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Association between reduced heart rate variability components and supraventricular tachyarrhythmias in patients with a systemic right ventricle.
Auton Neurosci. 2020 09; 227:102696.AN

Abstract

BACKGROUND

Patients with a systemic right ventricle are prone to develop heart failure. Abnormal heart rate variability (HRV), a measure of autonomic dysfunction, is associated with morbidity and mortality in patients with left ventricular failure. The association between HRV and supraventricular arrhythmias (SVTs), which are associated with adverse events in this population, was assessed.

METHODS

24-Hour Holter recordings of patients with a systemic right ventricle and healthy controls were analysed in a retrospective cohort study. HRV was calculated and compared between groups. Correlation coefficients were determined for HRV variables and clinical characteristics. The relation between HRV and SVTs was investigated with linear regression.

RESULTS

The patient group included 29 patients (69%) late after Mustard or Senning correction for transposition of the great arteries, and 13 patients with congenitally corrected transposition of the great arteries (31%). The control group included 38 subjects. HRV was significantly lower in patients compared with controls. In the patient group, lower SDANN (standard deviation of the average NN intervals calculated over 5-minute intervals) was independently associated with a higher number of supraventricular arrhythmias (95% CI -0.03 to -0.0004, p = 0.045). In exploratory correlation analysis, several HRV variables correlated with echocardiographic systemic right ventricular function (rho = 0.36, p = 0.02 for SDANN), and exercise capacity (rho = 0.39, p = 0.05 for SDANN).

CONCLUSION

In patients with a systemic right ventricle, HRV is lower compared with controls and (SDANN) is independently associated with supraventricular arrhythmias.

Authors+Show Affiliations

Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: T.e.zandstra@lumc.nl.Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: P.kies@lumc.nl.Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: ariemaan@gmail.com.Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: S.man@lumc.nl.Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: M.Bootsma@lumc.nl.Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: H.w.vliegen@lumc.nl.Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: A.egorova@lumc.nl.Department of Statistics, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: B.j.a.mertens@lumc.nl.Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: E.r.holman@lumc.nl.Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: M.j.schalij@lumc.nl.Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands; Department of Anatomy & Embryology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: M.r.m.jongbloed@lumc.nl.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32623323

Citation

Zandstra, Tjitske, et al. "Association Between Reduced Heart Rate Variability Components and Supraventricular Tachyarrhythmias in Patients With a Systemic Right Ventricle." Autonomic Neuroscience : Basic & Clinical, vol. 227, 2020, p. 102696.
Zandstra T, Kiès P, Maan A, et al. Association between reduced heart rate variability components and supraventricular tachyarrhythmias in patients with a systemic right ventricle. Auton Neurosci. 2020;227:102696.
Zandstra, T., Kiès, P., Maan, A., Man, S. C., Bootsma, M., Vliegen, H., Egorova, A., Mertens, B., Holman, E., Schalij, M., & Jongbloed, M. (2020). Association between reduced heart rate variability components and supraventricular tachyarrhythmias in patients with a systemic right ventricle. Autonomic Neuroscience : Basic & Clinical, 227, 102696. https://doi.org/10.1016/j.autneu.2020.102696
Zandstra T, et al. Association Between Reduced Heart Rate Variability Components and Supraventricular Tachyarrhythmias in Patients With a Systemic Right Ventricle. Auton Neurosci. 2020;227:102696. PubMed PMID: 32623323.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between reduced heart rate variability components and supraventricular tachyarrhythmias in patients with a systemic right ventricle. AU - Zandstra,Tjitske, AU - Kiès,Philippine, AU - Maan,Arie, AU - Man,Sum-Che, AU - Bootsma,Marianne, AU - Vliegen,Hubert, AU - Egorova,Anastasia, AU - Mertens,Bart, AU - Holman,Eduard, AU - Schalij,Martin, AU - Jongbloed,Monique, Y1 - 2020/06/26/ PY - 2019/09/16/received PY - 2020/05/24/revised PY - 2020/06/23/accepted PY - 2020/7/6/pubmed PY - 2020/7/6/medline PY - 2020/7/6/entrez KW - Cardiac arrhythmia KW - Heart failure KW - Parasympathetic nervous system KW - Sympathetic nervous system KW - Transposition of great vessels SP - 102696 EP - 102696 JF - Autonomic neuroscience : basic & clinical JO - Auton Neurosci VL - 227 N2 - BACKGROUND: Patients with a systemic right ventricle are prone to develop heart failure. Abnormal heart rate variability (HRV), a measure of autonomic dysfunction, is associated with morbidity and mortality in patients with left ventricular failure. The association between HRV and supraventricular arrhythmias (SVTs), which are associated with adverse events in this population, was assessed. METHODS: 24-Hour Holter recordings of patients with a systemic right ventricle and healthy controls were analysed in a retrospective cohort study. HRV was calculated and compared between groups. Correlation coefficients were determined for HRV variables and clinical characteristics. The relation between HRV and SVTs was investigated with linear regression. RESULTS: The patient group included 29 patients (69%) late after Mustard or Senning correction for transposition of the great arteries, and 13 patients with congenitally corrected transposition of the great arteries (31%). The control group included 38 subjects. HRV was significantly lower in patients compared with controls. In the patient group, lower SDANN (standard deviation of the average NN intervals calculated over 5-minute intervals) was independently associated with a higher number of supraventricular arrhythmias (95% CI -0.03 to -0.0004, p = 0.045). In exploratory correlation analysis, several HRV variables correlated with echocardiographic systemic right ventricular function (rho = 0.36, p = 0.02 for SDANN), and exercise capacity (rho = 0.39, p = 0.05 for SDANN). CONCLUSION: In patients with a systemic right ventricle, HRV is lower compared with controls and (SDANN) is independently associated with supraventricular arrhythmias. SN - 1872-7484 UR - https://www.unboundmedicine.com/medline/citation/32623323/Association_between_reduced_heart_rate_variability_components_and_supraventricular_tachyarrhythmias_in_patients_with_a_systemic_right_ventricle L2 - https://linkinghub.elsevier.com/retrieve/pii/S1566-0702(20)30130-2 DB - PRIME DP - Unbound Medicine ER -
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