can deliver a short-acting GLP-1 RA, exenatide, without needles and batteries. The implanted pump can infuse an accurate amount of exenatide bolus only when a noninvasive magnetic force is applied from outside the body. The pump includes a safety feature of patterned magnets for actuation to prevent accidental infusion possibly caused by a general household magnet. The reservoir for exenatide is made of a flexible biomaterial and thus, a negative pressure build-up in the reservoir can be prevented even after multiple actuations and almost all drug consumption (~ 94%). This allows a reproducible drug dose for a longer period after implantation, hence less frequent replenishment procedures. The pump is also equipped with an intermediate container with two distinct check-valves and thus, the reservoir of exenatide can be further separated and better prevented from infiltration of the bodily fluid surrounding the implanted pump. When tested in Goto-Kakizaki rats, the pump demonstrates the efficacy of exenatide similar to conventional subcutaneous injections. Therefore, the pump can be promising for patient-friendly, optimal delivery of short-acting GLP-1 RA that better follows the physiologic secretion profile of GLP-1.

Authors+Show Affiliations

Institute of Medical and Biological Engineering, Medical Research Center, Seoul National University, Seoul 03080, Republic of Korea.Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea; Department of Translational Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University, Seoul 08826, Republic of Korea.Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University, Seoul 08826, Republic of Korea.Department of Translational Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University, Seoul 08826, Republic of Korea.Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea; Department of Translational Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.Department of Biomedical Engineering, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.Department of Pathology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea; Department of Translational Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea. Electronic address: ymchomd@snu.ac.kr.Institute of Medical and Biological Engineering, Medical Research Center, Seoul National University, Seoul 03080, Republic of Korea; Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University, Seoul 08826, Republic of Korea; Department of Biomedical Engineering, Seoul National University College of Medicine, Seoul 03080, Republic of Korea. Electronic address: ybchoy@snu.ac.kr.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32619744

Citation

Lee, Seung Ho, et al. "Magnetically-driven Implantable Pump for On-demand Bolus Infusion of Short-acting Glucagon-like Peptide-1 Receptor Agonist." Journal of Controlled Release : Official Journal of the Controlled Release Society, vol. 325, 2020, pp. 111-120.
Lee SH, Min SH, Cho YC, et al. Magnetically-driven implantable pump for on-demand bolus infusion of short-acting glucagon-like peptide-1 receptor agonist. J Control Release. 2020;325:111-120.
Lee, S. H., Min, S. H., Cho, Y. C., Han, J. H., Kim, M. N., Kim, C. R., Ahn, C. H., Kim, B. H., Lee, C., Cho, Y. M., & Choy, Y. B. (2020). Magnetically-driven implantable pump for on-demand bolus infusion of short-acting glucagon-like peptide-1 receptor agonist. Journal of Controlled Release : Official Journal of the Controlled Release Society, 325, 111-120. https://doi.org/10.1016/j.jconrel.2020.06.022
Lee SH, et al. Magnetically-driven Implantable Pump for On-demand Bolus Infusion of Short-acting Glucagon-like Peptide-1 Receptor Agonist. J Control Release. 2020 Jun 30;325:111-120. PubMed PMID: 32619744.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Magnetically-driven implantable pump for on-demand bolus infusion of short-acting glucagon-like peptide-1 receptor agonist. AU - Lee,Seung Ho, AU - Min,Se Hee, AU - Cho,Yong Chan, AU - Han,Jae Hoon, AU - Kim,Mi Na, AU - Kim,Cho Rim, AU - Ahn,Chang Ho, AU - Kim,Byung Hwi, AU - Lee,Cheol, AU - Cho,Young Min, AU - Choy,Young Bin, Y1 - 2020/06/30/ PY - 2020/03/13/received PY - 2020/06/12/revised PY - 2020/06/21/accepted PY - 2020/7/4/pubmed PY - 2020/7/4/medline PY - 2020/7/4/entrez KW - Exenatide KW - Glucagon-like peptide-1 receptor agonist KW - Implantable pump KW - On-demand drug delivery KW - Type 2 diabetes SP - 111 EP - 120 JF - Journal of controlled release : official journal of the Controlled Release Society JO - J Control Release VL - 325 N2 - For type 2 diabetic patients, short acting glucagon-like peptide-1 receptor agonist (GLP-1 RA) is often prescribed with frequent needled injections. Long-acting GLP-1 RA for less frequent injections do not mimic physiologic secretion of GLP-1. Therefore, an implantable pump is proposed in this work, which can deliver a short-acting GLP-1 RA, exenatide, without needles and batteries. The implanted pump can infuse an accurate amount of exenatide bolus only when a noninvasive magnetic force is applied from outside the body. The pump includes a safety feature of patterned magnets for actuation to prevent accidental infusion possibly caused by a general household magnet. The reservoir for exenatide is made of a flexible biomaterial and thus, a negative pressure build-up in the reservoir can be prevented even after multiple actuations and almost all drug consumption (~ 94%). This allows a reproducible drug dose for a longer period after implantation, hence less frequent replenishment procedures. The pump is also equipped with an intermediate container with two distinct check-valves and thus, the reservoir of exenatide can be further separated and better prevented from infiltration of the bodily fluid surrounding the implanted pump. When tested in Goto-Kakizaki rats, the pump demonstrates the efficacy of exenatide similar to conventional subcutaneous injections. Therefore, the pump can be promising for patient-friendly, optimal delivery of short-acting GLP-1 RA that better follows the physiologic secretion profile of GLP-1. SN - 1873-4995 UR - https://www.unboundmedicine.com/medline/citation/32619744/Magnetically-driven_implantable_pump_for_on-demand_bolus_infusion_of_short-acting_glucagon-like_peptide-1_receptor_agonist L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-3659(20)30356-4 DB - PRIME DP - Unbound Medicine ER -
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