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Impact of CD44 gene single nucleotide polymorphism (rs 13347) in mobilization of autologous HSCT.
Transfus Apher Sci. 2020 Jun 27 [Online ahead of print]TA

Abstract

MOBILIZATION: of stem cells into peripheral blood is a crucial step in the procedure of autologous stem cell transplantation. Mobilization can be affected by many variables;underlying diseases, prior treatment and age. Many genetic polymorphisms mainly in adhesion molecules are thought to affect mobilization success. The CD44 is a cell adhesion molecule which is highly heterogeneous structurally. Polymorphisms in this molecule may impair HSC lodgment in the bone marrow.

THE AIM OF THE WORK

was to assess the impact of CD44 single nucleotide polymorphism (rs13347) on the efficacy of mobilization of CD34+ hematopoietic progenitor cells in a cohort of Egyptian patients treated for lymphoma and multiple myeloma and scheduled for autologous stem cell transplantation.

PATIENTS AND METHODS

the study was conducted on 92 patients scheduled for autologous HSC mobilization and transplantation. SNP genotyping was done by 5 ꞌ nuclease assay on rotor gene.

RESULTS

A statistical significant difference was detected between the patients with genotypes (CT + CC) and patients with (TT) genotype regarding the number of apheresis sessions required to gather the target CD34 count (p = 0.006).T allele is implicated in poorer mobilization.

CONCLUSIONS

CD44 SNPs analysis may be helpful for predicting the poor mobilizers. These patients may benefit from newer modalities like adhesion molecules inhibitors.

Authors+Show Affiliations

Department of Clinical and Chemical Pathology, Faculty of Medicine, Alexandria University, Egypt. Electronic address: neveen.lewis@alexmed.edu.eg.Department of Clinical and Chemical Pathology, Faculty of Medicine, Alexandria University, Egypt.Department of Clinical and Chemical Pathology, Faculty of Medicine, Alexandria University, Egypt.Department of Internal Medicine, Faculty of Medicine, Alexandria University, Egypt.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32620411

Citation

Mikhael, Neveen, et al. "Impact of CD44 Gene Single Nucleotide Polymorphism (rs 13347) in Mobilization of Autologous HSCT." Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis, 2020, p. 102869.
Mikhael N, Mossad A, Ayad M, et al. Impact of CD44 gene single nucleotide polymorphism (rs 13347) in mobilization of autologous HSCT. Transfus Apher Sci. 2020.
Mikhael, N., Mossad, A., Ayad, M., & Nafae, D. (2020). Impact of CD44 gene single nucleotide polymorphism (rs 13347) in mobilization of autologous HSCT. Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis, 102869. https://doi.org/10.1016/j.transci.2020.102869
Mikhael N, et al. Impact of CD44 Gene Single Nucleotide Polymorphism (rs 13347) in Mobilization of Autologous HSCT. Transfus Apher Sci. 2020 Jun 27;102869. PubMed PMID: 32620411.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of CD44 gene single nucleotide polymorphism (rs 13347) in mobilization of autologous HSCT. AU - Mikhael,Neveen, AU - Mossad,Amany, AU - Ayad,Mona, AU - Nafae,Dalia, Y1 - 2020/06/27/ PY - 2019/08/07/received PY - 2020/06/05/revised PY - 2020/06/19/accepted PY - 2020/7/5/entrez KW - Autologous KW - CD44 KW - HSCT KW - Mobilization KW - SNP SP - 102869 EP - 102869 JF - Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis JO - Transfus. Apher. Sci. N2 - : MOBILIZATION: of stem cells into peripheral blood is a crucial step in the procedure of autologous stem cell transplantation. Mobilization can be affected by many variables;underlying diseases, prior treatment and age. Many genetic polymorphisms mainly in adhesion molecules are thought to affect mobilization success. The CD44 is a cell adhesion molecule which is highly heterogeneous structurally. Polymorphisms in this molecule may impair HSC lodgment in the bone marrow. THE AIM OF THE WORK: was to assess the impact of CD44 single nucleotide polymorphism (rs13347) on the efficacy of mobilization of CD34+ hematopoietic progenitor cells in a cohort of Egyptian patients treated for lymphoma and multiple myeloma and scheduled for autologous stem cell transplantation. PATIENTS AND METHODS: the study was conducted on 92 patients scheduled for autologous HSC mobilization and transplantation. SNP genotyping was done by 5 ꞌ nuclease assay on rotor gene. RESULTS: A statistical significant difference was detected between the patients with genotypes (CT + CC) and patients with (TT) genotype regarding the number of apheresis sessions required to gather the target CD34 count (p = 0.006).T allele is implicated in poorer mobilization. CONCLUSIONS: CD44 SNPs analysis may be helpful for predicting the poor mobilizers. These patients may benefit from newer modalities like adhesion molecules inhibitors. SN - 1473-0502 UR - https://www.unboundmedicine.com/medline/citation/32620411/Impact_of_CD44_gene_single_nucleotide_polymorphism_(rs_13347)_in_mobilization_of_autologous_HSCT L2 - https://linkinghub.elsevier.com/retrieve/pii/S1473-0502(20)30174-9 DB - PRIME DP - Unbound Medicine ER -
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