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Placental pathology and neonatal outcomes in pre-eclampsia with gestational diabetes mellitus.
J Matern Fetal Neonatal Med. 2020 Jul 06 [Online ahead of print]JM

Abstract

OBJECTIVE

To investigate histopathological placental lesions and adverse neonatal outcomes by Pre-eclampsia (PE) with Gestational Diabetes Mellitus (GDM).

METHODS

This was a retrospective cohort study of pregnancies with PE delivered between 1 January 2012 to 1 January 2014. Pregnant women with PE were recruited, and divided into PE with GDM (PE + GDM) group (n = 278) and PE without GDM (PE - GDM) group (n = 586). We compared the placental pathology and neonatal outcomes between the two groups.

RESULTS

The (PE + GDM) group was significantly associated with high placenta weight (534.8 ± 124.1 vs 519.3 ± 132.3 g, p = .011), the large diameter of the placenta (17.8 ± 2.2 vs 16.2 ± 2.7 cm, p = .016) than (PE - GDM) group. The incidence of chorioamnionitis in (PE + GDM) group was significantly higher than (PE - GDM) group [48.9% (136/278) vs 41.5% (243/586), p = .028], whereas there were no significant differences in umbilical cord length and infarction between the two groups. The (PE + GDM) group had a higher rate of prematurity [44.9% (125/278) vs 39.9% (234/586), p = .042] than (PE - GDM) group, in (PE + GDM) group the incidence of LGA [15.1% (42/278) vs 1.0% (6/586), p = .034], RDS [18.7% (52/278) vs 9.2% (54/586), p = .011] and hyperbilirubinemia [10.7% (30/278) vs 1.0% (6/586), p = .038] were higher than (PE - GDM) group.

CONCLUSIONS

GDM increased the offspring's complication in pregnancy with PE, the potential mechanism might be that GDM increased the placenta inflammation.

Authors+Show Affiliations

Department of Neonatology, Guang Dong Women and Children Hospital, Guangzhou, Guangdong, China.Department of Neonatology, Guang Dong Women and Children Hospital, Guangzhou, Guangdong, China.Department of Neonatology, Guang Dong Women and Children Hospital, Guangzhou, Guangdong, China.Department of Neonatology, Guang Dong Women and Children Hospital, Guangzhou, Guangdong, China.Department of Neonatology, Guang Dong Women and Children Hospital, Guangzhou, Guangdong, China.Department of Pathology, Guang Dong Women and Children Hospital, Guangzhou, Guangdong, China.Department of Neonatology, Guang Dong Women and Children Hospital, Guangzhou, Guangdong, China.Department of Neonatology, Guang Dong Women and Children Hospital, Guangzhou, Guangdong, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32627623

Citation

Xu, Fang, et al. "Placental Pathology and Neonatal Outcomes in Pre-eclampsia With Gestational Diabetes Mellitus." The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2020, pp. 1-6.
Xu F, Yang S, Liu Y, et al. Placental pathology and neonatal outcomes in pre-eclampsia with gestational diabetes mellitus. J Matern Fetal Neonatal Med. 2020.
Xu, F., Yang, S., Liu, Y., Zheng, X., Yang, H., Zhang, J., Ren, Z., & Yang, J. (2020). Placental pathology and neonatal outcomes in pre-eclampsia with gestational diabetes mellitus. The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 1-6. https://doi.org/10.1080/14767058.2020.1786513
Xu F, et al. Placental Pathology and Neonatal Outcomes in Pre-eclampsia With Gestational Diabetes Mellitus. J Matern Fetal Neonatal Med. 2020 Jul 6;1-6. PubMed PMID: 32627623.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Placental pathology and neonatal outcomes in pre-eclampsia with gestational diabetes mellitus. AU - Xu,Fang, AU - Yang,Shumei, AU - Liu,Ying, AU - Zheng,Xuaner, AU - Yang,Haoming, AU - Zhang,Jiangyu, AU - Ren,Zhuxiao, AU - Yang,Jie, Y1 - 2020/07/06/ PY - 2020/7/7/entrez KW - Gestational diabetes mellitus KW - neonatal outcomes KW - placental pathology KW - pre-eclampsia SP - 1 EP - 6 JF - The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians JO - J. Matern. Fetal. Neonatal. Med. N2 - OBJECTIVE: To investigate histopathological placental lesions and adverse neonatal outcomes by Pre-eclampsia (PE) with Gestational Diabetes Mellitus (GDM). METHODS: This was a retrospective cohort study of pregnancies with PE delivered between 1 January 2012 to 1 January 2014. Pregnant women with PE were recruited, and divided into PE with GDM (PE + GDM) group (n = 278) and PE without GDM (PE - GDM) group (n = 586). We compared the placental pathology and neonatal outcomes between the two groups. RESULTS: The (PE + GDM) group was significantly associated with high placenta weight (534.8 ± 124.1 vs 519.3 ± 132.3 g, p = .011), the large diameter of the placenta (17.8 ± 2.2 vs 16.2 ± 2.7 cm, p = .016) than (PE - GDM) group. The incidence of chorioamnionitis in (PE + GDM) group was significantly higher than (PE - GDM) group [48.9% (136/278) vs 41.5% (243/586), p = .028], whereas there were no significant differences in umbilical cord length and infarction between the two groups. The (PE + GDM) group had a higher rate of prematurity [44.9% (125/278) vs 39.9% (234/586), p = .042] than (PE - GDM) group, in (PE + GDM) group the incidence of LGA [15.1% (42/278) vs 1.0% (6/586), p = .034], RDS [18.7% (52/278) vs 9.2% (54/586), p = .011] and hyperbilirubinemia [10.7% (30/278) vs 1.0% (6/586), p = .038] were higher than (PE - GDM) group. CONCLUSIONS: GDM increased the offspring's complication in pregnancy with PE, the potential mechanism might be that GDM increased the placenta inflammation. SN - 1476-4954 UR - https://www.unboundmedicine.com/medline/citation/32627623/Placental_pathology_and_neonatal_outcomes_in_pre-eclampsia_with_gestational_diabetes_mellitus L2 - http://www.tandfonline.com/doi/full/10.1080/14767058.2020.1786513 DB - PRIME DP - Unbound Medicine ER -
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