Tags

Type your tag names separated by a space and hit enter

Cutaneous undifferentiated pleomorphic sarcoma is a pleomorphic dermal sarcoma.
Dermatol Online J. 2020 May 15; 26(5)DO

Abstract

Pleomorphic dermal sarcoma is a cutaneous soft tissue sarcoma that presents as a rapidly enlarging tumor, typically on a sun-exposed location of elderly individuals. The neoplasm shares many similar features - clinical, pathologic, immunohistochemical and genomic - with atypical fibroxanthoma. However, adverse histologic characteristics (deep subcutaneous invasion, tumor necrosis, lymphovascular invasion, and/or perineural invasion) differentiate pleomorphic dermal sarcoma from atypical fibroxanthoma and may account for the more aggressive biologic behavior of pleomorphic dermal sarcoma: local recurrence and metastases. The features of a woman with pleomorphic dermal sarcoma are described. Her sarcoma presented as a rapidly growing ulcerated red nodule on the left side of her face. Imaging studies were performed prior to surgery. The tumor was extirpated with a wide local excision and she received postoperative radiotherapy. There has been no recurrence or metastasis at one-year follow-up. Pleomorphic dermal sarcoma has previously been referred to as a malignant fibrous histiocytoma (until the term became antiquated) and an undifferentiated pleomorphic sarcoma. However, the latter term includes not only neoplasms from the skin but also sarcomas from internal organs, retroperitoneal and osteoid origin. Therefore, when classifying this undifferentiated soft tissue sarcomas of cutaneous origin, the term pleomorphic dermal sarcoma may be preferred.

Authors+Show Affiliations

San Diego Family Dermatology, National City, CA Touro University California College of Osteopathic Medicine, Vallejo, CA Scripps Family Medicine Residency, Scripps Mercy Hospital Chula Vista, Chula Vista, CA Family Medicine Residency, Family Health Centers of San Diego, San Diego, CA. mitehead@gmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32621710

Citation

Cohen, Philip R.. "Cutaneous Undifferentiated Pleomorphic Sarcoma Is a Pleomorphic Dermal Sarcoma." Dermatology Online Journal, vol. 26, no. 5, 2020.
Cohen PR. Cutaneous undifferentiated pleomorphic sarcoma is a pleomorphic dermal sarcoma. Dermatol Online J. 2020;26(5).
Cohen, P. R. (2020). Cutaneous undifferentiated pleomorphic sarcoma is a pleomorphic dermal sarcoma. Dermatology Online Journal, 26(5).
Cohen PR. Cutaneous Undifferentiated Pleomorphic Sarcoma Is a Pleomorphic Dermal Sarcoma. Dermatol Online J. 2020 May 15;26(5) PubMed PMID: 32621710.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cutaneous undifferentiated pleomorphic sarcoma is a pleomorphic dermal sarcoma. A1 - Cohen,Philip R, Y1 - 2020/05/15/ PY - 2020/06/16/received PY - 2020/06/16/accepted PY - 2020/7/5/entrez PY - 2020/7/6/pubmed PY - 2020/7/6/medline JF - Dermatology online journal JO - Dermatol. Online J. VL - 26 IS - 5 N2 - Pleomorphic dermal sarcoma is a cutaneous soft tissue sarcoma that presents as a rapidly enlarging tumor, typically on a sun-exposed location of elderly individuals. The neoplasm shares many similar features - clinical, pathologic, immunohistochemical and genomic - with atypical fibroxanthoma. However, adverse histologic characteristics (deep subcutaneous invasion, tumor necrosis, lymphovascular invasion, and/or perineural invasion) differentiate pleomorphic dermal sarcoma from atypical fibroxanthoma and may account for the more aggressive biologic behavior of pleomorphic dermal sarcoma: local recurrence and metastases. The features of a woman with pleomorphic dermal sarcoma are described. Her sarcoma presented as a rapidly growing ulcerated red nodule on the left side of her face. Imaging studies were performed prior to surgery. The tumor was extirpated with a wide local excision and she received postoperative radiotherapy. There has been no recurrence or metastasis at one-year follow-up. Pleomorphic dermal sarcoma has previously been referred to as a malignant fibrous histiocytoma (until the term became antiquated) and an undifferentiated pleomorphic sarcoma. However, the latter term includes not only neoplasms from the skin but also sarcomas from internal organs, retroperitoneal and osteoid origin. Therefore, when classifying this undifferentiated soft tissue sarcomas of cutaneous origin, the term pleomorphic dermal sarcoma may be preferred. SN - 1087-2108 UR - https://www.unboundmedicine.com/medline/citation/32621710/Cutaneous_undifferentiated_pleomorphic_sarcoma_is_a_pleomorphic_dermal_sarcoma L2 - http://escholarship.org/uc/item/1tx8b3hr DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.