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Ancestral origin, antigenic resemblance and epidemiological insights of novel coronavirus (SARS-CoV-2): Global burden and Bangladesh perspective.
Infect Genet Evol. 2020 Oct; 84:104440.IG

Abstract

SARS-CoV-2, a new coronavirus strain responsible for COVID-19, has emerged in Wuhan City, China, and continuing its global pandemic nature. The availability of the complete gene sequences of the virus helps to know about the origin and molecular characteristics of this virus. In the present study, we performed bioinformatic analysis of the available gene sequence data of SARS-CoV-2 for the understanding of evolution and molecular characteristics and immunogenic resemblance of the circulating viruses. Phylogenetic analysis was performed for four types of representative viral proteins (spike, membrane, envelope and nucleoprotein) of SARS-CoV-2, HCoV-229E, HCoV-OC43, SARS-CoV, HCoV-NL63, HKU1, MERS-CoV, HKU4, HKU5 and BufCoV-HKU26. The findings demonstrated that SARS-CoV-2 exhibited convergent evolutionary relation with previously reported SARS-CoV. It was also depicted that SARS-CoV-2 proteins were highly similar and identical to SARS-CoV proteins, though proteins from other coronaviruses showed a lower level of resemblance. The cross-checked conservancy analysis of SARS-CoV-2 antigenic epitopes showed significant conservancy with antigenic epitopes derived from SARS-CoV. Descriptive epidemiological analysis on several epidemiological indices was performed on available epidemiological outbreak information from several open databases on COVID-19 (SARS-CoV-2). Satellite-derived imaging data have been employed to understand the role of temperature in the environmental persistence of the virus. Findings of the descriptive analysis were used to describe the global impact of newly emerged SARS-CoV-2, and the risk of an epidemic in Bangladesh.

Authors+Show Affiliations

Department of Medicine, Sylhet Agricultural University, Sylhet-3100, Bangladesh. Electronic address: bashir.vetmed@sau.ac.bd.Department of Pharmaceuticals and Industrial Biotechnology, Sylhet Agricultural University, Sylhet-3100, Bangladesh.Department of Aquatic Resource Management, Sylhet Agricultural University, Sylhet-3100, Bangladesh.Department of Epidemiology and Public Health, Sylhet Agricultural University, Sylhet-3100, Bangladesh.Department of Pharmaceuticals and Industrial Biotechnology, Sylhet Agricultural University, Sylhet-3100, Bangladesh.Department of Epidemiology and Public Health, Sylhet Agricultural University, Sylhet-3100, Bangladesh. Electronic address: ahmedssu.eph@sau.ac.bd.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32622082

Citation

Uddin, Md Bashir, et al. "Ancestral Origin, Antigenic Resemblance and Epidemiological Insights of Novel Coronavirus (SARS-CoV-2): Global Burden and Bangladesh Perspective." Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases, vol. 84, 2020, p. 104440.
Uddin MB, Hasan M, Harun-Al-Rashid A, et al. Ancestral origin, antigenic resemblance and epidemiological insights of novel coronavirus (SARS-CoV-2): Global burden and Bangladesh perspective. Infect Genet Evol. 2020;84:104440.
Uddin, M. B., Hasan, M., Harun-Al-Rashid, A., Ahsan, M. I., Imran, M. A. S., & Ahmed, S. S. U. (2020). Ancestral origin, antigenic resemblance and epidemiological insights of novel coronavirus (SARS-CoV-2): Global burden and Bangladesh perspective. Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases, 84, 104440. https://doi.org/10.1016/j.meegid.2020.104440
Uddin MB, et al. Ancestral Origin, Antigenic Resemblance and Epidemiological Insights of Novel Coronavirus (SARS-CoV-2): Global Burden and Bangladesh Perspective. Infect Genet Evol. 2020;84:104440. PubMed PMID: 32622082.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ancestral origin, antigenic resemblance and epidemiological insights of novel coronavirus (SARS-CoV-2): Global burden and Bangladesh perspective. AU - Uddin,Md Bashir, AU - Hasan,Mahmudul, AU - Harun-Al-Rashid,Ahmed, AU - Ahsan,Md Irtija, AU - Imran,Md Abdus Shukur, AU - Ahmed,Syed Sayeem Uddin, Y1 - 2020/07/01/ PY - 2020/05/08/received PY - 2020/06/19/revised PY - 2020/06/21/accepted PY - 2020/7/6/pubmed PY - 2020/10/3/medline PY - 2020/7/5/entrez KW - Bangladesh KW - Descriptive epidemiology KW - Evolutionary analysis KW - Pandemic KW - SARS-CoV-2 KW - Temperature SP - 104440 EP - 104440 JF - Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases JO - Infect Genet Evol VL - 84 N2 - SARS-CoV-2, a new coronavirus strain responsible for COVID-19, has emerged in Wuhan City, China, and continuing its global pandemic nature. The availability of the complete gene sequences of the virus helps to know about the origin and molecular characteristics of this virus. In the present study, we performed bioinformatic analysis of the available gene sequence data of SARS-CoV-2 for the understanding of evolution and molecular characteristics and immunogenic resemblance of the circulating viruses. Phylogenetic analysis was performed for four types of representative viral proteins (spike, membrane, envelope and nucleoprotein) of SARS-CoV-2, HCoV-229E, HCoV-OC43, SARS-CoV, HCoV-NL63, HKU1, MERS-CoV, HKU4, HKU5 and BufCoV-HKU26. The findings demonstrated that SARS-CoV-2 exhibited convergent evolutionary relation with previously reported SARS-CoV. It was also depicted that SARS-CoV-2 proteins were highly similar and identical to SARS-CoV proteins, though proteins from other coronaviruses showed a lower level of resemblance. The cross-checked conservancy analysis of SARS-CoV-2 antigenic epitopes showed significant conservancy with antigenic epitopes derived from SARS-CoV. Descriptive epidemiological analysis on several epidemiological indices was performed on available epidemiological outbreak information from several open databases on COVID-19 (SARS-CoV-2). Satellite-derived imaging data have been employed to understand the role of temperature in the environmental persistence of the virus. Findings of the descriptive analysis were used to describe the global impact of newly emerged SARS-CoV-2, and the risk of an epidemic in Bangladesh. SN - 1567-7257 UR - https://www.unboundmedicine.com/medline/citation/32622082/Ancestral_origin_antigenic_resemblance_and_epidemiological_insights_of_novel_coronavirus__SARS_CoV_2_:_Global_burden_and_Bangladesh_perspective_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1567-1348(20)30271-9 DB - PRIME DP - Unbound Medicine ER -