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Swinging the pendulum: lessons learned from public discourse concerning hydroxychloroquine and COVID-19.
Expert Rev Clin Immunol. 2020 Jul 03 [Online ahead of print]ER

Abstract

INTRODUCTION

Several months into the COVID-19 pandemic, safe and effective treatments against this global health disaster have yet to be identified. Clinical research trials around the world are underway testing a wide array of possible medications. In particular, the off-label use of hydroxychloroquine for COVID-19 prophylaxis and treatment has created many unprecedented challenges for the scientific community and the public.

AREAS COVERED

We critically assessed major events from February - May 2020 that contributed to widespread use of hydroxychloroquine for the treatment and prophylaxis of COVID-19. We aimed to explore how opinions towards hydroxychloroquine may shift from early enthusiasm (based on in vitro and preliminary clinical data) to the hope for a miracle cure (through communication and promotion of questionable results) and, finally, to a rise of skepticism as more in-depth analyses are emerging.

EXPERT OPINION

Mindful and rigorous acquisition of data, as well as its interpretation, are essential to an effective pandemic response. The rapid and premature promotion of results has had major implications for global crisis management, even creating distrust among the public. It is crucial for the medical and scientific community to incorporate the lessons learned from this situation.

Authors+Show Affiliations

Division of Rheumatology, Department of Medicine, Hospital for Special Surgery , New York, NY, USA.Division of Rheumatology, Department of Medicine, University of Washington , Seattle, WA, USA.Division of Rheumatology and Clinical Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, MA, USA.Washington University School of Medicine , St. Louis, MO, USA.Department of Rheumatology, Sorbonne University, INSERM CRSA, AP-HP , Paris, France.Division of Rheumatology, Mayo Clinic , Rochester, MN, USA.LupusChat , New York, New York, USA.Division of Rheumatology, Department of Medicine, The Johns Hopkins University School of Medicine , Baltimore, MD, USA.Department of Nephrology and Rheumatology, University Medical Center Göttingen , Göttingen, Germany.Department of Medicine, Northwestern University , Chicago, IL, USA.University of Queensland Faculty of Medicine , Brisbane, Australia.Department of Health Research Methods, Evidence, and Impact, McMaster University , Hamilton, ON, Canada and Canadian Arthritis Patient Alliance, Toronto, ON, Canada.School of Medicine, Universidad Científica del Sur and Hospital Nacional Guillermo Almenara Irigoyen , EsSalud, Lima, Peru.Division of Rheumatology, Department of Medicine, Hospital for Special Surgery , New York, NY, USA. Department of Rheumatology, Sorbonne University, INSERM CRSA, AP-HP , Paris, France. University of Cape Town, Cape Town, South Africa, and the 15Francis Crick Institute , London, United Kingdom.Division of Rheumatic Diseases, UT Southwestern Medical Center , Dallas, TX, USA.Division of Rheumatology, Department of Medicine, Washington University School of Medicine , Saint Louis, MO, USA.Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Harvard Medical School , Boston, MA, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32620062

Citation

Sattui, Sebastian E., et al. "Swinging the Pendulum: Lessons Learned From Public Discourse Concerning Hydroxychloroquine and COVID-19." Expert Review of Clinical Immunology, 2020.
Sattui SE, Liew JW, Graef ER, et al. Swinging the pendulum: lessons learned from public discourse concerning hydroxychloroquine and COVID-19. Expert Rev Clin Immunol. 2020.
Sattui, S. E., Liew, J. W., Graef, E. R., Coler-Reilly, A., Berenbaum, F., Duarte-García, A., Harrison, C., Konig, M. F., Korsten, P., Putman, M. S., Robinson, P. C., Sirotich, E., Ugarte-Gil, M. F., Webb, K., Young, K. J., Kim, A. H. J., & Sparks, J. A. (2020). Swinging the pendulum: lessons learned from public discourse concerning hydroxychloroquine and COVID-19. Expert Review of Clinical Immunology. https://doi.org/10.1080/1744666X.2020.1792778
Sattui SE, et al. Swinging the Pendulum: Lessons Learned From Public Discourse Concerning Hydroxychloroquine and COVID-19. Expert Rev Clin Immunol. 2020 Jul 3; PubMed PMID: 32620062.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Swinging the pendulum: lessons learned from public discourse concerning hydroxychloroquine and COVID-19. AU - Sattui,Sebastian E, AU - Liew,Jean W, AU - Graef,Elizabeth R, AU - Coler-Reilly,Ariella, AU - Berenbaum,Francis, AU - Duarte-García,Alí, AU - Harrison,Carly, AU - Konig,Maximilian F, AU - Korsten,Peter, AU - Putman,Michael S, AU - Robinson,Philip C, AU - Sirotich,Emily, AU - Ugarte-Gil,Manuel F, AU - Webb,Kate, AU - Young,Kristen J, AU - Kim,Alfred H J, AU - Sparks,Jeffrey A, Y1 - 2020/07/03/ PY - 2020/7/5/entrez PY - 2020/7/6/pubmed PY - 2020/7/6/medline KW - Coronavirus disease 2019 KW - SARS-CoV-2 KW - antimalarials KW - chloroquine KW - hydroxychloroquine JF - Expert review of clinical immunology JO - Expert Rev Clin Immunol N2 - INTRODUCTION: Several months into the COVID-19 pandemic, safe and effective treatments against this global health disaster have yet to be identified. Clinical research trials around the world are underway testing a wide array of possible medications. In particular, the off-label use of hydroxychloroquine for COVID-19 prophylaxis and treatment has created many unprecedented challenges for the scientific community and the public. AREAS COVERED: We critically assessed major events from February - May 2020 that contributed to widespread use of hydroxychloroquine for the treatment and prophylaxis of COVID-19. We aimed to explore how opinions towards hydroxychloroquine may shift from early enthusiasm (based on in vitro and preliminary clinical data) to the hope for a miracle cure (through communication and promotion of questionable results) and, finally, to a rise of skepticism as more in-depth analyses are emerging. EXPERT OPINION: Mindful and rigorous acquisition of data, as well as its interpretation, are essential to an effective pandemic response. The rapid and premature promotion of results has had major implications for global crisis management, even creating distrust among the public. It is crucial for the medical and scientific community to incorporate the lessons learned from this situation. SN - 1744-8409 UR - https://www.unboundmedicine.com/medline/citation/32620062/Swinging_the_pendulum:_lessons_learned_from_public_discourse_concerning_hydroxychloroquine_and_COVID-19 L2 - http://www.tandfonline.com/doi/full/10.1080/1744666X.2020.1792778 DB - PRIME DP - Unbound Medicine ER -
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