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[Study on difference of chemical compositions of Guilingji before and after alchemy based on mass spectrometry and multivariate statistical analysis].
Zhongguo Zhong Yao Za Zhi. 2020 Jun; 45(12):2872-2880.ZZ

Abstract

UPLC-Q-Orbitrap MS/MS and ICP-MS coupled with multivariate statistical analysis was employed to explore the differences in chemical compositions of Guilingji(GLJ) before and after alchemy.The changes in organic chemical compositions and inorganic elements were observed and 39 differential organic compositions were found in GLJ after alchemy, 24 compounds of which were identified. The differential compositions of GLJ included violet ketones, chalcones, amides, and fatty acids whose contents were increased after alchemy, as well as flavones, isoflavones, dihydroflavones, flavonoid glycosides, and coumarins whose content were decreased after alchemy. This study showed 6 inorganic elements filtered out as markers for distinguishing GLJ before and after alchemy, including B, Si, Mg, K, Cr, and Ni.The contents of Mg, K, Cr and Ni were increased while the contents of B and Si were decreased after alchemy.The difference of the contents after alchemy changed the cold and hot properties of the compound, showing the decrease of dryness, and the hot property was changed to warm and neutral properties; in addition, the membrane permeability and absorption of the compound compositions were improved. In this study, we preliminarily investigated the changes of chemical compositions in GLJ before and after alchemy as well as the effects of alchemy on physical and chemical properties and cold-heat nature of GLJ, laying a foundation for further clarifying the scientific connotation of alchemy process.

Authors+Show Affiliations

Modern Research Center for Traditional Chinese Medicine, Shanxi University Taiyuan 030006, China Department of Traditional Chinese Pharmacy, Shanxi University of Traditional Chinese Medicine Jinzhong 030619, China.Modern Research Center for Traditional Chinese Medicine, Shanxi University Taiyuan 030006, China.Shanxi Guangyuyuan Chinese Medicine Co., Ltd. Jinzhong 030800, China.Shanxi Guangyuyuan Chinese Medicine Co., Ltd. Jinzhong 030800, China.Modern Research Center for Traditional Chinese Medicine, Shanxi University Taiyuan 030006, China.Modern Research Center for Traditional Chinese Medicine, Shanxi University Taiyuan 030006, China Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050, China.

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

32627462

Citation

Shi, Jing-Chao, et al. "[Study On Difference of Chemical Compositions of Guilingji Before and After Alchemy Based On Mass Spectrometry and Multivariate Statistical Analysis]." Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, vol. 45, no. 12, 2020, pp. 2872-2880.
Shi JC, Gao XX, Zhang AR, et al. [Study on difference of chemical compositions of Guilingji before and after alchemy based on mass spectrometry and multivariate statistical analysis]. Zhongguo Zhong Yao Za Zhi. 2020;45(12):2872-2880.
Shi, J. C., Gao, X. X., Zhang, A. R., Zhang, B., Qin, X. M., & DU, G. H. (2020). [Study on difference of chemical compositions of Guilingji before and after alchemy based on mass spectrometry and multivariate statistical analysis]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, 45(12), 2872-2880. https://doi.org/10.19540/j.cnki.cjcmm.20200328.311
Shi JC, et al. [Study On Difference of Chemical Compositions of Guilingji Before and After Alchemy Based On Mass Spectrometry and Multivariate Statistical Analysis]. Zhongguo Zhong Yao Za Zhi. 2020;45(12):2872-2880. PubMed PMID: 32627462.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Study on difference of chemical compositions of Guilingji before and after alchemy based on mass spectrometry and multivariate statistical analysis]. AU - Shi,Jing-Chao, AU - Gao,Xiao-Xia, AU - Zhang,Ai-Rong, AU - Zhang,Bin, AU - Qin,Xue-Mei, AU - DU,Guan-Hua, PY - 2020/7/7/entrez KW - Guilingji KW - ICP-MS KW - UPLC-Q-Orbitrap MS/MS KW - alchemy KW - multivariate statistical analysis SP - 2872 EP - 2880 JF - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica JO - Zhongguo Zhong Yao Za Zhi VL - 45 IS - 12 N2 - UPLC-Q-Orbitrap MS/MS and ICP-MS coupled with multivariate statistical analysis was employed to explore the differences in chemical compositions of Guilingji(GLJ) before and after alchemy.The changes in organic chemical compositions and inorganic elements were observed and 39 differential organic compositions were found in GLJ after alchemy, 24 compounds of which were identified. The differential compositions of GLJ included violet ketones, chalcones, amides, and fatty acids whose contents were increased after alchemy, as well as flavones, isoflavones, dihydroflavones, flavonoid glycosides, and coumarins whose content were decreased after alchemy. This study showed 6 inorganic elements filtered out as markers for distinguishing GLJ before and after alchemy, including B, Si, Mg, K, Cr, and Ni.The contents of Mg, K, Cr and Ni were increased while the contents of B and Si were decreased after alchemy.The difference of the contents after alchemy changed the cold and hot properties of the compound, showing the decrease of dryness, and the hot property was changed to warm and neutral properties; in addition, the membrane permeability and absorption of the compound compositions were improved. In this study, we preliminarily investigated the changes of chemical compositions in GLJ before and after alchemy as well as the effects of alchemy on physical and chemical properties and cold-heat nature of GLJ, laying a foundation for further clarifying the scientific connotation of alchemy process. SN - 1001-5302 UR - https://www.unboundmedicine.com/medline/citation/32627462/[Study_on_difference_of_chemical_compositions_of_Guilingji_before_and_after_alchemy_based_on_mass_spectrometry_and_multivariate_statistical_analysis] DB - PRIME DP - Unbound Medicine ER -
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