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Short-term effects of atropine combined with orthokeratology (ACO) on choroidal thickness.
Cont Lens Anterior Eye. 2020 Jun 30 [Online ahead of print]CL

Abstract

PURPOSE

To analyse the one-month change in subfoveal choroidal thickness (SFChT) of myopic children treated with 0.01 % atropine, orthokeratology (OK), or their combination.

METHODS

This is a prospective, randomized controlled trial. One hundred fifty-four children aged between 8 and 12 years with a spherical equivalent (SE) of -1.00 to -6.00 diopters were enrolled. Subjects were randomly assigned to receive 0.01 % atropine and orthokeratology (ACO, n = 39), 0.01 % atropine and single vision glasses (atropine, n = 42), orthokeratology and placebo (OK, n = 36), or placebo and single vision glasses (control, n = 37). SFChT was assessed using optical coherence tomography (OCT). Ocular parameters, including axial length (AL), were measured using a Lenstar LS 900.

RESULTS

SFChT significantly increased in the ACO (14.12 ± 12.88 μm, p < 0.001), OK (9.43 ± 9.14 μm, p < 0.001) and atropine (5.49 ± 9.38 μm, p < 0.001) groups, while it significantly decreased in the control group (-4.81 ± 9.93 μm, p = 0.006). The one-month change in SFChT was significantly different between the control and treatment groups (p < 0.001). The results of pairwise comparisons among the treatment groups showed that the magnitude of the SFChT change was larger in the ACO group than in the atropine group (p = 0.002). The changes in the ACO and OK groups were not significantly different (p = 0.326).

CONCLUSION

The combination of OK and atropine induced a greater increase in SFChT than monotherapy with atropine, which might indicate a better treatment effect for childhood myopia control.

Authors+Show Affiliations

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China. Electronic address: Yangx_zoc@163.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32620344

Citation

Zhao, Wenchen, et al. "Short-term Effects of Atropine Combined With Orthokeratology (ACO) On Choroidal Thickness." Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association, 2020.
Zhao W, Li Z, Hu Y, et al. Short-term effects of atropine combined with orthokeratology (ACO) on choroidal thickness. Cont Lens Anterior Eye. 2020.
Zhao, W., Li, Z., Hu, Y., Jiang, J., Long, W., Cui, D., Chen, W., & Yang, X. (2020). Short-term effects of atropine combined with orthokeratology (ACO) on choroidal thickness. Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association. https://doi.org/10.1016/j.clae.2020.06.006
Zhao W, et al. Short-term Effects of Atropine Combined With Orthokeratology (ACO) On Choroidal Thickness. Cont Lens Anterior Eye. 2020 Jun 30; PubMed PMID: 32620344.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Short-term effects of atropine combined with orthokeratology (ACO) on choroidal thickness. AU - Zhao,Wenchen, AU - Li,Zhouyue, AU - Hu,Yin, AU - Jiang,Jinyun, AU - Long,Wen, AU - Cui,Dongmei, AU - Chen,Weiyin, AU - Yang,Xiao, Y1 - 2020/06/30/ PY - 2020/01/16/received PY - 2020/06/17/revised PY - 2020/06/18/accepted PY - 2020/7/5/entrez KW - Atropine KW - Choroidal thickness KW - Myopia KW - Orthokeratology JF - Contact lens & anterior eye : the journal of the British Contact Lens Association JO - Cont Lens Anterior Eye N2 - PURPOSE: To analyse the one-month change in subfoveal choroidal thickness (SFChT) of myopic children treated with 0.01 % atropine, orthokeratology (OK), or their combination. METHODS: This is a prospective, randomized controlled trial. One hundred fifty-four children aged between 8 and 12 years with a spherical equivalent (SE) of -1.00 to -6.00 diopters were enrolled. Subjects were randomly assigned to receive 0.01 % atropine and orthokeratology (ACO, n = 39), 0.01 % atropine and single vision glasses (atropine, n = 42), orthokeratology and placebo (OK, n = 36), or placebo and single vision glasses (control, n = 37). SFChT was assessed using optical coherence tomography (OCT). Ocular parameters, including axial length (AL), were measured using a Lenstar LS 900. RESULTS: SFChT significantly increased in the ACO (14.12 ± 12.88 μm, p < 0.001), OK (9.43 ± 9.14 μm, p < 0.001) and atropine (5.49 ± 9.38 μm, p < 0.001) groups, while it significantly decreased in the control group (-4.81 ± 9.93 μm, p = 0.006). The one-month change in SFChT was significantly different between the control and treatment groups (p < 0.001). The results of pairwise comparisons among the treatment groups showed that the magnitude of the SFChT change was larger in the ACO group than in the atropine group (p = 0.002). The changes in the ACO and OK groups were not significantly different (p = 0.326). CONCLUSION: The combination of OK and atropine induced a greater increase in SFChT than monotherapy with atropine, which might indicate a better treatment effect for childhood myopia control. SN - 1476-5411 UR - https://www.unboundmedicine.com/medline/citation/32620344/Short-term_effects_of_atropine_combined_with_orthokeratology_(ACO)_on_choroidal_thickness L2 - https://linkinghub.elsevier.com/retrieve/pii/S1367-0484(20)30118-1 DB - PRIME DP - Unbound Medicine ER -
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