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The Relationship Between Alcohol Consumption with Vascular Structure and Arterial Stiffness in the Spanish Population. EVA Study.
Alcohol Clin Exp Res. 2020 Jul 05 [Online ahead of print]AC

Abstract

BACKGROUND

Controversy exists regarding the way alcohol use is associated with vascular structure and arterial stiffness parameters. The purpose of this study is to evaluate the association between alcohol consumption with vascular structure and arterial stiffness in an adult population.

METHODS

We conducted a cross-sectional study. Five hundred and one participants were recruited by random sampling from an urban population of 43946 individuals aged 35 to 75 years, assigned from five health care centers located in Salamanca, Spain. This was a subanalysis of the EVA study. Arterial stiffness was assessed by measuring Cardio-ankle vascular index (CAVI) and brachial-ankle pulse wave velocity (ba-PWV) with the VaSera VS-1500® device, and carotid-femoral pulse wave velocity (cf-PWV) with the Sphygmocor®. Vascular structure was evaluated by measuring the carotid intima-media thickness (c-IMT) with a Sonosite Micromax® ultrasound. Alcohol consumption was calculated using a standardized questionnaire and quantified in g/week.

RESULTS

In the multiple regression analysis adjusted for sex, age, smoking status and systolic blood pressure, the c-IMT and cf-PWV values of individuals drinking > 70 g/week were higher than those of the reference group (non-drinkers) by 0.02 mm (p = 0.030) and 0.42 m/sec (p = 0.021) respectively. The association between alcohol consumption with vascular structure and arterial stiffness, only attains statistical significance for cf-PWV (p = 0.039) and c-IMT (p = 0.019), showing an association which suggests a J-shaped association. This association was not statistically significant for ba-PWV and CAVI (p=0.446 and p=0.141 respectively), although a similar trend was observed with ba-PWV.

CONCLUSIONS

The results of this study suggest that heavy alcohol consumption (>70 g/week) is associated with increased c-IMT and cf-PWV. Moreover, we found a J-shaped association between alcohol consumption and c-IMT and cf-PWV values as markers of vascular structure and arterial stiffness, with no association with ba-PWV and CAVI being observed.

Authors+Show Affiliations

Primary Care Research Unit of Salamanca (APISAL), Biomedical Research Institute of Salamanca (IBSAL), 37005, Salamanca, Spain. Department of Nursing and Physiotherapy, University of Salamanca, 37007, Salamanca, Spain.Primary Care Research Unit of Salamanca (APISAL), Biomedical Research Institute of Salamanca (IBSAL), 37005, Salamanca, Spain. Department of Biomedical and Diagnostic Sciences, University of Salamanca, 37007, Salamanca, Spain. Iberian network on arterial structure, central hemodynamics and neurocognition.Primary Care Research Unit of Salamanca (APISAL), Biomedical Research Institute of Salamanca (IBSAL), 37005, Salamanca, Spain. Iberian network on arterial structure, central hemodynamics and neurocognition. Department of Medicine, University of Salamanca, 37007, Salamanca, Spain.Primary Care Research Unit of Salamanca (APISAL), Biomedical Research Institute of Salamanca (IBSAL), 37005, Salamanca, Spain.Primary Care Research Unit of Salamanca (APISAL), Biomedical Research Institute of Salamanca (IBSAL), 37005, Salamanca, Spain.Primary Care Research Unit of Salamanca (APISAL), Biomedical Research Institute of Salamanca (IBSAL), 37005, Salamanca, Spain.Primary Care Research Unit of Salamanca (APISAL), Biomedical Research Institute of Salamanca (IBSAL), 37005, Salamanca, Spain. Department of Nursing and Physiotherapy, University of Salamanca, 37007, Salamanca, Spain.Primary Care Research Unit of Salamanca (APISAL), Biomedical Research Institute of Salamanca (IBSAL), 37005, Salamanca, Spain. Iberian network on arterial structure, central hemodynamics and neurocognition. Department of Medicine, University of Salamanca, 37007, Salamanca, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32623750

Citation

Gonzalez-Sanchez, Jesus, et al. "The Relationship Between Alcohol Consumption With Vascular Structure and Arterial Stiffness in the Spanish Population. EVA Study." Alcoholism, Clinical and Experimental Research, 2020.
Gonzalez-Sanchez J, Garcia-Ortiz L, Rodriguez-Sanchez E, et al. The Relationship Between Alcohol Consumption with Vascular Structure and Arterial Stiffness in the Spanish Population. EVA Study. Alcohol Clin Exp Res. 2020.
Gonzalez-Sanchez, J., Garcia-Ortiz, L., Rodriguez-Sanchez, E., Maderuelo-Fernandez, J. A., Tamayo-Morales, O., Lugones-Sanchez, C., Recio-Rodriguez, J. I., Gomez-Marcos, M. A., Perez, M. B., de Cabo-Laso, A., Aguadero, N. S., González-Porras, J. R., & Bastida-Bermejo, J. M. (2020). The Relationship Between Alcohol Consumption with Vascular Structure and Arterial Stiffness in the Spanish Population. EVA Study. Alcoholism, Clinical and Experimental Research. https://doi.org/10.1111/acer.14411
Gonzalez-Sanchez J, et al. The Relationship Between Alcohol Consumption With Vascular Structure and Arterial Stiffness in the Spanish Population. EVA Study. Alcohol Clin Exp Res. 2020 Jul 5; PubMed PMID: 32623750.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Relationship Between Alcohol Consumption with Vascular Structure and Arterial Stiffness in the Spanish Population. EVA Study. AU - Gonzalez-Sanchez,Jesus, AU - Garcia-Ortiz,Luis, AU - Rodriguez-Sanchez,Emiliano, AU - Maderuelo-Fernandez,Jose A, AU - Tamayo-Morales,Olaya, AU - Lugones-Sanchez,Cristina, AU - Recio-Rodriguez,Jose I, AU - Gomez-Marcos,Manuel A, AU - ,, AU - Perez,Manuel Barreiro, AU - de Cabo-Laso,Angela, AU - Aguadero,Natalia Sanchez, AU - González-Porras,José Ramón, AU - Bastida-Bermejo,José María, Y1 - 2020/07/05/ PY - 2020/7/6/entrez PY - 2020/7/6/pubmed PY - 2020/7/6/medline KW - Alcohol consumption KW - arterial stiffness KW - intima-media thickness KW - pulse wave velocity KW - vascular structure JF - Alcoholism, clinical and experimental research JO - Alcohol. Clin. Exp. Res. N2 - BACKGROUND: Controversy exists regarding the way alcohol use is associated with vascular structure and arterial stiffness parameters. The purpose of this study is to evaluate the association between alcohol consumption with vascular structure and arterial stiffness in an adult population. METHODS: We conducted a cross-sectional study. Five hundred and one participants were recruited by random sampling from an urban population of 43946 individuals aged 35 to 75 years, assigned from five health care centers located in Salamanca, Spain. This was a subanalysis of the EVA study. Arterial stiffness was assessed by measuring Cardio-ankle vascular index (CAVI) and brachial-ankle pulse wave velocity (ba-PWV) with the VaSera VS-1500® device, and carotid-femoral pulse wave velocity (cf-PWV) with the Sphygmocor®. Vascular structure was evaluated by measuring the carotid intima-media thickness (c-IMT) with a Sonosite Micromax® ultrasound. Alcohol consumption was calculated using a standardized questionnaire and quantified in g/week. RESULTS: In the multiple regression analysis adjusted for sex, age, smoking status and systolic blood pressure, the c-IMT and cf-PWV values of individuals drinking > 70 g/week were higher than those of the reference group (non-drinkers) by 0.02 mm (p = 0.030) and 0.42 m/sec (p = 0.021) respectively. The association between alcohol consumption with vascular structure and arterial stiffness, only attains statistical significance for cf-PWV (p = 0.039) and c-IMT (p = 0.019), showing an association which suggests a J-shaped association. This association was not statistically significant for ba-PWV and CAVI (p=0.446 and p=0.141 respectively), although a similar trend was observed with ba-PWV. CONCLUSIONS: The results of this study suggest that heavy alcohol consumption (>70 g/week) is associated with increased c-IMT and cf-PWV. Moreover, we found a J-shaped association between alcohol consumption and c-IMT and cf-PWV values as markers of vascular structure and arterial stiffness, with no association with ba-PWV and CAVI being observed. SN - 1530-0277 UR - https://www.unboundmedicine.com/medline/citation/32623750/The_Relationship_Between_Alcohol_Consumption_with_Vascular_Structure_and_Arterial_Stiffness_in_the_Spanish_Population._EVA_Study L2 - https://doi.org/10.1111/acer.14411 DB - PRIME DP - Unbound Medicine ER -