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[Study on mechanisms of anti-Alzheimer's disease action of absorbed components of Gardeniae Fructus based on network pharmacology].
Zhongguo Zhong Yao Za Zhi. 2020 Jun; 45(11):2601-2610.ZZ

Abstract

Gardeniae Fructus has the traditional effects of promoting intelligence and inducing resuscitation, but its mechanism is unclear. In this study, the relationship between Gardeniae Fructus's traditional effect of promoting intelligence and inducing resuscitation and anti-Alzheimer's disease effect was taken as the starting point to investigate the anti-Alzheimer's disease mechanism of the major absorbed components in Gardeniae Fructus by the network pharmacology method. The network pharmacology research model of "absorbed composition-target-pathway-disease" was adopted. In this study, the active components screening and target prediction technology were used to determine the active components and targets of Gardeniae Fructus in treatment of Alzheimer's disease. The enrichment pathway and biological process of Gardeniae Fructus were studied by using the bioinformatics annotation database(DAVID), and the results of molecular docking validation network analysis were used to elaborate the mechanism of Gardeniae Fructus in treatment of Alzheimer's disease. It was found that 35 absorbed components of Gardeniae Fructus not only regulated 48 targets such as cholines-terase(BCHE) and carbonic anhydrase 2(CA2), but also affected 11 biological processes(e.g. transcription factor activity, nuclear receptor activity, steroid hormone receptor activity, amide binding and peptide binding) and 7 metabolic pathways(MAPK signaling pathway, Alzheimer disease and estrogen signaling pathway, etc.). Molecular docking results showed that more than 60% of the active components could be well docked with key targets, and the relevant literature also showed that the active components could inhibit the MAPK1 expression of key targets, indicating a high reliability of results. These results indicated that Gardeniae Fructus may play its anti-Alzheimer's disease action via a "multi-ingredients-multi-targets and multi-pathways" mode, providing a scientific basis for further drug research and development.

Authors+Show Affiliations

Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Traditional Chinese Medicine Nanchang 330004, China.Jiangxi People's Hospital Nanchang 330006, China.Research Center for Differentiation and Development of Traditional Chinese Medicine Basic Theory, Jiangxi University of Traditional Chinese Medicine Nanchang 330004, China.Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Traditional Chinese Medicine Nanchang 330004, China.Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Traditional Chinese Medicine Nanchang 330004, China.

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

32627495

Citation

Zhang, Rui, et al. "[Study On Mechanisms of anti-Alzheimer's Disease Action of Absorbed Components of Gardeniae Fructus Based On Network Pharmacology]." Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, vol. 45, no. 11, 2020, pp. 2601-2610.
Zhang R, Zhang JL, Li BT, et al. [Study on mechanisms of anti-Alzheimer's disease action of absorbed components of Gardeniae Fructus based on network pharmacology]. Zhongguo Zhong Yao Za Zhi. 2020;45(11):2601-2610.
Zhang, R., Zhang, J. L., Li, B. T., Hua, C. L., & Liu, R. Q. (2020). [Study on mechanisms of anti-Alzheimer's disease action of absorbed components of Gardeniae Fructus based on network pharmacology]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, 45(11), 2601-2610. https://doi.org/10.19540/j.cnki.cjcmm.20200204.401
Zhang R, et al. [Study On Mechanisms of anti-Alzheimer's Disease Action of Absorbed Components of Gardeniae Fructus Based On Network Pharmacology]. Zhongguo Zhong Yao Za Zhi. 2020;45(11):2601-2610. PubMed PMID: 32627495.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Study on mechanisms of anti-Alzheimer's disease action of absorbed components of Gardeniae Fructus based on network pharmacology]. AU - Zhang,Rui, AU - Zhang,Ji-Lin, AU - Li,Bing-Tao, AU - Hua,Chang-Lin, AU - Liu,Rui-Qi, PY - 2020/7/7/entrez KW - Alzheimer′s disease KW - Gardeniae Fructus KW - absorbed components KW - biology process KW - molecular docking KW - network pharmacology KW - pathway analysis SP - 2601 EP - 2610 JF - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica JO - Zhongguo Zhong Yao Za Zhi VL - 45 IS - 11 N2 - Gardeniae Fructus has the traditional effects of promoting intelligence and inducing resuscitation, but its mechanism is unclear. In this study, the relationship between Gardeniae Fructus's traditional effect of promoting intelligence and inducing resuscitation and anti-Alzheimer's disease effect was taken as the starting point to investigate the anti-Alzheimer's disease mechanism of the major absorbed components in Gardeniae Fructus by the network pharmacology method. The network pharmacology research model of "absorbed composition-target-pathway-disease" was adopted. In this study, the active components screening and target prediction technology were used to determine the active components and targets of Gardeniae Fructus in treatment of Alzheimer's disease. The enrichment pathway and biological process of Gardeniae Fructus were studied by using the bioinformatics annotation database(DAVID), and the results of molecular docking validation network analysis were used to elaborate the mechanism of Gardeniae Fructus in treatment of Alzheimer's disease. It was found that 35 absorbed components of Gardeniae Fructus not only regulated 48 targets such as cholines-terase(BCHE) and carbonic anhydrase 2(CA2), but also affected 11 biological processes(e.g. transcription factor activity, nuclear receptor activity, steroid hormone receptor activity, amide binding and peptide binding) and 7 metabolic pathways(MAPK signaling pathway, Alzheimer disease and estrogen signaling pathway, etc.). Molecular docking results showed that more than 60% of the active components could be well docked with key targets, and the relevant literature also showed that the active components could inhibit the MAPK1 expression of key targets, indicating a high reliability of results. These results indicated that Gardeniae Fructus may play its anti-Alzheimer's disease action via a "multi-ingredients-multi-targets and multi-pathways" mode, providing a scientific basis for further drug research and development. SN - 1001-5302 UR - https://www.unboundmedicine.com/medline/citation/32627495/[Study_on_mechanisms_of_anti-Alzheimer's_disease_action_of_absorbed_components_of_Gardeniae_Fructus_based_on_network_pharmacology] L2 - https://antibodies.cancer.gov/detail/CPTC-MAPK1-3 DB - PRIME DP - Unbound Medicine ER -
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