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Piper sarmentosum Roxb.: A review on its botany, traditional uses, phytochemistry, and pharmacological activities.
J Ethnopharmacol. 2020 Jun 30 [Online ahead of print]JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Piper sarmentosum Roxb. (Piperaceae) is a traditional medicinal plant widely distributed in India, Malaysia, Thailand, and the southeastern coastal areas of China including Fujian, Guangdong, and Guizhou. It has been used for centuries for the treatment of wind-cold cough, fever, rheumatism arthralgia, diarrhea dysentery, postpartum foot swelling, stomachache, toothache, diabetes, and traumatic injury.

AIMS OF THE REVIEW

To critically anayze the literature for the botany, traditional uses, phytochemistry, pharmacology, toxicity, and clinical trials of P. sarmentosum in order to provide a scientific consensus for further research and discovery of potential candidate drugs.

MATERIALS AND METHODS

The contents of this review were sourced from electronic databases including PubMed, SciFinder, Web of Science, Science Direct, Elsevier, Google Scholar, Chinese Knowledge On frastructure (CNKI), Wanfang, Chinese Scientific and Technological Periodical Database (VIP), Chinese Biomedical Database (CBM), Cochrane Controlled register of Clinical Trials, Clinical Trials. gov, and Chinese Clinical Trial Registry. Chinese medicine books published over the years were used to elucidate the traditional uses of P. sarmentosum and additional information was also collected from Yao Zhi website (https://db.yaozh.com/).

RESULTS

Phytochemical analyses of the chemical constituents of P. sarmentosum include essential oil, alkaloids, flavonoids, lignans, and steroids. The literature supports the ethnomedicinal uses of P. sarmentosum for the treatment of cold, gastritis, and rheumatoid joint pain, and further confirms its relatively new pharmacological activities, including anti-inflammatory, antineoplastic, and antipyretic activities. Other biological roles such as anti-osteoporosis, antibacterial, antidepressant, anti-atherosclerotic, and hypoglycemic activities have also been reported. However, the methodologies employed in individual studies are limited.

CONCLUSIONS

There is convincing evidence from both in vitro and in vivo studies supporting the traditional use of P. sarmentosum and it is imperative that natural bioactive compounds are examined further. More efforts should be focused on the pharmacodynamic constituents of P. sarmentosum to provide practical basis for quality control, and additional studies are needed to understand the mechanism of their action. Further studies on the comprehensive evaluation of medicinal quality and understandings of serum chemistry, multi-target network pharmacology, and molecular docking technology of P. sarmentosum are of great importance and should be considered.

Authors+Show Affiliations

School of Pharmacy, Shandong University of Traditional Chinese Medicine, 4655 Daxue Road, Jinan, 250355, China; Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai, 200433, China.School of Pharmacy, Shandong University of Traditional Chinese Medicine, 4655 Daxue Road, Jinan, 250355, China.School of Pharmacy, Shandong University of Traditional Chinese Medicine, 4655 Daxue Road, Jinan, 250355, China; Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai, 200433, China.Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai, 200433, China.Faculty of Science, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Byrom Street, Liverpool, L3 3AF, UK.Military Drug Research and Development Center, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai, 200433, China.Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai, 200433, China.School of Pharmacy, Shandong University of Traditional Chinese Medicine, 4655 Daxue Road, Jinan, 250355, China.School of Pharmacy, Shandong University of Traditional Chinese Medicine, 4655 Daxue Road, Jinan, 250355, China. Electronic address: xulingchuan518@sina.com.Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai, 200433, China. Electronic address: than927@163.com.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32620264

Citation

Sun, Xiaolei, et al. "Piper Sarmentosum Roxb.: a Review On Its Botany, Traditional Uses, Phytochemistry, and Pharmacological Activities." Journal of Ethnopharmacology, 2020, p. 112897.
Sun X, Chen W, Dai W, et al. Piper sarmentosum Roxb.: A review on its botany, traditional uses, phytochemistry, and pharmacological activities. J Ethnopharmacol. 2020.
Sun, X., Chen, W., Dai, W., Xin, H., Rahmand, K., Wang, Y., Zhang, J., Zhang, S., Xu, L., & Han, T. (2020). Piper sarmentosum Roxb.: A review on its botany, traditional uses, phytochemistry, and pharmacological activities. Journal of Ethnopharmacology, 112897. https://doi.org/10.1016/j.jep.2020.112897
Sun X, et al. Piper Sarmentosum Roxb.: a Review On Its Botany, Traditional Uses, Phytochemistry, and Pharmacological Activities. J Ethnopharmacol. 2020 Jun 30;112897. PubMed PMID: 32620264.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Piper sarmentosum Roxb.: A review on its botany, traditional uses, phytochemistry, and pharmacological activities. AU - Sun,Xiaolei, AU - Chen,Wenhua, AU - Dai,Wei, AU - Xin,Hailiang, AU - Rahmand,Khalid, AU - Wang,Yan, AU - Zhang,Jiabao, AU - Zhang,Shiyao, AU - Xu,Lingchuan, AU - Han,Ting, Y1 - 2020/06/30/ PY - 2019/11/01/received PY - 2020/04/14/revised PY - 2020/04/18/accepted PY - 2020/7/5/entrez KW - Pharmacology KW - Phytochemistry KW - Piper sarmentosum KW - Toxicity KW - Traditional uses SP - 112897 EP - 112897 JF - Journal of ethnopharmacology JO - J Ethnopharmacol N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Piper sarmentosum Roxb. (Piperaceae) is a traditional medicinal plant widely distributed in India, Malaysia, Thailand, and the southeastern coastal areas of China including Fujian, Guangdong, and Guizhou. It has been used for centuries for the treatment of wind-cold cough, fever, rheumatism arthralgia, diarrhea dysentery, postpartum foot swelling, stomachache, toothache, diabetes, and traumatic injury. AIMS OF THE REVIEW: To critically anayze the literature for the botany, traditional uses, phytochemistry, pharmacology, toxicity, and clinical trials of P. sarmentosum in order to provide a scientific consensus for further research and discovery of potential candidate drugs. MATERIALS AND METHODS: The contents of this review were sourced from electronic databases including PubMed, SciFinder, Web of Science, Science Direct, Elsevier, Google Scholar, Chinese Knowledge On frastructure (CNKI), Wanfang, Chinese Scientific and Technological Periodical Database (VIP), Chinese Biomedical Database (CBM), Cochrane Controlled register of Clinical Trials, Clinical Trials. gov, and Chinese Clinical Trial Registry. Chinese medicine books published over the years were used to elucidate the traditional uses of P. sarmentosum and additional information was also collected from Yao Zhi website (https://db.yaozh.com/). RESULTS: Phytochemical analyses of the chemical constituents of P. sarmentosum include essential oil, alkaloids, flavonoids, lignans, and steroids. The literature supports the ethnomedicinal uses of P. sarmentosum for the treatment of cold, gastritis, and rheumatoid joint pain, and further confirms its relatively new pharmacological activities, including anti-inflammatory, antineoplastic, and antipyretic activities. Other biological roles such as anti-osteoporosis, antibacterial, antidepressant, anti-atherosclerotic, and hypoglycemic activities have also been reported. However, the methodologies employed in individual studies are limited. CONCLUSIONS: There is convincing evidence from both in vitro and in vivo studies supporting the traditional use of P. sarmentosum and it is imperative that natural bioactive compounds are examined further. More efforts should be focused on the pharmacodynamic constituents of P. sarmentosum to provide practical basis for quality control, and additional studies are needed to understand the mechanism of their action. Further studies on the comprehensive evaluation of medicinal quality and understandings of serum chemistry, multi-target network pharmacology, and molecular docking technology of P. sarmentosum are of great importance and should be considered. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/32620264/Piper_sarmentosum_Roxb.:_A_review_on_its_botany,_traditional_uses,_phytochemistry,_and_pharmacological_activities L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(19)34365-X DB - PRIME DP - Unbound Medicine ER -
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