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Efficient T cell compartment in HIV+ patients receiving orthotopic liver transplant and immunosuppressive therapy.
J Infect Dis. 2020 Jul 04 [Online ahead of print]JI

Abstract

BACKGROUND AND AIMS

In patients undergoing orthotopic liver transplant (OLT), immunosuppressive (IS) treatment is mandatory and infections are leading causes of morbidity/mortality. Thus, it is essential to understand the functionality of cell-mediated immunity after OLT. The aim of the study was to identify changes in T cell phenotype and polyfunctionality in HIV+ and HIV- patients treated with IS after OLT.

METHODS

We studied peripheral blood mononuclear cells from 108 subjects divided in 4 groups of 27: HIV+ transplanted patients; HIV- transplanted patients; HIV+ non-transplanted patients; healthy subjects. T cell activation, differentiation and cytokine production were analyzed by flow cytometry.

RESULTS

Median age was 55 years (52-59), median CD4 count in HIV+ patients was 567 cells/mL, all had undetectable viral load. CD4+ and CD8+ T cell subpopulations showed different distributions between HIV+ and HIV- OLT patients. A cluster representing effector cells expressing PD1 was abundant in HIV- transplanted patients and they were characterized by higher levels of CD4+ T cells able to produce IFN-g and TNF-a.

CONCLUSIONS

HIV- transplanted patients have more exhausted or inflammatory T cells compared to HIV+ transplanted patients, suggesting that patients who already experienced a form of immunosuppression due to HIV infection respond differently to anti-rejection therapy.

Authors+Show Affiliations

Clinic of Infectious Diseases, University Hospital, Modena, Italy.Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Modena, Italy.Clinic of Infectious Diseases, University Hospital, Modena, Italy.Department of Surgical, Medical, Dental and Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy.Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Modena, Italy.Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Modena, Italy.Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Modena, Italy.Clinic of Infectious Diseases, University Hospital, Modena, Italy.Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit, University Hospital, Modena, Italy.Department of Surgical, Medical, Dental and Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy.Clinic of Infectious Diseases, University Hospital, Modena, Italy.Clinic of Infectious Diseases, University Hospital, Modena, Italy. Department of Surgical, Medical, Dental and Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy.Department of Surgical, Medical, Dental and Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy. Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit, University Hospital, Modena, Italy.Department of Surgical, Medical, Dental and Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy. Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit, University Hospital, Modena, Italy.Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.Clinic of Infectious Diseases, University Hospital, Modena, Italy. Department of Surgical, Medical, Dental and Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy.Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Modena, Italy. Istituto Nazionale per le Ricerche Cardiovascolari, Bologna, Italy.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32620016

Citation

Franceschini, Erica, et al. "Efficient T Cell Compartment in HIV+ Patients Receiving Orthotopic Liver Transplant and Immunosuppressive Therapy." The Journal of Infectious Diseases, 2020.
Franceschini E, De Biasi S, Digaetano M, et al. Efficient T cell compartment in HIV+ patients receiving orthotopic liver transplant and immunosuppressive therapy. J Infect Dis. 2020.
Franceschini, E., De Biasi, S., Digaetano, M., Bianchini, E., Lo Tartaro, D., Gibellini, L., Menozzi, M., Zona, S., Tarantino, G., Nasi, M., Codeluppi, M., Guaraldi, G., Magistri, P., Di Benedetto, F., Pinti, M., Mussini, C., & Cossarizza, A. (2020). Efficient T cell compartment in HIV+ patients receiving orthotopic liver transplant and immunosuppressive therapy. The Journal of Infectious Diseases. https://doi.org/10.1093/infdis/jiaa395
Franceschini E, et al. Efficient T Cell Compartment in HIV+ Patients Receiving Orthotopic Liver Transplant and Immunosuppressive Therapy. J Infect Dis. 2020 Jul 4; PubMed PMID: 32620016.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficient T cell compartment in HIV+ patients receiving orthotopic liver transplant and immunosuppressive therapy. AU - Franceschini,Erica, AU - De Biasi,Sara, AU - Digaetano,Margherita, AU - Bianchini,Elena, AU - Lo Tartaro,Domenico, AU - Gibellini,Lara, AU - Menozzi,Marianna, AU - Zona,Stefano, AU - Tarantino,Giuseppe, AU - Nasi,Milena, AU - Codeluppi,Mauro, AU - Guaraldi,Giovanni, AU - Magistri,Paolo, AU - Di Benedetto,Fabrizio, AU - Pinti,Marcello, AU - Mussini,Cristina, AU - Cossarizza,Andrea, Y1 - 2020/07/04/ PY - 2020/02/12/received PY - 2020/7/4/entrez PY - 2020/7/4/pubmed PY - 2020/7/4/medline KW - ART KW - HIV KW - T cells KW - cytokine KW - liver transplantation JF - The Journal of infectious diseases JO - J. Infect. Dis. N2 - BACKGROUND AND AIMS: In patients undergoing orthotopic liver transplant (OLT), immunosuppressive (IS) treatment is mandatory and infections are leading causes of morbidity/mortality. Thus, it is essential to understand the functionality of cell-mediated immunity after OLT. The aim of the study was to identify changes in T cell phenotype and polyfunctionality in HIV+ and HIV- patients treated with IS after OLT. METHODS: We studied peripheral blood mononuclear cells from 108 subjects divided in 4 groups of 27: HIV+ transplanted patients; HIV- transplanted patients; HIV+ non-transplanted patients; healthy subjects. T cell activation, differentiation and cytokine production were analyzed by flow cytometry. RESULTS: Median age was 55 years (52-59), median CD4 count in HIV+ patients was 567 cells/mL, all had undetectable viral load. CD4+ and CD8+ T cell subpopulations showed different distributions between HIV+ and HIV- OLT patients. A cluster representing effector cells expressing PD1 was abundant in HIV- transplanted patients and they were characterized by higher levels of CD4+ T cells able to produce IFN-g and TNF-a. CONCLUSIONS: HIV- transplanted patients have more exhausted or inflammatory T cells compared to HIV+ transplanted patients, suggesting that patients who already experienced a form of immunosuppression due to HIV infection respond differently to anti-rejection therapy. SN - 1537-6613 UR - https://www.unboundmedicine.com/medline/citation/32620016/Efficient_T_cell_compartment_in_HIV+_patients_receiving_orthotopic_liver_transplant_and_immunosuppressive_therapy L2 - https://academic.oup.com/jid/article-lookup/doi/10.1093/infdis/jiaa395 DB - PRIME DP - Unbound Medicine ER -
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