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Therapeutic approaches in the treatment of gout.
Semin Arthritis Rheum. 2020 Jun; 50(3S):S24-S30.SA

Abstract

Gout is a disease in which the metabolic condition hyperuricemia leads to the formation of monosodium urate crystals, which provoke acute and chronic inflammatory responses through activation of the innate immune system. Recent advances in our knowledge of gout pathogenesis have emphasized the role of the kidneys in urate handling, the evolutionary loss of uricase as a necessary precondition for hyperuricemia, and the central role of IL-1β in the pathogenesis of gouty inflammation. These, and other advances, have shaped our current strategies for managing gout. Here, we review the most current, evidence-based gout management approaches, including treating acute flares, addressing gout through the long-term regulation of serum urate, and prophylaxis against gouty flares during urate lowering.

Authors+Show Affiliations

The Division of Rheumatology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, United States; The Section of Rheumatology, New York Harbor Health Care System, New York Campus of the U.S. Department of Veterans Affairs, New York, NY, United States. Electronic address: michael.pillinger@nyulangone.org.Rheumatic and Immunologic Diseases, The Cleveland Clinic, Cleveland, OH, United States.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32620199

Citation

Pillinger, Michael H., and Brian F. Mandell. "Therapeutic Approaches in the Treatment of Gout." Seminars in Arthritis and Rheumatism, vol. 50, no. 3S, 2020, pp. S24-S30.
Pillinger MH, Mandell BF. Therapeutic approaches in the treatment of gout. Semin Arthritis Rheum. 2020;50(3S):S24-S30.
Pillinger, M. H., & Mandell, B. F. (2020). Therapeutic approaches in the treatment of gout. Seminars in Arthritis and Rheumatism, 50(3S), S24-S30. https://doi.org/10.1016/j.semarthrit.2020.04.010
Pillinger MH, Mandell BF. Therapeutic Approaches in the Treatment of Gout. Semin Arthritis Rheum. 2020;50(3S):S24-S30. PubMed PMID: 32620199.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Therapeutic approaches in the treatment of gout. AU - Pillinger,Michael H, AU - Mandell,Brian F, PY - 2020/7/5/entrez PY - 2020/7/6/pubmed PY - 2020/7/6/medline KW - Allopurinol KW - Colchicine KW - Gout KW - Pegloticase KW - Treatment SP - S24 EP - S30 JF - Seminars in arthritis and rheumatism JO - Semin. Arthritis Rheum. VL - 50 IS - 3S N2 - Gout is a disease in which the metabolic condition hyperuricemia leads to the formation of monosodium urate crystals, which provoke acute and chronic inflammatory responses through activation of the innate immune system. Recent advances in our knowledge of gout pathogenesis have emphasized the role of the kidneys in urate handling, the evolutionary loss of uricase as a necessary precondition for hyperuricemia, and the central role of IL-1β in the pathogenesis of gouty inflammation. These, and other advances, have shaped our current strategies for managing gout. Here, we review the most current, evidence-based gout management approaches, including treating acute flares, addressing gout through the long-term regulation of serum urate, and prophylaxis against gouty flares during urate lowering. SN - 1532-866X UR - https://www.unboundmedicine.com/medline/citation/32620199/Therapeutic_approaches_in_the_treatment_of_gout L2 - https://linkinghub.elsevier.com/retrieve/pii/S0049-0172(20)30124-4 DB - PRIME DP - Unbound Medicine ER -
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