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Association of acute myocardial infarction with seropositive rheumatoid arthritis in Korea: A nationwide longitudinal cohort study.
J Clin Neurosci. 2020 Aug; 78:97-101.JC

Abstract

BACKGROUND

The aim of this nationwide age- and sex matched longitudinal follow up study is to determine the risk of acute myocardial infarction (AMI) associated with the seropositive rheumatoid arthritis (RA) population in Korea.

METHODS

Patient data were collected from the National Health Insurance Service Health Screening cohort. RA was identified using the International Classification of Diseases code M05 (seropositive RA), with a prescription of any disease-modifying anti-rheumatic drug (DMARD). A total of 2,765 patients were enrolled in the seropositive RA group from January 1, 2004 to December 31, 2015 from the NHIS. The control group consisted of 13,825 subjects. The 12-years AMI incidence rate for each group was calculated using the Kaplan-Meier method. A Cox proportional-hazards regression analysis was used to estimate the hazard ratio of AMI.

RESULTS

During the follow-up period, 39 patients (1.41%) in the seropositive RA group and 111 (0.80%) in the control group experienced AMI (P = 0.003). The hazard ratio of AMI in the seropositive RA group was 3.879 (95% confidence interval (CI): 2.64-5.68) after adjusting for age and sex. The adjusted hazard ratio of AMI in the seropositive RA group was 4.212 (95% CI: 2.86-6.19) after adjusting for demographics and comorbid medical disorders. According to subgroup analysis, in male and female and the non-diabetes and non-hypertension and hypertension and dyslipidemia and non-dyslipidemia subgroups, AMI incidence rates were significantly higher in the seropositive RA group than in the control group.

CONCLUSION

Our nationwide longitudinal study suggests an increased risk of AMI in seropositive RA patients.

Authors+Show Affiliations

Department of Neurosurgery, CHA University, CHA Bundang Medical Center, Seongnam, Gyeonggi-do, South Korea.Genome & Health Big Data Branch, Department of Public Health, Graduate School of Public Health, Seoul National University, Seoul, South Korea.Department of Neurosurgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea.Department of Neurosurgery, CHA University, CHA Bundang Medical Center, Seongnam, Gyeonggi-do, South Korea.Department of Neurosurgery, CHA University, CHA Bundang Medical Center, Seongnam, Gyeonggi-do, South Korea.Department of Neurosurgery, CHA University, CHA Bundang Medical Center, Seongnam, Gyeonggi-do, South Korea. Electronic address: sisohn@cha.ac.kr.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32620475

Citation

Lee, Jung-Keun, et al. "Association of Acute Myocardial Infarction With Seropositive Rheumatoid Arthritis in Korea: a Nationwide Longitudinal Cohort Study." Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia, vol. 78, 2020, pp. 97-101.
Lee JK, Kim H, Hong JB, et al. Association of acute myocardial infarction with seropositive rheumatoid arthritis in Korea: A nationwide longitudinal cohort study. J Clin Neurosci. 2020;78:97-101.
Lee, J. K., Kim, H., Hong, J. B., Sheen, S. H., Han, I. B., & Sohn, S. (2020). Association of acute myocardial infarction with seropositive rheumatoid arthritis in Korea: A nationwide longitudinal cohort study. Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia, 78, 97-101. https://doi.org/10.1016/j.jocn.2020.06.002
Lee JK, et al. Association of Acute Myocardial Infarction With Seropositive Rheumatoid Arthritis in Korea: a Nationwide Longitudinal Cohort Study. J Clin Neurosci. 2020;78:97-101. PubMed PMID: 32620475.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of acute myocardial infarction with seropositive rheumatoid arthritis in Korea: A nationwide longitudinal cohort study. AU - Lee,Jung-Keun, AU - Kim,Hakyung, AU - Hong,Je Beom, AU - Sheen,Seung Hun, AU - Han,In-Bo, AU - Sohn,Seil, Y1 - 2020/07/01/ PY - 2020/04/02/received PY - 2020/06/06/accepted PY - 2020/7/6/pubmed PY - 2020/7/6/medline PY - 2020/7/5/entrez KW - Epidemiology KW - Myocardial infarction KW - Population KW - Rheumatoid arthritis SP - 97 EP - 101 JF - Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia JO - J Clin Neurosci VL - 78 N2 - BACKGROUND: The aim of this nationwide age- and sex matched longitudinal follow up study is to determine the risk of acute myocardial infarction (AMI) associated with the seropositive rheumatoid arthritis (RA) population in Korea. METHODS: Patient data were collected from the National Health Insurance Service Health Screening cohort. RA was identified using the International Classification of Diseases code M05 (seropositive RA), with a prescription of any disease-modifying anti-rheumatic drug (DMARD). A total of 2,765 patients were enrolled in the seropositive RA group from January 1, 2004 to December 31, 2015 from the NHIS. The control group consisted of 13,825 subjects. The 12-years AMI incidence rate for each group was calculated using the Kaplan-Meier method. A Cox proportional-hazards regression analysis was used to estimate the hazard ratio of AMI. RESULTS: During the follow-up period, 39 patients (1.41%) in the seropositive RA group and 111 (0.80%) in the control group experienced AMI (P = 0.003). The hazard ratio of AMI in the seropositive RA group was 3.879 (95% confidence interval (CI): 2.64-5.68) after adjusting for age and sex. The adjusted hazard ratio of AMI in the seropositive RA group was 4.212 (95% CI: 2.86-6.19) after adjusting for demographics and comorbid medical disorders. According to subgroup analysis, in male and female and the non-diabetes and non-hypertension and hypertension and dyslipidemia and non-dyslipidemia subgroups, AMI incidence rates were significantly higher in the seropositive RA group than in the control group. CONCLUSION: Our nationwide longitudinal study suggests an increased risk of AMI in seropositive RA patients. SN - 1532-2653 UR - https://www.unboundmedicine.com/medline/citation/32620475/Association_of_acute_myocardial_infarction_with_seropositive_rheumatoid_arthritis_in_Korea:_A_nationwide_longitudinal_cohort_study L2 - https://linkinghub.elsevier.com/retrieve/pii/S0967-5868(20)31310-2 DB - PRIME DP - Unbound Medicine ER -
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