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Equivalence of in vitro and in vivo methods for assessing the effectiveness of anti-particulate matter pollution products.
Skin Res Technol. 2020 Jul 05 [Online ahead of print]SR

Abstract

BACKGROUND

The in vivo evaluation of antipollution products has attracted attention due to increasing global pollution levels; however, it is expensive, time-consuming, and dangerous because of the harmful nature of fine dust. Therefore, this paper proposes an alternative in vitro assessment method and compares the fine dust blocking effectiveness of both methods for different antipollution products.

MATERIALS AND METHODS

Initially, tests were conducted by spraying fine dust on human forearms and artificial leather without pretreatment for in vivo and in vitro samples, respectively. However, the same results were not obtained for both the methods. Therefore, we evaluated different leather conditions (color, drying time, and temperature) to determine the optimal artificial material for testing antipollution products before adopting beige artificial leather dried at 32°C for 30 minutes for further tests.

RESULTS

The initial tests exhibited a significant difference (P < .05) between the two methods; however, the revised tests exhibited no significant difference (P > .05) between the two methods for either beige leather dried at room temperature (20°C-25°C) for 60 minutes or at 32°C for 30-60 minutes or white leather dried at 32°C for 60 min. Therefore, the in vitro method was deemed equivalent to the in vivo method. The effectiveness of fine dust blocking (P < .05) and the equivalence between the evaluation methods (P > .05) were confirmed for each antipollution product.

CONCLUSION

The proposed method is economical, efficient, and safe, making it a novel and valid alternative for the evaluation of antipollution products.

Authors+Show Affiliations

AMOREPACIFIC R&D Center, Yongin-si, Korea.AMOREPACIFIC R&D Center, Yongin-si, Korea.AMOREPACIFIC R&D Center, Yongin-si, Korea.P&K Skin Research Center, Seoul, Korea.AMOREPACIFIC R&D Center, Yongin-si, Korea.AMOREPACIFIC R&D Center, Yongin-si, Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32623754

Citation

Kim, Sanghun, et al. "Equivalence of in Vitro and in Vivo Methods for Assessing the Effectiveness of Anti-particulate Matter Pollution Products." Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 2020.
Kim S, Kim S, Shon D, et al. Equivalence of in vitro and in vivo methods for assessing the effectiveness of anti-particulate matter pollution products. Skin Res Technol. 2020.
Kim, S., Kim, S., Shon, D., Kim, A. R., Kim, H. J., & Kim, E. (2020). Equivalence of in vitro and in vivo methods for assessing the effectiveness of anti-particulate matter pollution products. Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI). https://doi.org/10.1111/srt.12907
Kim S, et al. Equivalence of in Vitro and in Vivo Methods for Assessing the Effectiveness of Anti-particulate Matter Pollution Products. Skin Res Technol. 2020 Jul 5; PubMed PMID: 32623754.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Equivalence of in vitro and in vivo methods for assessing the effectiveness of anti-particulate matter pollution products. AU - Kim,Sanghun, AU - Kim,Sanghoon, AU - Shon,Dajung, AU - Kim,A Reum, AU - Kim,Hyoung-June, AU - Kim,Eunjoo, Y1 - 2020/07/05/ PY - 2020/04/12/received PY - 2020/06/09/accepted PY - 2020/7/6/entrez PY - 2020/7/6/pubmed PY - 2020/7/6/medline KW - antipollution product testing KW - artificial leather method KW - fine dust blocking KW - human health KW - particulate matter KW - skin protection KW - skin simulation JF - Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) JO - Skin Res Technol N2 - BACKGROUND: The in vivo evaluation of antipollution products has attracted attention due to increasing global pollution levels; however, it is expensive, time-consuming, and dangerous because of the harmful nature of fine dust. Therefore, this paper proposes an alternative in vitro assessment method and compares the fine dust blocking effectiveness of both methods for different antipollution products. MATERIALS AND METHODS: Initially, tests were conducted by spraying fine dust on human forearms and artificial leather without pretreatment for in vivo and in vitro samples, respectively. However, the same results were not obtained for both the methods. Therefore, we evaluated different leather conditions (color, drying time, and temperature) to determine the optimal artificial material for testing antipollution products before adopting beige artificial leather dried at 32°C for 30 minutes for further tests. RESULTS: The initial tests exhibited a significant difference (P < .05) between the two methods; however, the revised tests exhibited no significant difference (P > .05) between the two methods for either beige leather dried at room temperature (20°C-25°C) for 60 minutes or at 32°C for 30-60 minutes or white leather dried at 32°C for 60 min. Therefore, the in vitro method was deemed equivalent to the in vivo method. The effectiveness of fine dust blocking (P < .05) and the equivalence between the evaluation methods (P > .05) were confirmed for each antipollution product. CONCLUSION: The proposed method is economical, efficient, and safe, making it a novel and valid alternative for the evaluation of antipollution products. SN - 1600-0846 UR - https://www.unboundmedicine.com/medline/citation/32623754/Equivalence_of_in_vitro_and_in_vivo_methods_for_assessing_the_effectiveness_of_anti-particulate_matter_pollution_products L2 - https://doi.org/10.1111/srt.12907 DB - PRIME DP - Unbound Medicine ER -
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