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Bilirubin in metabolic syndrome and associated inflammatory diseases: New perspectives.
Life Sci. 2020 Jul 01; 257:118032.LS

Abstract

Diabetes mellitus is one of the major global health issues, which is closely related to metabolic dysfunction and the chronic inflammatory diseases. Multiple studies have demonstrated that serum bilirubin is negatively correlated with metabolic syndrome and associated inflammatory diseases, including atherosclerosis, hypertension, etc. However, the roles of bilirubin in metabolic syndrome and associated inflammatory diseases still remain unclear. Here, we explain the role of bilirubin in metabolic syndrome and chronic inflammatory diseases and its therapeutic potential. Understanding the role of bilirubin activities in diabetes may serve as a therapeutic target for the treatment of chronic inflammatory diseases in diabetic patients.

Authors+Show Affiliations

Guangxi Key Laboratory of Diabetic Systems Medicine, Guilin Medical University, Guilin 541000, Guangxi, China.International College, University of South China, Hengyang, Hunan Province 421001, China.The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan City People's Hospital, Qingyuan, Guangdong 511518, China. Electronic address: zhaoguojun@gzhmu.edu.cn.Guangxi Key Laboratory of Diabetic Systems Medicine, Guilin Medical University, Guilin 541000, Guangxi, China; The Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi 541100, China. Electronic address: kaiyinby@qq.com.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32621920

Citation

Novák, Petr, et al. "Bilirubin in Metabolic Syndrome and Associated Inflammatory Diseases: New Perspectives." Life Sciences, vol. 257, 2020, p. 118032.
Novák P, Jackson AO, Zhao GJ, et al. Bilirubin in metabolic syndrome and associated inflammatory diseases: New perspectives. Life Sci. 2020;257:118032.
Novák, P., Jackson, A. O., Zhao, G. J., & Yin, K. (2020). Bilirubin in metabolic syndrome and associated inflammatory diseases: New perspectives. Life Sciences, 257, 118032. https://doi.org/10.1016/j.lfs.2020.118032
Novák P, et al. Bilirubin in Metabolic Syndrome and Associated Inflammatory Diseases: New Perspectives. Life Sci. 2020 Jul 1;257:118032. PubMed PMID: 32621920.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bilirubin in metabolic syndrome and associated inflammatory diseases: New perspectives. AU - Novák,Petr, AU - Jackson,Ampadu O, AU - Zhao,Guo-Jun, AU - Yin,Kai, Y1 - 2020/07/01/ PY - 2020/7/6/pubmed PY - 2020/7/6/medline PY - 2020/7/5/entrez KW - Bilirubin KW - Diabetes KW - Hyperbilirubinemia KW - Metabolic syndrome SP - 118032 EP - 118032 JF - Life sciences JO - Life Sci. VL - 257 N2 - Diabetes mellitus is one of the major global health issues, which is closely related to metabolic dysfunction and the chronic inflammatory diseases. Multiple studies have demonstrated that serum bilirubin is negatively correlated with metabolic syndrome and associated inflammatory diseases, including atherosclerosis, hypertension, etc. However, the roles of bilirubin in metabolic syndrome and associated inflammatory diseases still remain unclear. Here, we explain the role of bilirubin in metabolic syndrome and chronic inflammatory diseases and its therapeutic potential. Understanding the role of bilirubin activities in diabetes may serve as a therapeutic target for the treatment of chronic inflammatory diseases in diabetic patients. SN - 1879-0631 UR - https://www.unboundmedicine.com/medline/citation/32621920/Bilirubin_in_metabolic_syndrome_and_associated_inflammatory_diseases:_New_perspectives L2 - https://linkinghub.elsevier.com/retrieve/pii/S0024-3205(20)30782-7 DB - PRIME DP - Unbound Medicine ER -
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